Norhafiza M. Arshad
University of Malaya
CancerCellMolecular biologyCytotoxic T cellChemistryApoptosisIn vitroAutophagyImmunohistochemistryIn vivoAlpinia conchigeraCisplatinMTT assayCathepsin BProgrammed cell deathCancer researchMedicineBlotCell biologyCancer cell
10Publications
4H-index
56Citations
Publications 11
Newest
#1Devanthiran Letchumanan (UM: University of Malaya)
#2Sophia P. M. Sok (UM: University of Malaya)H-Index: 3
Last. Norhafiza M. Arshad (UM: University of Malaya)H-Index: 4
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Plants are rich in phytoconstituent biomolecules that served as a good source of medicine. More recently, they have been employed in synthesizing metal/metal oxide nanoparticles (NPs) due to their capping and reducing properties. This green synthesis approach is environmentally friendly and allows the production of the desired NPs in different sizes and shapes by manipulating parameters during the synthesis process. The most commonly used metals and oxides are gold (Au), silver (Ag), and copper ...
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#1Bavani SubramaniamH-Index: 1
Last. Noor Hasima NagoorH-Index: 11
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1′-acetoxychavicol acetate (ACA) extracted from the rhizomes of Alpinia conchigera Griff (Zingiberaceae) has been shown to deregulate the NF-ĸB signaling pathway and induce apoptosis-mediated cell death in many cancer types. However, ACA is a hydrophobic ester, with poor solubility in an aqueous medium, limited bioavailability, and nonspecific targeting in vivo. To address these problems, ACA was encapsulated in a nanostructured lipid carrier (NLC) anchored with plerixafor octahydrochloride (AMD...
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#1Hani Sapili (UM: University of Malaya)H-Index: 1
#2Chai San Ho (UM: University of Malaya)H-Index: 1
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 11
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Geranylated 4-phenylcoumarins DMDP-1 and DMDP-2 isolated from Mesua elegans were elucidated for their role in inducing caspase-independent programmed cell death (CI-PCD) in prostate cancer cell lines, PC-3 and DU 145, respectively. Cell homeostasis disruption was demonstrated upon treatment, as shown by the increase in calcium ion through colourimetric assay and endoplasmic reticulum (ER) stress markers GRP 78 and p-eIF2α through western blot. Subsequently, cytoplasmic death protease calpain-2 a...
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#1Su Ki Liew (UM: University of Malaya)H-Index: 3
#2Sharan Malagobadan (UM: University of Malaya)H-Index: 2
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 11
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There are innumerable anticancer compounds derived from either natural or synthetic origins. Many of these compounds have been further developed through structural modifications to not only inhibit cancer cell growth but also to exert an antimetastatic effect. This is achieved by attaching different substituents to generate different structure–activity relationships. This review highlights the effectiveness of different functional groups known to have antimigration and antiproliferation activiti...
3 CitationsSource
#1Menaga Subramaniam (UM: University of Malaya)H-Index: 2
#2Norhafiza M. Arshad (UM: University of Malaya)H-Index: 4
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 11
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Cancer development and progression are extremely complex due to the alteration of various genes and pathways. In most cases, multiple agents are required to control cancer progression. The purpose of this study is to investigate, using a mouse model, the synergistic interactions of anti-cancer agents, 1′-S-1′-acetoxychavicol acetate (ACA), Mycobacterium indicus pranii (MIP), and cisplatin (CDDP) in double and triple combinations to treat chemo-sensitize and immune-sensitize breast cancer. Change...
1 CitationsSource
#1Nurhisyam ZakariaH-Index: 1
Last. Noor Hasima NagoorH-Index: 11
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Background: Pinnatane A from the bark of Walsura pinnata was investigated for its anti-cancer properties by analyzing the cytotoxic activities and cell cycle arrest mechanism induced in two different liver cancer cell lines. Methods: A 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was used to analyze the pinnatane A selectivity in inducing cell death in cancer and normal cells. Various biological assays were carried out to analyze the anti-cancer properties of pinn...
3 CitationsSource
#1Yasir Osman Ali Abdalla (UM: University of Malaya)H-Index: 1
#2Shaik Nyamathulla (UM: University of Malaya)H-Index: 7
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 11
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Abstract 1′-S-1′-acetoxychavicol acetate (ACA) has been previously reported to reduce tumor volume in nude mice, at an effective dose of 1.56 mg/kg body weight. However, the detailed toxicological profile for ACA has not yet been performed. Herein, we investigated the toxicity of intravenous administration of ACA in male and female Sprague-Dawley rats, both acutely (with single doses of 2.00, 4.00 and 6.66 mg/kg body weight, for 14 days), and sub-acutely (with weekly injections of 0.66, 1.33, an...
8 CitationsSource
#1Sophia P. M. Sok (UM: University of Malaya)H-Index: 3
#2Norhafiza M. Arshad (UM: University of Malaya)H-Index: 4
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 11
view all 6 authors...
Autophagy plays a role in deciding the fate of cells by inducing either survival or death. 1’S-1-acetoxychavicol acetate (ACA) is a phenylpropanoid isolated from rhizomes of Alpinia conchigera and has been reported previously on its apoptotic effects on various cancers. However, the effect of ACA on autophagy remains ambiguous. The aims of this study were to investigate the autophagy-inducing ability of ACA in human non-small cell lung cancer (NSCLC), and to determine its role as pro-survival or...
6 CitationsSource
#1Noor Shahirah Suparji (UM: University of Malaya)H-Index: 1
#2Gomathi Chan (UM: University of Malaya)H-Index: 7
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 11
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Geranylated 4-phenylcoumarins, DMDP-1 & -2 isolated from Mesua elegans were investigated for anticancer potential against human prostate cancer cells. Treatment with DMDP-1 & -2 resulted in cell death in a time and dose dependent manner in an MTT assay on all cancer cell lines tested with the exception of lung adenocarcinoma cells. DMDP-1 showed highest cytotoxic efficacy in PC-3 cells while DMDP-2 was most potent in DU 145 cells. Flow cytometry indicated that both coumarins were successful to i...
15 CitationsSource
#2Lionel L. A. InH-Index: 11
Last. Noor Hasima NagoorH-Index: 11
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// Norhafiza M. Arshad 1 , Lionel L.A. In 2 , Tchen Lin Soh 2 , Mohamad Nurul Azmi 4 , Halijah Ibrahim 3 , Khalijah Awang 4 , Elena Dudich 6 , Eduard Tatulov 6 and Noor Hasima Nagoor 1,5 1 Institute of Biological Science (Genetics and Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia 2 Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia 3 Institute of Biological Science (Ecology and Biodiversity), Faculty of Science...
11 CitationsSource