Nicolas Gaspard
Yale University
Internal medicineEtiologyPsychologyCardiologyNeurologyRetrospective cohort studyNeuroscienceIctalIntensive care medicinePediatricsProspective cohort studyStatus epilepticusEpilepsyIn patientAnesthesiaRefractoryElectroencephalographyAudiologyMedicineBiology
Publications 142
#1Lorenzo Ferlini (Free University of Brussels)
#2Fuhong Su (Free University of Brussels)H-Index: 20
Last. Nicolas Gaspard (Free University of Brussels)H-Index: 29
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The increase in neuronal activity induced by a single seizure is supported by a rise in the cerebral blood flow and tissue oxygenation, a mechanism called neurovascular coupling (NVC). Whether cerebral and systemic hemodynamics are able to match neuronal activity during recurring seizures is unclear, as data from rodent models are at odds with human studies. In order to clarify this issue, we used an invasive brain and systemic monitoring to study the effects of chemically induced non-convulsive...
#1Ilaria Alice Crippa (ULB: Université libre de Bruxelles)H-Index: 11
#2Jean Louis Vincent (ULB: Université libre de Bruxelles)H-Index: 187
Last. Fabio Silvio Taccone (ULB: Université libre de Bruxelles)H-Index: 72
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Background null Little is known about the prevalence of altered CAR in anoxic brain injury and the association with patients' outcome. We aimed at investigating CAR in cardiac arrest survivors treated by targeted temperature management and its association to outcome. null Methods null Retrospective analysis of prospectively collected data. null Inclusion criteria null adult cardiac arrest survivors treated by targeted temperature management (TTM). null Exclusion criteria null trauma; sepsis, int...
#1Wei-Long Zheng (Harvard University)H-Index: 21
#2Edilberto Amorim (UCSF: University of California, San Francisco)H-Index: 9
Last. Trudy Pang (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 10
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Abstract null null Objective null Electroencephalography (EEG) is an important tool for neurological outcome prediction after cardiac arrest. However, the complexity of continuous EEG data limits timely and accurate interpretation by clinicians. We develop a deep neural network (DNN) model to leverage complex EEG trends for early and accurate assessment of cardiac arrest coma recovery likelihood. null null null Methods null We developed a multiscale DNN combining convolutional neural networks (C...
#1Charlotte Damien (ULB: Université libre de Bruxelles)H-Index: 1
Last. Nicolas Gaspard (Yale University)H-Index: 29
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Abstract null null Introduction null Non-convulsive seizures (NCSz) and non-convulsive status epilepticus (NCSE) are frequent in critically ill patients. Specific temporal thresholds to define both are lacking and may be needed to guide appropriate treatment. null null null Method null Retrospective review of 995 NCSz captured during continuous EEG monitoring of 111 consecutive critically ill patients. Seizures were classified according to their type and underlying etiology (acute or progressive...
#6Andrea Minini (ULB: Université libre de Bruxelles)H-Index: 4
#9S. Schuind (ULB: Université libre de Bruxelles)H-Index: 2
#1Lorenzo PelusoH-Index: 7
Last. Jacques CreteurH-Index: 35
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Introduction: The aims of this study were to assess the concordance of different tools and to describe the accuracy of a multimodal approach to predict unfavorable neurological outcome (UO) in cardiac arrest patients. Methods: Retrospective study of adult (>18 years) cardiac arrest patients who underwent multimodal monitoring; UO was defined as cerebral performance category 3–5 at 3 months. Predictors of UO were neurological pupillary index (NPi) ≤ 2 at 24 h; highly malignant patterns on EEG (HM...
#1Claudine Sculier (Boston Children's Hospital)H-Index: 3
#2Cristina Barcia Aguilar (Boston Children's Hospital)H-Index: 2
Last. James Nicholas Brenton (University of Virginia Health System)H-Index: 5
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OBJECTIVE We aimed to characterize the clinical profile and outcomes of new onset refractory status epilepticus (NORSE) in children, and investigated the relationship between fever onset and status epilepticus (SE). METHODS Patients with refractory SE (RSE) between June 1, 2011 and October 1, 2016 were prospectively enrolled in the pSERG (Pediatric Status Epilepticus Research Group) cohort. Cases meeting the definition of NORSE were classified as "NORSE of known etiology" or "NORSE of unknown et...
Abstract Objective Reactivity assessment during EEG might provide important prognostic information in post-anoxic coma. It is still unclear how best to perform reactivity testing and how it might be affected by hypothermia. Our primary aim was to determine and compare the effectiveness, inter-rater reliability and prognostic value of different types of stimulus for EEG reactivity testing, using a standardized stimulation protocol and standardized definitions. Our secondary aims were to assess th...
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