Karen Dyker
St James's University Hospital
CancerInternal medicineRadiologySurgeryOncologyRetrospective cohort studyStage (cooking)Head and neck cancerInduction chemotherapyChemotherapyHead and neck squamous-cell carcinomaCarcinomaCisplatinChemoradiotherapyNeck dissectionLymph nodeOropharyngeal CarcinomaNuclear medicinePatterns of failureRadiation therapyMedicine
53Publications
14H-index
751Citations
Publications 51
Newest
#2Louise Murray (University of Leeds)H-Index: 18
Last. Robin PrestwichH-Index: 28
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Abstract Aims To analyse outcomes and patterns of failure in patients with oropharyngeal carcinoma (OPC) treated with definitive volumetric modulated arc therapy with omission of contralateral high level II lymph nodes (HLII) and retropharyngeal lymph nodes (RPLN) in the contralateral uninvolved neck. Materials and methods Patients with OPC treated between January 2016 and July 2019 were retrospectively identified. In the absence of contralateral neck disease, institutional protocols allowed omi...
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#1Metin FigenH-Index: 2
#2Didem Çolpan Öksüz (Istanbul University)H-Index: 10
Last. Mehmet ŞenH-Index: 1
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Purpose and Objective: A proportion of patients receiving radiotherapy for head and neck squamous cell carcinoma (HNSCC) require ad hoc treatment replanning. The aim of this retrospective study is to analyse the patients who required ad hoc replanning and identify factors which may predict need for replanning. Materials and Methods: A single centre evaluation of all patients receiving radical or adjuvant (chemo)radiotherapy (CRT) for HNSCC between January-December 2016 was undertaken. Patients w...
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#2Louise MurrayH-Index: 18
Last. Robin PrestwichH-Index: 28
view all 7 authors...
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#1R. Waldram (University of Leeds)H-Index: 1
#2A.E. Taylor (University of Leeds)H-Index: 1
Last. Robin PrestwichH-Index: 28
view all 13 authors...
Abstract Aims To evaluate patterns of locoregional recurrence following adjuvant (chemo)radiotherapy for oral cavity squamous cell carcinomas. Materials and methods One hundred and one patients who received adjuvant radiotherapy ± chemotherapy for oral cavity squamous cell carcinoma between 2013 and 2016 were analysed. For documented locoregional recurrence, recurrence imaging was deformably co-registered to the planning computed tomography scan. The volume of recurrence was delineated (Vrec). V...
5 CitationsSource
#1Jim Zhong (Leeds Teaching Hospitals NHS Trust)H-Index: 5
#2Moses SundersinghH-Index: 1
Last. Andrew Scarsbrook (University of Leeds)H-Index: 29
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There is no consensus regarding optimal interpretative criteria (IC) for Fluorine-18 fluorodeoxyglucose (FDG) Positron Emission Tomography – Computed Tomography (PET-CT) response assessment following (chemo)radiotherapy (CRT) for head and neck squamous cell carcinoma (HNSCC). The aim was to compare accuracy of IC (NI-RADS, Porceddu, Hopkins, Deauville) for predicting loco-regional control and progression free survival (PFS). All patients with histologically confirmed HNSCC treated at a specialis...
6 CitationsSource
#1Robin Prestwich (St James's University Hospital)H-Index: 28
#2M. ArunsinghH-Index: 5
Last. Andrew Scarsbrook (University of Leeds)H-Index: 29
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Objectives The limited positive predictive value of an incomplete response on PET-CT following (chemo)radiotherapy for head and neck squamous cell carcinoma (HNSCC) means that the optimal management strategy remains uncertain. The aim of the study is to assess the utility of a ‘second-look’ interval PET-CT.
2 CitationsSource
#2Louise MurrayH-Index: 18
Last. Robin PrestwichH-Index: 28
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The influence of retropharyngeal lymph node (RPLN) involvement on prognosis in oropharyngeal carcinoma remains poorly defined. The aim of this study was to assess the impact of RPLN involvement upon outcomes. A single-centre retrospective analysis of 402 patients with oropharyngeal carcinoma treated nonsurgically between 2010 and 2017 was performed. All had a baseline 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (FDG) PET-CT and contrast-enhanced MRI and/or CT. RPLN status was determined by radiolog...
2 CitationsSource
#1S. RamasamyH-Index: 6
#2Louise MurrayH-Index: 18
Last. Robin PrestwichH-Index: 28
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Abstract Aims To assess the impact of weekly scheduled peer review of head and neck contours for definitive and adjuvant radiotherapy cases based on rates of recommended changes. Materials and methods Retrospective analysis of a prospective database. Recommended changes were prospectively classified as ‘major’ (change in gross tumour volume and/or high-dose clinical target volume, dose/fractionation) or ‘minor’ (change in intermediate or elective dose clinical target volumes or organs at risk). ...
3 CitationsSource
#1Anthony Kong (University of Birmingham)H-Index: 20
#2Pankaj Mistry (Warw.: University of Warwick)H-Index: 4
Last. Hisham Mehanna (University of Birmingham)H-Index: 44
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6076Background: The De-ESCALaTE trial confirmed the superiority of cisplatin over cetuximab in combination with radiotherapy for the treatment of low risk human papillomavirus positive oropharyngea...
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#1Robin PrestwichH-Index: 28
#2Louise MurrayH-Index: 18
Last. S. RamasamyH-Index: 6
view all 11 authors...
AbstractBackground: Prior reports have raised concerns that a prophylactic gastrostomy may be detrimental to long-term swallow function. This study evaluates patient-reported swallow function follo...
1 CitationsSource