Amelia Evoli
Catholic University of the Sacred Heart
Internal medicineEndocrinologySurgeryPathologyAntibodyAutoantibodyPediatricsImmunologyOcular myastheniaMyasthenia gravisPrednisoneAutoimmune diseaseDiseaseThymomaThymectomyWeaknessNeuromuscular transmissionMedicineAcetylcholine receptorGastroenterology
211Publications
54H-index
6,613Citations
Publications 212
Newest
#1Valentina Damato (Agostino Gemelli University Polyclinic)H-Index: 14
#2Claudia Papi (UCSC: Catholic University of the Sacred Heart)H-Index: 2
Last. Raffaele Iorio (Agostino Gemelli University Polyclinic)H-Index: 30
view all 16 authors...
BACKGROUND AND PURPOSE This study was undertaken to assess the long-term outcome of patients with paraneoplastic and non paraneoplastic autoimmune cerebellar ataxia (ACA) using the Scale for the Assessment and Rating of Ataxia (SARA). METHODS Patients with subacute cerebellar ataxia admitted to our institution between September 2012 and April 2020 were prospectively recruited. Serum and/or cerebrospinal fluid was tested for neural autoantibodies by indirect immunofluorescence on mouse brain, cel...
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#1Amelia Evoli (UCSC: Catholic University of the Sacred Heart)H-Index: 54
#2Nils Erik Gilhus (Haukeland University Hospital)H-Index: 65
Last. Jeffrey T. Guptill (Duke University)H-Index: 21
view all 3 authors...
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OBJECTIVE Patients with myasthenia gravis associated with muscle-specific tyrosine kinase antibodies (MuSK-MG) often manifest signs of cholinergic hyperactivity with standard doses of acetylcholinesterase inhibitors (AChE-Is). Aim of the study was to investigate whether repetitive compound muscle action potential (R-CMAP), the neurophysiological correlate of cholinergic hyperactivity, was present in MuSK-MG irrespective of AChE-I treatment. METHODS Patients with confirmed diagnosis of MuSK-MG we...
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#1Gianvito Masi (UCSC: Catholic University of the Sacred Heart)H-Index: 3
#2Gregorio Spagni (UCSC: Catholic University of the Sacred Heart)H-Index: 7
Last. Raffaele Iorio (UCSC: Catholic University of the Sacred Heart)H-Index: 30
view all 8 authors...
Abstract Tissue-based assay (TBA) is a widely-used method to detect neural autoantibodies, but the diagnostic accuracy for autoimmune encephalitis (AE) has not yet been adequately measured. We retrospectively evaluated the sensitivity and specificity of an indirect immunofluorescence TBA (IIF-TBA) in 159 patients with suspected AE. Serum and cerebrospinal fluid (CSF) specimens were collected and tested from December 2012 to September 2020. In the paired sample analysis, serum testing showed high...
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#1Amelia Evoli (UCSC: Catholic University of the Sacred Heart)H-Index: 54
#2Gregorio Spagni (UCSC: Catholic University of the Sacred Heart)H-Index: 7
Last. Valentina Damato (UCSC: Catholic University of the Sacred Heart)H-Index: 14
view all 4 authors...
INTRODUCTION Myasthenia gravis is a rare disease of the neuromuscular junction and a prototype of B cell driven immunopathology. Pathogenic antibodies target post-synaptic transmembrane proteins, most commonly the nicotinic acetylcholine receptor and the muscle-specific tyrosine kinase, inducing end-plate alterations and neuromuscular transmission impairment. Several clinical subtypes are distinct on the basis of associated antibodies, age at symptom onset, thymus pathology, genetic factors and ...
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#1Andrea AssiniH-Index: 13
#2Ilaria GandogliaH-Index: 8
Last. Massimo Del SetteH-Index: 28
view all 6 authors...
We thank Drs Finsterer and Scorza for their comments on our case report "Myasthenia gravis associated with anti-MuSK antibodies developed after SARS-CoV-2 infection". At least 6 patients with new-onset myasthenia gravis (MG) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been published so far. In these reports, the latency between the first signs of Coronavirus Disease 2019 (COVID-19) and symptoms of MG ranged from 5 to 30 days.
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#1Andrea AssiniH-Index: 13
#2Ilaria GandogliaH-Index: 8
Last. Massimo Del SetteH-Index: 28
view all 6 authors...
Introduction Since the onset of the novel coronavirus pandemic, several neurological complications secondary to SARS-CoV-2 infection have been reported, affecting central nervous system, peripheral nervous system and neuromuscular junction. Case report We present the case of a 77-year-old man who developed bulbar myasthenia gravis (MG) eight weeks after SARS-CoV-2 infection. The search for serum antibodies against the acetylcholine receptor, the muscle-specific tyrosine kinase (MuSK), and the lo...
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#1Amelia Evoli (UCSC: Catholic University of the Sacred Heart)H-Index: 54
#2Raffaele Iorio (UCSC: Catholic University of the Sacred Heart)H-Index: 30
Myasthenia gravis (MG) with symptoms limited to eye muscles [ocular MG (OMG)] is a rare disease. OMG incidence varies according to ethnicity and age of onset. In recent years, both an increase in incidence rate, particularly in the elderly, and a lower risk for secondary generalization may have contributed to the growing disease prevalence in Western countries. OMG should be considered in patients with painless ptosis and extrinsic ophthalmoparesis. Though asymmetric muscle involvement and sympt...
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