Alessandro Palmioli
University of Milan
Atomic force microscopySurface plasmon resonanceComplement systemBiological activityLigand (biochemistry)BiophysicsGlycoconjugateMolecular biologyMonomerReceptorNutraceuticalChemistryMannan-binding lectinStructure–activity relationshipEpitopeIn vitroImmunologyLectin pathwayCombinatorial chemistryEx vivoMannoseGlycomimeticSugarEchinochloa oryzoidesMetaboliteAntioxidantAmideBombesinLolium multiflorumPeucedanum ostruthiumLectinRas InhibitorChemoprotectiveFood scienceChemical engineeringChromatographyRheniumNucleotideEffectorBiochemistryTraditional medicineDendrimerPharmacophoreNuclear magnetic resonance spectroscopyPolyphenolStereochemistryLigandBiologyScaffoldCell biologyCancer cell
Publications 42
#1Sara Vitalini (University of Milan)H-Index: 23
#2Alessandro Palmioli (University of Milan)H-Index: 14
Last. Marcello IritiH-Index: 56
view all 8 authors...
Abstract Peucedanum ostruthium (L.) W.D.J.Koch (Apiaceae) is an alpine medicinal plant traditionally used as a panacea to treat various ailments. For the first time, its phytotoxic and nematotoxic properties were investigated. The inhibitory activity toward germination and seedling growth of the weeds Echinochloa oryzoides (Ard.) Fritsch and Lolium multiflorum Lam. was evaluated by two in vitro assays, carried out on filter paper and soil, using different aqueous extract concentrations (1, 10, a...
#1Alessandro PalmioliH-Index: 14
#2Paola SperandeoH-Index: 18
Last. Cristina AiroldiH-Index: 26
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Abstract We describe the development of an on-cell NMR method for the rapid screening of FimH ligands and the structural identification of ligand binding epitopes. FimH is a mannose-binding bacterial adhesin expressed at the apical end of type 1 pili of uropathogenic bacterial strains and responsible for their d -mannose sensitive adhesion to host mammalian epithelial cells. Because of these properties, FimH is a key virulence factor and an attractive therapeutic target for urinary tract infecti...
#1Cristina AiroldiH-Index: 26
#2Alessandro PalmioliH-Index: 14
1 CitationsSource
#1Alessio Malacrida (University of Milano-Bicocca)H-Index: 6
#2S. Semperboni (University of Milano-Bicocca)H-Index: 5
Last. Gabriella Nicolini (University of Milano-Bicocca)H-Index: 25
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Proteasome inhibitors (PIs) represent the gold standard in the treatment of multiple myeloma. Among PIs, Bortezomib (BTZ) is frequently used as first line therapy, but peripheral neuropathy (PN), occurring approximately in 50% of patients, impairs their life, representing a dose-limiting toxicity. Carfilzomib (CFZ), a second-generation PI, induces a significantly less severe PN. We investigated possible BTZ and CFZ off-targets able to explain their different neurotoxicity profiles. In order to i...
#1Carlotta Ciaramelli (University of Milano-Bicocca)H-Index: 11
#2Alessandro Palmioli (University of Milano-Bicocca)H-Index: 14
Last. Cristina Airoldi (University of Milano-Bicocca)H-Index: 26
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Abstract The metabolic profile of Lavado cocoa was characterized for the first time by NMR spectroscopy, then compared with the profiles of fermented and processed varieties, Natural and commercial cocoa. The significant difference in the contents of theobromine and flavanols prompted us to examine the various cocoa varieties to seek correlations between these metabolite concentrations and the anti-amyloidogenic activity reported for cocoa in the literature. We combined NMR spectroscopy, prepara...
1 CitationsSource
#1Alessandro Palmioli (University of Milano-Bicocca)H-Index: 14
#2Gabriella Nicolini (University of Milano-Bicocca)H-Index: 25
Last. Cristina Airoldi (University of Milano-Bicocca)H-Index: 26
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We report the rational design, synthesis, and in vitro preliminary evaluation of a new small library of non-peptide ligands of Gastrin Releasing Peptide Receptor (GRP-R), able to antagonize its natural ligand bombesin (BN) in the nanomolar range of concentration. GRP-R is a transmembrane G-protein coupled receptor promoting the stimulation of cancer cell proliferation. Being overexpressed on the surface of different human cancer cell lines, GRP-R is ideal for the selective delivery to tumor cell...
#1Renata TisiH-Index: 15
#2Michela Spinelli (University of Milan)H-Index: 2
Last. Elena SaccoH-Index: 11
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Ras oncoproteins play a crucial role in the onset, maintenance, and progression of the most common and deadly human cancers. Despite extensive research efforts, only few mutant-specific Ras inhibitors have been reported. We show that cmp4 – previously identified as a water-soluble Ras inhibitor– targets multiple steps in the activation and downstream signaling of different Ras mutants and isoforms. Binding of this pan-Ras inhibitor to an extended Switch II pocket on HRas and KRas proteins induce...
#1Alessia D’Aloia (University of Milano-Bicocca)H-Index: 5
#2Federica Arrigoni (University of Milano-Bicocca)H-Index: 9
Last. Laura Cipolla (University of Milano-Bicocca)H-Index: 26
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Palmitoylethanolamide (PEA) belongs to the class of N-acylethanolamine and is an endogenous lipid potentially useful in a wide range of therapeutic areas; products containing PEA are licensed for use in humans as a nutraceutical, a food supplement, or food for medical purposes for its analgesic and anti-inflammatory properties demonstrating efficacy and tolerability. However, the exogenously administered PEA is rapidly inactivated; in this process, fatty acid amide hydrolase (FAAH) plays a key r...
1 CitationsSource
#1Cristina AiroldiH-Index: 26
#2Carlotta CiaramelliH-Index: 11
Last. Alessandro PalmioliH-Index: 14
view all 0 authors...
2 CitationsSource
#1Sara Vitalini (University of Milan)H-Index: 23
#2Francesca Orlando (University of Brescia)H-Index: 2
Last. Marcello Iriti (University of Milan)H-Index: 56
view all 9 authors...