Napoleone Ferrara
University of California, San Diego
Vascular endothelial growth factor CCancerEndothelial stem cellInternal medicineEndocrinologyPathologyVascular endothelial growth factor AVascular endothelial growth factor BMolecular biologyReceptorChemistryImmunologyGrowth factorEndotheliumVascular endothelial growth factorNeovascularizationAngiogenesisCancer researchMedicineBiologyCell biology
371Publications
179H-index
125kCitations
Publications 362
Newest
#1Xueping Qu (Genentech)H-Index: 4
#2Guanglei ZhuangH-Index: 25
Last. Napoleone FerraraH-Index: 179
view all 5 authors...
Bv8, also known as prokineticin 2, has been characterized as an important mediator of myeloid cell mobilization and myeloid cell-dependent tumor angiogenesis. Bv8 expression is dramatically enhanced by G-CSF, both in vitro and in vivo. The mechanisms involved in such up-regulation remain unknown. Using pharmacological inhibitors that interfere with multiple signaling pathways known to be activated by G-CSF, we show that signal transducer and activator of transcription 3 (Stat3) activation is req...
48 CitationsSource
#1Napoleone Ferrara (Genentech)H-Index: 179
Angiogenesis is a fundamental process in embryonic and adult life and is also important for tissue repair [1, 2]. Normal microvessels are organized as highly ordered structures consisting of endothelial cells, pericytes, and basement membrane. Pericytes are required for vascular stabilization through establishment of contact with endothelial cells along the length of the vessels and also through paracrine signaling [3]. Angiogenesis is a relatively rare event in the adult, except in particular c...
1 CitationsSource
#1Michal Milgrom-Hoffman (Weizmann Institute of Science)H-Index: 4
#2Zachary Harrelson (UCSD: University of California, San Diego)H-Index: 4
Last. Eldad TzahorH-Index: 30
view all 6 authors...
The embryonic heart is composed of two cell layers: the myocardium, which contributes to cardiac muscle tissue, and the endocardium, which covers the inner lumen of the heart. Whereas significant progress has been made toward elucidating the embryonic origins of the myocardium, the origins of the endocardium remain unclear. Here, we have identified an endocardium-forming field medial to the cardiac crescent, in a continuum with the endothelial plexus. In vivo live imaging of quail embryos reveal...
79 CitationsSource
The formation of the vascular network is an intricate and complex process that is an obligate requirement during vertebrate development. The cardiovascular system is the first organ to develop and reach a functional state, which underscores the crucial role of the vasculature in the developing embryo. The development of the vasculature into highly branched conduits needs to occur in numerous sites and in precise patterns to supply oxygen and nutrients to the rapidly expanding tissue of the embry...
464 CitationsSource
#1Sujata Rao (Cincinnati Children's Hospital Medical Center)H-Index: 10
#1Sujata Rao (Cincinnati Children's Hospital Medical Center)H-Index: 19
Last. Richard A. LangH-Index: 79
view all 6 authors...
Source
PlGF, one of the ligands for VEGFR-1, has been implicated in tumor angiogenesis. However, more recent studies indicate that genetic or pharmacological inhibition of PlGF signaling does not result in reduction of microvascular density in a variety of tumor models. Here we screened 12 human tumor cell lines and identified 3 that are growth inhibited by anti-PlGF antibodies in vivo. We found that efficacy of anti-PlGF treatment strongly correlates with VEGFR-1 expression in tumor cells, but not wit...
79 CitationsSource
#1Vanessa M. BrauerH-Index: 3
#2Ningxia LuH-Index: 5
Last. Andrea S. CuppH-Index: 25
view all 6 authors...
Source
#1Kevin M. SargentH-Index: 5
#2Ningxia LuH-Index: 5
Last. Andrea S. CuppH-Index: 25
view all 8 authors...
Source
#1James A. Stefater (UC: University of Cincinnati)H-Index: 7
#2Ian P. Lewkowich (Cincinnati Children's Hospital Medical Center)H-Index: 20
Last. Richard A. Lang (UC: University of Cincinnati)H-Index: 79
view all 16 authors...
Richard Lang and colleagues identify a mechanism by which myeloid cells regulate the pattern of blood-vessel branching in the post-natal retina. They show that macrophages inhibit branching by secreting Wnt ligands that use a non-canonical pathway to induce secretion of the VEGF inhibitory receptor Flt1. Myeloid cells are a feature of most tissues. Here we show that during development, retinal myeloid cells (RMCs) produce Wnt ligands to regulate blood vessel branching. In the mouse retina, where...
195 CitationsSource
#1Lanlan Yu (Genentech)H-Index: 13
#2Xiao Huan Liang (Genentech)H-Index: 7
Last. Napoleone Ferrara (Genentech)H-Index: 179
view all 3 authors...
Abstract VEGF inhibitors are widely used as a therapy for tumors and intravascular neovascular disorders, but limited and conflicting data regarding their relative biological potencies are available. The purpose of the study is to compare different protein VEGF inhibitors for their ability to inhibit VEGF-stimulated activities. We tested ranibizumab, the full-length variant of ranibizumab (Mab Y0317), bevacizumab, the VEGF-TrapR1R2 and Flt(1-3)-IgG in bioassays measuring VEGF-stimulated prolifer...
73 CitationsSource