Yvette A. Hayman
Hull York Medical School
PathophysiologyQuality of lifeAirwayInternal medicineDownregulation and upregulationSurgeryPathologyPhagocytosisIntensive care medicineChemistryPhysical therapyProspective cohort studyIngestionEmergency medicinePredictive value of testsImmunologyTHP1 cell lineObservational studyLipid dropletFEV1/FVC ratioRespiratory diseaseLung cancerSomatostatinSputumCOPDContinuous monitoringCystic fibrosisExacerbationChronic coughConvalescenceBronchoalveolar lavageAlveolar macrophageCD80CD14MacrophageCD11cClinical PracticeCorrelation coefficientSpirometryOctreotideTelehealthPopulationDomestic environmentCough FrequencySymptom ratingsCopd exacerbationIdentification systemLiving roomPulmonary diseaseSeverity of illnessHospital dischargeSignificant differenceIn patientEarly dischargePost dischargeTeaching hospitalAfter dischargePatient complianceObjective measurementRefluxRespiratory systemFlow cytometryMedicineCohortCell cultureImmune systemGastroenterologySubjective reportCell biology
11Publications
3H-index
33Citations
Publications 11
Newest
#1Laura R. Sadofsky (Hull York Medical School)H-Index: 12
#2Yvette A. Hayman (Hull York Medical School)H-Index: 3
Last. Alyn H. Morice (Hull York Medical School)H-Index: 2
view all 9 authors...
Purpose There is currently no true macrophage cell line and in vitro experiments requiring these cells currently require mitogenic stimulation of a macrophage precursor cell line (THP-1) or ex vivo maturation of circulating primary monocytes. In this study, we characterise a human macrophage cell line, derived from THP-1 cells, and compare its phenotype to the THP-1 cells.
1 CitationsSource
#1Laura R. Sadofsky (Hull York Medical School)H-Index: 12
#2Yvette A. Hayman (Hull York Medical School)H-Index: 3
Last. Alyn H. Morice (Hull York Medical School)H-Index: 2
view all 4 authors...
1 CitationsSource
#1Michael G. Crooks (Hull York Medical School)H-Index: 12
#2Albertus C. den Brinker (Philips)H-Index: 12
Last. Alyn H. Morice (Hull York Medical School)H-Index: 35
view all 8 authors...
Purpose Cough is common in chronic obstructive pulmonary disease (COPD) and is associated with frequent exacerbations and increased mortality. Cough increases during acute exacerbations (AE-COPD), representing a possible metric of clinical deterioration. Conventional cough monitors accurately report cough counts over short time periods. We describe a novel monitoring system which we used to record cough continuously for up to 45 days during AE-COPD convalescence.
17 CitationsSource
#1Yvette A. Hayman (Hull York Medical School)H-Index: 3
#2Laura R. Sadofsky (Hull York Medical School)H-Index: 12
Last. Alyn H. Morice (Hull York Medical School)H-Index: 35
view all 5 authors...
Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid laden macrophages (LLM) within the airway may indicate aspiration secondary to GOR. The proposed mechanism, that lipid droplets from undigested or partially digested food are aspirated leading to accumulation in scavenging macrophages led us to hypothesise that an activated population of LLM could interact with other immune cells to induce bronchial inf...
6 CitationsSource
#1Michael G. Crooks (Hull York Medical School)H-Index: 12
#2Yvette A. Hayman (Hull York Medical School)H-Index: 3
Last. Alyn H. Morice (Hull York Medical School)H-Index: 29
view all 6 authors...
Abstract Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Cough and sputum production are associated with adverse outcomes in COPD and are common during COPD exacerbation (AE-COPD). This study of objective cough monitoring using the Hull Automated Cough Counter and Leicester Cough Monitor software confirms that this system has the ability to detect a significant decrease in cough frequency during AE-COPD convalescence. The ability to detect clin...
14 CitationsSource
#1Helen Elizabeth Fowles (Hull York Medical School)H-Index: 2
#2Alyn H. Morice (Hull York Medical School)H-Index: 35
Last. Kayleigh Arnell (Castle Hill Hospital)
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Introduction: Octreotide; a synthetic analogue of Somatostatin; has been used successfully in palliative patients with excess gastrointestinal secretions. A number of respiratory patients experience cough with excess sputum production. We postulated that octreotide may reduce sputum volume and therefore improve symptoms. Method 8 Patients were initiated on 50mcg octreotide injections. Patients were assessed monthly for efficacy including symptom scores and spirometry. Patients were fitted with a...
Source
#1Albertus C. den Brinker (Philips)H-Index: 12
#2Peter Douglas Hill (Philips)H-Index: 2
Last. Alyn H. Morice (Hull York Medical School)H-Index: 35
view all 5 authors...
Introduction: Cough is a symptom of respiratory diseases and continuous monitoring of cough may yield a useful marker for disease management, e.g. for verification of recovery after early discharge or early identification of an acute exacerbation of COPD (AECOPD). For chronic coughers, the trends (relative changes) in the objective cough count are considered to be the information carriers. Methods: Cough sound recording and analysis using two remote stationary sensors and a dedicated semi-automa...
Source
#1Yvette A. Hayman (Hull York Medical School)H-Index: 3
#2Laura R. Sadofsky (Hull York Medical School)H-Index: 12
Last. Alyn H. Morice (Hull York Medical School)H-Index: 35
view all 5 authors...
Aims Demonstration of lipid-laden macrophages in respiratory secretions has been suggested to be a marker of reflux and aspiration. However studies looking at the diagnostic value of quantifying macrophage ingested lipids have been inconclusive. We wanted to look evaluate the utility of this technique in diagnosing airway reflux. Methods In this prospective study bronchoalveolar lavage samples were collected from patient’s undergoing flexible bronchoscopy for various indications (lung cancer, ch...
Source
#1Michael G. Crooks (Hull York Medical School)H-Index: 12
#2Yvette A. Hayman (Hull York Medical School)H-Index: 3
Last. Alyn H. Morice (Hull York Medical School)H-Index: 35
view all 5 authors...
Introduction Cough is a symptom of respiratory diseases and continuous monitoring of cough may be a means for disease management, e.g. for early identification of an acute exacerbation of COPD (AECOPD). For continuous monitoring, unobtrusive cough sensors are to be preferred over the commonly used clip-on microphones. However, this means that such a cough sensing and identification system operates in a much more demanding acoustic environment. Methods Unobtrusive cough sound recording and analys...
#1Albertus C. den Brinker (Philips)H-Index: 12
#2Pete Hill (Philips)
Last. Alyn H. Morice (Hull York Medical School)H-Index: 35
view all 5 authors...
Introduction An observational pilot study explores the intrapatient correlations between cough count and subjective symptoms in order to see whether continuous objective cough monitoring yields additional information useable for COPD management. Method Free-field microphones monitored the ambient sound in the living room and the bedroom of COPD patient's homes for a 45 day period. The sound data were analysed by a semi-automated cough classifier. Symptom data were collected on a daily basis usin...