Napoleone Ferrara
University of California, San Diego
Vascular endothelial growth factor CCancerEndothelial stem cellInternal medicineEndocrinologyPathologyVascular endothelial growth factor AVascular endothelial growth factor BMolecular biologyReceptorImmunologyGrowth factorEndotheliumVascular endothelial growth factorNeovascularizationAngiogenesisCancer researchMedicineBiologyCell biology
371Publications
179H-index
125kCitations
Publications 362
Newest
#1Hong Xin (UCSD: University of California, San Diego)H-Index: 2
#2Nilima Biswas (UCSD: University of California, San Diego)H-Index: 16
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 7 authors...
Neovascularization is a key feature of ischemic retinal diseases and the wet form of age-related macular degeneration (AMD), all leading causes of severe vision loss. Vascular endothelial growth factor (VEGF) inhibitors have transformed the treatment of these disorders. Millions of patients have been treated with these drugs worldwide. However, in real-life clinical settings, many patients do not experience the same degree of benefit observed in clinical trials, in part because they receive fewe...
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#1Sergii Domanskyi (MSU: Michigan State University)H-Index: 7
#2Alex Hakansson (DI: Discovery Institute)H-Index: 1
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 7 authors...
VEGF inhibitor drugs have been successful, especially in ophthalmology, but not all patients respond to them. Combinations of drugs are likely to be needed for a really effective therapy of angiogenesis-related diseases. In this paper we describe naturally occurring combinations of receptors in endothelial cells that might help to identify targets for drug combinations. We also develop and share a new computational method and a software tool called DECNEO to identify them. Single-cell gene expre...
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#1Wei LiangH-Index: 10
#2Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
Cells of the innate immune system are a major component of the tumor microenvironment. They play complex and multifaceted roles in the regulation of cancer initiation, growth, metastasis and responses to therapeutics. Innate immune cells like neutrophils and macrophages are recruited to cancerous tissues by chemotactic molecules released by cancer cells and cancer-associated stromal cells. Once they reach the tumor, they can be instructed by a network of proteins, nucleic acids and metabolites t...
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#1Sergii Domanskyi (UCSD: University of California, San Diego)H-Index: 7
#1S. Domanskyi (UCSD: University of California, San Diego)
Last. N. Ferrara (UCSD: University of California, San Diego)
view all 7 authors...
VEGF inhibitor drugs have been successful, especially in ophthalmology, but not all patients respond to them. Combinations of drugs are likely to be needed for a really effective therapy of angiogenesis-related diseases. In this paper we introduce a new concept, the comberon, a term named by analogy with the operon that refers to evolutionarily conserved combinations of co-expressed genes. These genes identify potential drug targets. Our results show that single-cell gene expression data can hel...
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#1Zhong Cuiling (UCSD: University of California, San Diego)H-Index: 2
#2Pin Li (UCSD: University of California, San Diego)H-Index: 1
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 10 authors...
Endothelial cell (EC) metabolism is thought to be one of the driving forces for angiogenesis. Here we report the identification of the hexosamine D-mannosamine (ManN) as an EC mitogen and survival factor for bovine and human microvascular EC, with an additivity with VEGF. ManN inhibits glycosylation in ECs and induces significant changes in N-glycan and O-glycan profiles. We further demonstrate that ManN and two N-glycosylation inhibitors stimulate EC proliferation via both JNK activation and th...
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#1Mara Gilardi (UCSD: University of California, San Diego)H-Index: 11
#2Zhiyong Wang (UCSD: University of California, San Diego)H-Index: 24
Last. Francis BurrowsH-Index: 29
view all 14 authors...
Tipifarnib is a potent and highly selective inhibitor of farnesyltransferase (FT). FT catalyzes the post-translational attachment of farnesyl groups to signaling proteins that are required for localization to cell membranes. Although all RAS isoforms are FT substrates, only HRAS is exclusively dependent upon farnesylation, raising the possibility that HRAS mutant tumors might be susceptible to tipifarnib-mediated inhibition of FT. Here, we report the characterization of tipifarnib activity in a ...
8 CitationsSource
#1Yoshiro Itatani (UCSD: University of California, San Diego)H-Index: 16
#2Takamasa Yamamoto (UCSD: University of California, San Diego)H-Index: 5
Last. Napoleone Ferrara (UC: University of California)
view all 8 authors...
We tested cis-ApcΔ716/Smad4+/− and cis-ApcΔ716/Smad4+/−KrasG12D mice, which recapitulate key genetic abnormalities accumulating during colorectal cancer (CRC) tumorigenesis in humans, for responsiveness to anti-VEGF therapy. We found that even tumors in cis-ApcΔ716/Smad4+/−KrasG12D mice, although highly aggressive, were suppressed by anti-VEGF treatment. We tested the hypothesis that inflammation, a major risk factor and trigger for CRC, may affect responsiveness to anti-VEGF. Chemically induced...
2 CitationsSource
#1Yoshiro ItataniH-Index: 16
#2Takamasa YamamotoH-Index: 5
Last. Napoleone FerraraH-Index: 179
view all 3 authors...
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#1Nicholas J. Protopsaltis (UCSD: University of California, San Diego)H-Index: 2
#2Wei Liang (UCSD: University of California, San Diego)H-Index: 10
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 4 authors...
TH17 cells play important yet complex roles in cancer development and progression. We previously reported that TH17 cells and IL-17 mediate resistance to anti-VEGF therapy by inducing recruitment of immunosuppressive and proangiogenic myeloid cells to the tumor microenvironment. Here, we demonstrate that IL-22, a key effector cytokine expressed by TH17 cells, directly acts on endothelial cells to promote tumor angiogenesis. IL-22 induces endothelial cell proliferation, survival, and chemotaxis i...
9 CitationsSource
#1Rajendra S. Apte (WashU: Washington University in St. Louis)H-Index: 37
#2Daniel S. ChenH-Index: 40
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 3 authors...
The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our understanding of vasculogenesis and angiogenesis during development and physiological homeostasis. Over a short span of two decades, our understanding of the molecular mechanisms by which VEGF coordinates neurovascular homeostasis has become more sophisticated. The central role of VEGF in the pathogenesis of diverse cancers and blinding eye diseases has also become evident. Elucidation of the molecular regu...
274 CitationsSource