Toshifumi Ozaki
Okayama University
AnatomyInternal medicineRadiologySoft tissueSurgeryPathologyMagnetic resonance imagingChemistryOsteoarthritisChemotherapyOsteosarcomaSarcomaMedial meniscusPosterior rootOrthodonticsRadiographyCancer researchOrthopedic surgeryMedicineBiology
746Publications
57H-index
7,224Citations
Publications 737
Newest
#1Rongsheng Huang (Okayama University)
#2Atsushi Fujimura (Okayama University)H-Index: 13
Last. Atsunori Kamiya (Okayama University)H-Index: 21
view all 9 authors...
Abstract Malignant peripheral nerve sheath tumor (MPNST), a highly malignant tumor that arises in peripheral nerve tissues, is known to be highly resistant to radiation and chemotherapy. Although there are several reports on genetic mutations and epigenetic changes that define the pathogenesis of MPNST, there is insufficient information regarding the microenvironment that contributes to the malignancy of MPNST. In the present study, we demonstrate that adrenaline increases the cancer stem cell p...
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#1Tomohiro Fujiwara (Okayama University)H-Index: 16
#2Mohamed A. Yakoub (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
Last. John H. Healey (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 96
view all 17 authors...
Colony-stimulating factor 1 (CSF-1) is a primary regulator of the survival, proliferation, and differentiation of monocyte/macrophage that sustains the pro-tumorigenic functions of tumor-associated macrophages (TAMs). Considering current advances in understanding the role of the inflammatory tumor microenvironment, targeting the components of the sarcoma microenvironment, such as TAMs, is a viable strategy. Here, we investigated the effect of PLX3397 (pexidartinib) as a potent inhibitor of the C...
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PURPOSE Postoperative radiographs are routinely used to assess fracture reduction following intramedullary nail fixation for pertrochanteric fractures, even though computed tomography (CT) is a superior modality. We aimed to determine the association between reduction quality assessed by CT and rates of reoperation and to evaluate the association of reoperation and reduction quality according to the assessment modality (plain radiographs vs. CT). METHODS A retrospective analysis of 299 consecuti...
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#1Takaaki Hiranaka (Okayama University)H-Index: 9
#2Takayuki Furumatsu (Okayama University)H-Index: 31
Last. Toshifumi Ozaki (Okayama University)H-Index: 57
view all 6 authors...
BACKGROUND During transtibial pullout repair of medial meniscus (MM) posterior root tears (MMPRTs), accurate tibial tunnel creation within the anatomic MM posterior root attachment seems critical. This study aimed to evaluate the tibial tunnel position created by a newly-developed Precision guide during pullout repair of MMPRTs. METHODS In 40 patients who underwent transtibial pullout repairs, the tibial tunnel was created using the Unicorn Meniscal Root (UMR) (n = 20) or Precision guide (n = 20...
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#1Ximing Zhang (Okayama University)H-Index: 4
#2Takayuki Furumatsu (Okayama University)H-Index: 31
Last. Toshifumi Ozaki (Okayama University)H-Index: 57
view all 8 authors...
Purpose/Aim of the study: Previous studies have noted distinctions between medial meniscus posterior root and horn cells. However, the characteristics of root remnant cells have not been explored in detail. The purpose of this study was to evaluate the gene expression levels, proliferation, and resistance to mechanical stress of remnant and horn cells. Materials and Methods: Medial meniscus tissue samples were obtained from patients who underwent total or uni-compartmental knee arthroplasty. Cel...
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#2Eiji NakataH-Index: 7
Last. Toshifumi OzakiH-Index: 57
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Psychological distress is common in patients with soft tissue and bone tumors. We first investigated its frequency and the associated risk factors in patients with pre-operative bone and soft tissue tumors. Participants included 298 patients with bone and soft tissue tumors who underwent surgery in our institution between 2015 and 2020. Psychological distress was evaluated by the Distress and Impact Thermometer (DIT) that consists of two types of questions (questions about the severity of the pa...
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#1Yoshiaki Oda (Okayama University)H-Index: 2
#2Takamitsu TokiokaH-Index: 2
Last. Toshifumi Ozaki (Okayama University)H-Index: 57
view all 3 authors...
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#1Shunji Okita (Okayama University)
#2Hajime IshikawaH-Index: 12
Last. Toshifumi Ozaki (Okayama University)H-Index: 57
view all 8 authors...
OBJECTIVES This retrospective study aimed to investigate the risk factors associated with delayed wound healing (DWH) after orthopedic surgery in rheumatoid arthritis (RA) patients treated with biological disease-modifying antirheumatic drugs (bDMARDs). METHODS We reviewed medical records of 276 orthopedic procedures for 187 RA patients treated with bDMARDs. As a preoperative nutritional status assessment, we evaluated body mass index (BMI), prognostic nutritional index (PNI), and controlling nu...
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#1Yusuke Mochizuki (Okayama University)H-Index: 2
#2Hiroshi Tazawa (Okayama University)H-Index: 29
Last. Toshiyoshi Fujiwara (Okayama University)H-Index: 63
view all 14 authors...
Immune checkpoint inhibitors including anti-programmed cell death 1 (PD-1) antibody have recently improved clinical outcome in certain cancer patients; however, osteosarcoma (OS) patients are refractory to PD-1 blockade. Oncolytic virotherapy has emerged as novel immunogenic therapy to augment antitumor immune response. We developed a telomerase-specific replication-competent oncolytic adenovirus OBP-502 that induces lytic cell death via binding to integrins. In this study, we assessed the combi...
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#1Ximing Zhang (Okayama University)H-Index: 4
#2Takayuki Furumatsu (Okayama University)H-Index: 31
Last. Toshifumi Ozaki (Okayama University)H-Index: 57
view all 8 authors...
Abstract Background Severe chondral lesions and varus knee alignment are associated with poor outcomes following transtibial pullout repair for medial meniscus posterior root tears and meniscus tear is strongly associated with body mass index. The prognostic factors in well-aligned knees (femorotibial angle Methods We retrospectively reviewed the files of 28 patients who had undergone pullout repair of medial meniscus posterior root tears between October 2016 and December 2017. We recorded the b...
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