José González-Valdez
Monterrey Institute of Technology and Higher Education
RNase PNanotechnologyAffinity chromatographyBiochemical engineeringAqueous solutionChemistryMaterials scienceMicrovesiclesPolyethylene glycolPEGylationContext (language use)ExosomeComputer scienceChemical engineeringChromatographyPhase (matter)PolymerPEG ratioMicrofluidicsFractionation
55Publications
14H-index
406Citations
Publications 55
Newest
#1Ana Mayela Ramos-de-la-Peña (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 3
#2Oscar Aguilar (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 17
Last. José González-Valdez (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 14
view all 3 authors...
Abstract null null Nucleation and crystal growth of edible fats at the nanoscale have received little attention due to analytical limitations. A key factor to modify the properties of edible fats is nanostructure understanding. Progress within the last years will be presented, including null analytical techniques used to investigate fat crystallization. Cocoa butter has been the subject of several works due to its properties and its high impact on chocolate manufacturing. Moreover, this vegetabl...
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#1Ana Mayela Ramos-de-la-Peña (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 3
#2Oscar Mario Mercado-Valenzo (Tec: Monterrey Institute of Technology and Higher Education)
Last. Oscar Aguilar (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 17
view all 8 authors...
A laboratory exercise for undergraduate advanced students of enzymology and biocatalysis is presented. Since enzyme assays can be quenched or continuous, this experiment compares the performance of two quenching agents for lactase, in a continuous setup. Enzymatic activity of β-galactosidase (Aspergillus oryzae) was determined based on the release of 4-nitrophenol from 4-nitrophenyl β-D-galactopyranoside using a microplate reader. Sodium carbonate and borate buffer were tested as quenching agent...
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#1Javier Donoso-Quezada (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 3
#2Sergio Ayala-Mar (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 5
Last. José González-Valdez (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 14
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Exosomes are extracellular vesicles that in recent years have received special attention for their regulatory functions in numerous biological processes. Recent evidence suggests a correlation between the composition of exosomes in body fluids and the progression of some disorders, such as cancer, diabetes, and neurodegenerative diseases. In consequence, numerous studies have been performed to evaluate the composition of these vesicles, aiming to develop new biomarkers for diagnosis and to find ...
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#1Celeste C. Ibarra-Herrera (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 4
#2Aranza Meza-Dorantes (Tec: Monterrey Institute of Technology and Higher Education)
Last. Marco A. Mata-Gómez (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 7
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The natural triterpene pristimerin possesses interesting potential against several types of cancer. However, its production at the industrial level requires novel environmentally friendly and effic...
1 CitationsSource
Last. José González-Valdez (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 14
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Abstract This work aims to study the bio-interfacial properties of poly(ester-urethane) composite scaffolds based on poly (3-hydroxybutyrate) [PHB] and modified by surface plasma-radiation-induced graft polymerization of N-isopropylacrylamide (NIPAAm). The delivering power of the Argon radio-frequency plasma was increased from 5−20 W. The yields over the polyurethane surface, grafting density, topographical dimensions, architecture, surface energy, and wettability were surveyed in the establishe...
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#1Alan Roberto Marquez-Ipiña (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 3
#2Everardo González-González (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 6
Last. Grissel Trujillo-de Santiago (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 17
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Massive worldwide serological testing for SARS-CoV-2 is needed to determine the extent of virus exposure in a particular region, the ratio of symptomatic to asymptomatic infected persons, and the duration and extent of immunity after infection. To achieve this, the development and production of reliable and cost-effective SARS-CoV-2 antigens is critical. We report the bacterial production of the peptide S-RBDN318-V510, which contains the receptor-binding domain of the SARS-CoV-2 spike protein (r...
2 CitationsSource
#1Sergio Ayala-Mar (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 5
#2Javier Donoso-Quezada (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 3
Last. José González-Valdez (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 14
view all 3 authors...
Inhibiting the programmed cell death ligand-1 (PD-L1)/programmed cell death receptor-1 (PD-1) signaling axis reinvigorates the antitumor immune response with remarkable clinical efficacy. Yet, low response rates limit the benefits of immunotherapy to a minority of patients. Recent studies have explored the importance of PD-L1 as a transmembrane protein in exosomes and have revealed exosomal PD-L1 as a mechanism of tumor immune escape and immunotherapy resistance. Exosomal PD-L1 suppresses T cell...
3 CitationsSource
Abstract Droplet-based microfluidics is an emerging field that has found its way in different applications like material science and biotechnology. Knowing how factors like capillary number, surface tension, velocity ratio, viscosity ratio, and contact angle affect droplet formation is of upmost importance for the design of microfluidic platforms. In this study, we evaluate how these factors affect droplet formation by using the two-phase level set method, measuring its length and frequency. Add...
2 CitationsSource
#1Javier Donoso-Quezada (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 3
#2Daniel Guajardo-Flores (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 9
Last. José González-Valdez (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 14
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Exosomes are a subpopulation of membrane-derived cellular vesicles (30-150 nm) that play an important role in intercellular communication. Because of their natural function as nanocarriers, several applications have been developed for these nanovesicles, including drug delivery. Here we loaded saponins and flavonoids obtained from a black bean extract (Phaseolus vulgaris L.) with antiproliferative activity into exosomes extracted from different cell lines to induce an enhanced response in vitro....
3 CitationsSource