Eleanor J. Molloy
Trinity College, Dublin
Vitamin D and neurologyInternal medicineEndocrinologyCardiologyIntensive care medicinePediatricsImmunologyInflammationNeonatal encephalopathySepsisLow birth weightPregnancyMEDLINEPopulationAnesthesiaIncidence (epidemiology)GestationBirth weightMedicineGastroenterology
Publications 337
#1Megan Ní Bhroin (Trinity College, Dublin)H-Index: 3
#2Lynne Kelly (Trinity College, Dublin)H-Index: 8
Last. Gabrielle Colleran (UCD: University College Dublin)
view all 12 authors...
Abstract null Background null Magnetic resonance imaging (MRI) scoring systems are used in the neonatal period to predict outcome in infants with neonatal encephalopathy (NE). Our aim was to assess the relationship between 3 MRI scores and neurodevelopmental outcome assessed using Bayley Scales of Infant and Toddler Development, third edition (Bayley-III) at 2 years in infants with NE. null Methods null Term-born neonates with evidence of perinatal asphyxia born between 2011 to 2015 were retrosp...
#1Rían Hayes (Trinity College, Dublin)H-Index: 1
#2Jack Hartnett (Trinity College, Dublin)H-Index: 2
Last. ImmunisationH-Index: 1
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Introduction null Neonatal sepsis is a leading cause of infant mortality worldwide with non-specific and varied presentation. We aimed to catalogue the current definitions of neonatal sepsis in published randomised controlled trials (RCTs). null Method null A systematic search of the Embase and Cochrane databases was performed for RCTs which explicitly stated a definition for neonatal sepsis. Definitions were sub-divided into five primary criteria for infection (culture, laboratory findings, cli...
#1Cynthia F. Bearer (Boston Children's Hospital)H-Index: 30
#2Eleanor J. Molloy (UCD: University College Dublin)H-Index: 28
#1Ashanty M Melo (Trinity College, Dublin)H-Index: 9
#2Nawal A.B. Taher (Trinity College, Dublin)H-Index: 1
Last. Eleanor J. MolloyH-Index: 28
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Abstract null null Neonatal encephalopathy is a syndrome characterised by abnormal neurological function often caused by a hypoxic insult during childbirth. Triggers such as hypoxia-ischaemia result in the release of cytokines and chemokines inducing the infiltration of neutrophils, natural killer cells, B cells, T cells and innate T cells into the brain. However, the role of these cells in the development of the brain injury is poorly understood. We review the mechanisms by which lymphocytes co...
#1Barbara D. Friedes (JHUSOM: Johns Hopkins University School of Medicine)
#2Eleanor J. Molloy (Trinity College, Dublin)H-Index: 28
Last. Allen D. Everett (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 20
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Background null To investigate mechanisms of injury and recovery in neonatal encephalopathy (NE), we performed targeted metabolomic analysis of plasma using liquid chromatography with tandem mass spectrometry (LC/MS/MS) from healthy term neonates or neonates with NE. null Methods null Plasma samples from the NE (n = 45, day of life 0-1) or healthy neonatal (n = 30, ≥36 weeks gestation) cohorts had LC/MS/MS metabolomic profiling with a 193-plex targeted metabolite assay covering >366 metabolic pa...
BackgroundIreland is thought to have amongst the highest incidence of Down syndrome (DS) in the world. Children with DS have many healthcare needs and associated conditions. DS medical management guidelines have been developed to optimise the health of children with DS. A national Register was established in 2015 to define the incidence of DS in the Irish population and undertake prospective monitoring of health issues and healthcare utilisation.ObjectivesThe purpose of this study is to explore ...
#1Melissa E Barnes (UCD: University College Dublin)
#2Emily Feeney (UCD: University College Dublin)
Last. Eleanor J. MolloyH-Index: 28
view all 14 authors...
AIM Pulmonary haemorrhage (PH) is an acute catastrophic event with low incidence yet high mortality among neonates. We aimed to systematically review the management of PH. METHODS A search was carried out of the PubMed, EMBASE and Cochrane databases according to the PRISMA guidelines. Data were extracted on study design and size, patient demographics, primary and adjunctive treatment methods, and treatment outcomes. RESULTS Sixteen studies with 385 newborn infants were included and were signific...
#1Deirdre SweetmanH-Index: 10
#2Tammy Strickland (Trinity College, Dublin)H-Index: 5
Last. Afif El-Khuffash (RCSI: Royal College of Surgeons in Ireland)H-Index: 30
view all 11 authors...
AIM Neonatal encephalopathy (NE) is associated with an increased risk of multi-organ injury. The lack of standardised definitions for multi-organ dysfunction in NE hinders accurate quantification of these complications. METHODS A simple multi-organ dysfunction in neonatal encephalopathy scoring (MODE) system was created to include the cardiovascular, respiratory, gastrointestinal, haematological and neurological systems with a maximum score of 15. The MODE score was then compared with the grade ...
#1Edward Beamer (University of Medicine and Health Sciences)H-Index: 3
#2Mary O'DeaH-Index: 3
Last. Eva M. Jimenez-Mateos (Trinity College, Dublin)H-Index: 30
view all 17 authors...
Background: Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). Current diagnostic tests are, however, mainly restricted to clinical diagnosis with no molecular tests available. Purines including adenosine are released during brain injury such as hypoxia and are also present in biofluids. Whether blood purine changes can be used to diagnose NE has not been investi...
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