Thomas Werge
Lundbeck
GeneGenome-wide association studyPsychiatryInternal medicineGenotypeSNPSingle-nucleotide polymorphismPsychologyAlleleGenetic associationAutismBipolar disorderAutism spectrum disorderPsychosisPopulationGeneticsClinical psychologyMedicineSchizophreniaBiology
469Publications
77H-index
33kCitations
Publications 444
Newest
#1Freja Herborg (UCPH: University of Copenhagen)H-Index: 4
#2Kathrine L. Jensen (UCPH: University of Copenhagen)H-Index: 4
Last. Mattias Rickhag (UCPH: University of Copenhagen)H-Index: 9
view all 23 authors...
Dysfunctional dopaminergic neurotransmission is central to movement disorders and mental diseases. The dopamine transporter (DAT) regulates extracellular dopamine levels but the genetic and mechanistic link between DAT function and dopamine-related pathologies is not clear. Particularly, the pathophysiological significance of monoallelic missense mutations in DAT is unknown. Here we use clinical information, neuroimaging, and large-scale exome sequencing data to uncover the occurrence and phenot...
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#1Veera M. Rajagopal (Lundbeck)H-Index: 10
#2Jinjie Duan (Lundbeck)
Last. Marie Bækvad-Hansen (AU: Aarhus University)H-Index: 13
view all 22 authors...
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder, with onset in childhood ("childhood ADHD"), and around two thirds of affected individuals will continue to have ADHD symptoms in adulthood ("persistent ADHD"). Age at first diagnosis can vary, and sometimes ADHD is first diagnosed in adulthood ("late-diagnosed ADHD"). null In this study, we analyzed a large Danish population-based case-cohort generated by iPSYCH in order to identify common genetic risk loci and per...
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#1Maria Didriksen (Copenhagen University Hospital)H-Index: 5
#2Thomas Werge (Lundbeck)H-Index: 77
Last. Christian Erikstrup (Aarhus University Hospital)H-Index: 32
view all 15 authors...
The everyday lives of Danish inhabitants have been affected by the COVID-19 pandemic, e.g., by social distancing, which was employed by the government in March 2020 to prevent the spread of SARS-CoV-2. Moreover, the pandemic has entailed economic consequences for many people. This study aims to assess changes in physical and mental health-related quality of life (MCS, PCS), in stress levels, and quality of sleep during the COVID-19 pandemic and to identify factors that impact such changes, using...
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#1Sonja LaBianca (Lundbeck)H-Index: 1
Last. Vivek Appadurai (Lundbeck)H-Index: 11
view all 27 authors...
Attention deficit hyperactivity disorder (ADHD) is a complex disorder with heterogeneous clinical presentations that manifest variability in long-term outcomes. The genetic contributions to this clinical heterogeneity, however, are not well understood. Here, we study 14 084 individuals diagnosed with ADHD to identify several genetic factors underlying clinical heterogeneity. One genome-wide significant locus was specifically associated with an autism spectrum disorder (ASD) diagnosis among indiv...
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#1Clara Albiñana (Lundbeck)H-Index: 2
#2Jakob GroveH-Index: 51
Last. Bjarni J. Vilhjálmsson (Lundbeck)H-Index: 25
view all 13 authors...
Summary The accuracy of polygenic risk scores (PRSs) to predict complex diseases increases with the training sample size. PRSs are generally derived based on summary statistics from large meta-analyses of multiple genome-wide association studies (GWASs). However, it is now common for researchers to have access to large individual-level data as well, such as the UK Biobank data. To the best of our knowledge, it has not yet been explored how best to combine both types of data (summary statistics a...
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#1Ron Nudel (CMHS: Mental Health Services)H-Index: 3
#1Ron Nudel (Lundbeck)H-Index: 9
Last. Michael E. Benros (Lundbeck)H-Index: 32
view all 6 authors...
BACKGROUND Infections are a major disease burden worldwide. While they are caused by external pathogens, host genetics also plays a part in susceptibility to infections. Past studies have reported diverse associations between human leukocyte antigen (HLA) alleles and infections, but many were limited by small sample sizes and/or focused on only one infection. METHODS We performed an immunogenetic association study examining 13 categories of severe infection (bacterial, viral, central nervous sys...
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#1Xueping Liu (Centre for Mental Health)H-Index: 6
#1Xueping Liu (Centre for Mental Health)H-Index: 1
Last. Michael E. Benros (Centre for Mental Health)H-Index: 32
view all 15 authors...
1 CitationsSource
#1Strom Ni (Humboldt University of Berlin)
#2Jakob Grove (AU: Aarhus University)H-Index: 51
Last. Mattheisen M (Dal: Dalhousie University)H-Index: 1
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Among patients with obsessive-compulsive disorder (OCD), 65-85% manifest another psychiatric disorder concomitantly or at some other time point during their life. OCD is highly heritable, as are many of its comorbidities. A possible genetic heterogeneity of OCD in relation to its comorbid conditions, however, has not yet been exhaustively explored. We used a framework of different approaches to study the genetic relationship of OCD with three commonly observed comorbidities, namely major depress...
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#1Manuel Mattheisen (Dal: Dalhousie University)
#1Mattheisen M (Dal: Dalhousie University)H-Index: 1
Last. Anders D. Børglum (AU: Aarhus University)H-Index: 67
view all 33 authors...
Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable neurodevelopmental disorders with a considerable overlap in their genetic etiology. We dissected their shared and distinct genetic architecture by cross-disorder analyses of large data sets, including samples with information on comorbid diagnoses. We identified seven loci shared by the disorders and the first five genome-wide significant loci differentiating the disorders. All five differenti...
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#1Carin A. T. C. Lunenburg (Aarhus University Hospital)
#1Carin A.T.C. Lunenburg (AU: Aarhus University)H-Index: 2
Last. Christiane Gasse (Aarhus University Hospital)H-Index: 28
view all 11 authors...
Pharmacogenetics aims to improve clinical care by studying the relationship between genetic variation and variable drug response. Large population-based datasets could improve our current understanding of pharmacogenetics from selected study populations. We provide real-world pharmacogenetic frequencies of genotypes and (combined) phenotypes of a large Danish population-based case-cohort sample (iPSYCH2012; data of the Integrative Psychiatric Research consortium). The genotyped sample consists o...
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