Leonid N. Maslov
Research Medical Center
Internal medicineEndocrinologyCardiologyReceptorChemistryStimulationAntagonistAgonistIschemic preconditioningOpioid receptorReperfusion injuryOpioidContractilityAnesthesiaMyocardial infarctionIschemiaMedicineBiologyOpioid peptidePharmacology
Publications 372
#1E S Prokudina (RAS: Russian Academy of Sciences)H-Index: 5
#2Leonid N. Maslov (RAS: Russian Academy of Sciences)H-Index: 18
Last. Nikita S. Voronkov (RAS: Russian Academy of Sciences)H-Index: 3
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#1Leonid N. Maslov (Research Medical Center)H-Index: 18
#2A. V. Mukhomedzyanov (Research Medical Center)H-Index: 2
Last. Peter R. Oeltgen (UK: University of Kentucky)H-Index: 21
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Abstract null null Coronary artery occlusion (45 min) and reperfusion (2 h) was performed in rats anesthetized with α-chloralose. Opioid receptor agonists were administered intravenously 5 minutes before reperfusion, while opioid receptor antagonists were administered 10 minutes before reperfusion. The non-selective opioid δ-receptor agonist DADLE at a dose of 0.088 mg/kg had no effect the infarct size/area at risk ratio. The selective opioid δ-receptor agonist BW373 was administered at a dose o...
Last. Yue GuanH-Index: 10
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#1Chaoyang Liu (Fourth Military Medical University)H-Index: 1
#2Yuehu Han (Fourth Military Medical University)H-Index: 1
Last. Guoen Wang (Xi'an Jiaotong University)H-Index: 1
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Diabetes disrupts mitochondrial function and often results in diabetic cardiomyopathy (DCM). Paeonol is a bioactive compound that has been reported to have pharmacological potential for cardiac and mitochondrial protection. This study aims to explore the effects of paeonol on mitochondrial disorderes in DCM and the underlying mechanisms. We showed that paeonol promoted Opa1-mediated mitochondrial fusion, inhibited mitochondrial oxidative stress, and preserved mitochondrial respiratory capacity a...
#1Sergey V. Popov (Research Medical Center)H-Index: 13
#2E S Prokudina (Research Medical Center)H-Index: 5
Last. Leonid N. Maslov (Research Medical Center)H-Index: 18
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Despite the recent progress in research and therapy, cardiovascular diseases are still the most common cause of death worldwide, thus new approaches are still needed. The aim of this review is to highlight the cardioprotective potential of urocortins and corticotropin-releasing hormone (CRH) and their signaling. It has been documented that urocortins and CRH reduce ischemic and reperfusion (I/R) injury, prevent reperfusion ventricular tachycardia and fibrillation, and improve cardiac contractili...
While ischemia itself can kill heart muscle, much of the infarction after a transient period of coronary artery occlusion has been found to result from injury during reperfusion. Here we review the role of inflammation and possible pyroptosis in myocardial reperfusion injury. Current evidence suggests pyroptosis's contribution to infarction may be considerable. Pyroptosis occurs when inflammasomes activate caspases that in turn cleave off an N-terminal fragment of gasdermin D. This active fragme...
#1Boris K. Kurbatov (RAS: Russian Academy of Sciences)H-Index: 1
#2E S Prokudina (RAS: Russian Academy of Sciences)H-Index: 5
Last. Andrey S. Sementsov (RAS: Russian Academy of Sciences)
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Takotsubo syndrome (TS) is a rare but dangerous disease that can be fatal. The pathogenesis of TS is not well understood because there is no animal model of TS that fully mimics TS. It has now been documented that stress exposure (24 h) of rats induced the state which is similar TS in human: contracture damage of myofibrils, elevation of the serum creatine kinase MB level, increased 99mTc-pyrophosphate (99mTc-PYP) accumulation in the heart, QTc interval prolongation, and contractility dysfunctio...
#1Sergey V. Popov (RAS: Russian Academy of Sciences)H-Index: 13
Last. Leonid N. MaslovH-Index: 18
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The role of opioid kappa1 and kappa2 receptors in reperfusion cardiac injury was studied. Male Wistar rats were subjected to a 45-min coronary artery occlusion followed by a 120-min reperfusion. Opioid kappa receptor agonists were administered intravenously 5 min before the onset of reperfusion, while opioid receptor antagonists were given 10 min before reperfusion. The average value of the infarct size/area at risk (IS/AAR) ratio was 43 - 48% in untreated rats. Administration of the opioid kapp...
#1Igor KhaliulinH-Index: 15
#2Raimondo AscioneH-Index: 44
Last. M.Saadeh SuleimanH-Index: 18
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The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). 8-Br (10 μM) was administered to Langendorff-perfused rat hearts for 5 min either before or at th...
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