Prashanth K.B. Nagesh
Memorial Sloan Kettering Cancer Center
Drug resistanceCancerBiophysicsNanotechnologyChemistryApoptosisIn vitroIn vivoChemotherapyPaclitaxelMetastasisDrug deliveryDrugProstate cancerDocetaxelTannic acidCell cycleCancer researchCell growthMedicineCell cultureCancer cell
39Publications
10H-index
433Citations
Publications 36
Newest
#1Jimmy A. Rotolo (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 16
#2Chii Shyang Fong (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
Last. Richard Kolesnick (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 80
view all 11 authors...
After 9/11, threat of nuclear attack on American urban centers prompted government agencies to develop medical radiation countermeasures to mitigate hematopoietic-acute radiation syndrome (H-ARS) and higher-dose gastrointestinal-ARS (GI-ARS) lethality. While re-purposing leukemia drugs that enhance bone marrow repopulation successfully treats H-ARS in pre-clinical models, no mitigator potentially deliverable under mass casualty conditions preserves GI tract. Here we generate anti-ceramide 6B5 si...
1 CitationsSource
#1Elham Hatami (UTHSC: University of Tennessee Health Science Center)H-Index: 6
#2Prashanth K.B. Nagesh (UTHSC: University of Tennessee Health Science Center)H-Index: 10
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
view all 5 authors...
Abstract Non-small cell lung cancer (NSCLC) is the most frequent type of lung cancer accounting up to 80–85% of all lung cancer (LC) cases. Gemcitabine (Gem), a pyrimidine nucleoside antimetabolite, is widely used chemotherapy offering several months survival benefit in patients with NSCLC. The emergence of Gem resistance is a main clinical concern in cancer treatment and thus a continuous demand for development of new therapeutic strategies to improve its antitumor activity. Hence, we report an...
2 CitationsSource
#1Yuqing Gong (UTHSC: University of Tennessee Health Science Center)H-Index: 7
#2Kaining Zhi (UTHSC: University of Tennessee Health Science Center)H-Index: 3
Last. Santosh Kumar (UTHSC: University of Tennessee Health Science Center)H-Index: 96
view all 9 authors...
Even with an efficient combination of antiretroviral therapy (ART), which significantly decreases viral load in human immunodeficiency virus type 1 (HIV-1)-positive individuals, the occurrence of HIV-1-associated neurocognitive disorders (HAND) still exists. Microglia have been shown to have a significant role in HIV-1 replication in the brain and in subsequent HAND pathogenesis. However, due to the limited ability of ART drugs to cross the blood–brain barrier (BBB) after systemic administration...
8 CitationsSource
#1Advait B. Shetty (UTHSC: University of Tennessee Health Science Center)H-Index: 3
#2Prashanth K.B. Nagesh (University of Texas at Austin)H-Index: 10
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 49
view all 7 authors...
Pancreatic cancer (PanCa) is a highly lethal disease with a poor 5 year survival rate, less than 7%. It has a dismal prognosis, and more than 50% of cases are detected at an advanced and metastatic stage. Gemcitabine (GEM) is a gold standard chemotherapy used for PanCa treatment. However, GEM-acquired resistance in cancer cells is considered as a major setback for its continued clinical implementation. This phenomenon is evidently linked to de novo lipid synthesis. PanCa cells rely on de novo li...
2 CitationsSource
#1Yuqing Gong (UTHSC: University of Tennessee Health Science Center)H-Index: 7
#2Pallabita Chowdhury (UTHSC: University of Tennessee Health Science Center)H-Index: 12
Last. Santosh Kumar (UTHSC: University of Tennessee Health Science Center)H-Index: 96
view all 7 authors...
The use of antiretroviral therapy (ART) has remarkably decreased the morbidity associated with HIV-1 infection, however, the prevalence of HIV-1-associated neurocognitive disorders (HAND) is still increasing. The blood-brain barrier (BBB) is the major impediment for penetration of antiretroviral drugs, causing therapeutics to reach only suboptimal level to the brain. Conventional antiretroviral drug regimens are not sufficient to improve the treatment outcomes of HAND. In our recent report, we h...
26 CitationsSource
#1Vivek K. Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 8
#1Vivek Kumar Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 1
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 49
view all 14 authors...
Abstract In this study, we investigated the therapeutic efficacy of VERU-111 in vitro and in vivo model systems of cervical cancer. VERU-111 treatment inhibited cell proliferation and, clonogenic potential, induce accumulation of p53 and down regulated the expression of HPV E6/E7 expression in cervical cancer cells. In addition, VERU-111 treatment also decreased the expression of phosphorylation of Jak2 (TyR1007/1008) and STAT3 at Tyr705 and Ser727. VERU-111 treatment arrested cell cycle in the ...
3 CitationsSource
#1Prashanth K.B. Nagesh (University of Texas at Austin)H-Index: 10
#2Pallabita Chowdhury (UTHSC: University of Tennessee Health Science Center)H-Index: 12
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
view all 9 authors...
Prostate cancer (PCa) cells exploit the aberrant lipid signaling and metabolism as their survival advantage. Also, intracellular storage lipids act as fuel for the PCa proliferation. However, few studies were available that addressed the topic of targeting lipid metabolism in PCa. Here, we assessed the tannic acid (TA) lipid-targeting ability and its capability to induce endoplasmic reticulum (ER) stress by reactive oxygen species (ROS) in PCa cells. TA exhibited dual effects by inhibiting lipog...
9 CitationsSource
#1Prakash Adhikari (MSU: Mississippi State University)H-Index: 4
#2Prashanth K.B. Nagesh (University of Texas at Austin)H-Index: 10
Last. Prabhakar Pradhan (MSU: Mississippi State University)H-Index: 17
view all 7 authors...
A mesoscopic physics-based optical imaging technique, partial wave spectroscopy (PWS), has been used for the detection of cancer by probing nanoscale structural alterations in cells/tissue. The development of drug-resistant cancer cells/tissues during chemotherapy is a major challenge in cancer treatment. In this paper, using a mouse model and PWS, the structural properties of tumor tissue grown in 3D structures by xenografting drug-resistant and drug-sensitive human prostate cancer cells having...
4 CitationsSource
#1Prashanth K.B. Nagesh (University of Texas at Austin)H-Index: 10
#2Pallabita Chowdhury (UTHSC: University of Tennessee Health Science Center)H-Index: 12
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
view all 11 authors...
Cellular senescence is one of the prevailing issues in cancer therapeutics that promotes cancer relapse, chemoresistance, and recurrence. Patients undergoing persistent chemotherapy often develop drug-induced senescence. Docetaxel, an FDA-approved treatment for prostate cancer, is known to induce cellular senescence which often limits the overall survival of patients. Strategic therapies that counter the cellular and drug-induced senescence are an unmet clinical need. Towards this an effort was ...
9 CitationsSource
#1Prakash AdhikariH-Index: 4
Last. Prabhakar PradhanH-Index: 17
view all 7 authors...
The quantitative measurement of structural alterations at the nanoscale level is important for understanding the physical state of biological samples. Studies have shown that the progression of cancer is associated with the rearrangements of building blocks of cells/tissues such as DNA, RNA, lipids, etc. Partial wave spectroscopy is a recently developed mesoscopic physics-based spectroscopic imaging technique which can detect such nanoscale changes in cells/tissues. At present, chemotherapy drug...
7 CitationsSource