Ignat Drozdov
King's College London
Internal medicineEndocrinologyPathologyOncologyTranscriptomeProgressive diseaseNeuroendocrine tumorsDiseaseLiquid biopsyRadionuclide therapyGene clusterSecretionCancer researchComputational biologyMedicineBiomarker (medicine)Chromogranin ABiologyGastroenterologyCell biology
147Publications
37H-index
5,558Citations
Publications 146
Newest
#1Mélanie Abonnenc ('KCL': King's College London)H-Index: 4
#2Adam NabeebaccusH-Index: 12
Last. Manuel MayrH-Index: 81
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Rationale: MicroRNAs (miRNAs), in particular miR-29b and miR-30c, have been implicated as important regulators of cardiac fibrosis. Objective: To perform a proteomics comparison of miRNA effects on extracellular matrix (ECM) secretion by cardiac fibroblasts (CFs). Methods and Results: Mouse CFs were transfected with pre-/anti-miR of miR-29b and miR-30c and their conditioned medium was analysed by mass spectrometry. MiR-29b targeted a cadre of proteins involved in fibrosis, including multiple col...
131 CitationsSource
#1Irvin M. Modlin (Yale University)H-Index: 81
#2Ignat Drozdov (Yale University)H-Index: 37
Last. Mark Kidd (Yale University)H-Index: 66
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4137 Background: Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) or NETs (also called “carcinoids”) are problematic since they present with advanced disease and have limited treatment ...
19 CitationsSource
#1Irvin M. Modlin (Yale University)H-Index: 81
#2Ignat Drozdov (Yale University)H-Index: 37
Last. Mark Kidd (Yale University)H-Index: 66
view all 3 authors...
Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are increasing in both incidence and prevalence. A delay in correct diagnosis is common for these lesions. This reflects the absence of specific blood biomarkers to detect NENs. Measurement of the neuroendocrine secretory peptide Chromogranin A (CgA) is used, but is a single value, is non-specific and assay data are highly variable. To facilitate tumor detection, we developed a multi-transcript molecular signature for PCR-based blood a...
110 CitationsSource
#1Yiwen Liu ('KCL': King's College London)H-Index: 7
#2Ignat Drozdov ('KCL': King's College London)H-Index: 37
Last. Catherine M. Shanahan ('KCL': King's College London)H-Index: 79
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Rationale: Vascular calcification is prevalent in the aging population, yet little is known of the mechanisms driving age-associated vascular smooth muscle cell (VSMC) phenotypic change. Objective: To investigate the role of nuclear lamina disruption, a specific hallmark of VSMC aging, in driving VSMC osteogenic differentiation. Methods and Results: Prelamin A, the unprocessed form of the nuclear lamina protein lamin A, accumulated in calcifying human VSMCs in vitro and in vivo, and its overexpr...
137 CitationsSource
#1Alexander N. Kapustin ('KCL': King's College London)H-Index: 15
#2Martijn L. Chatrou (UM: Maastricht University)H-Index: 11
Last. Catherine M. Shanahan ('KCL': King's College London)H-Index: 79
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Vascular calcification is a regulated pathological process similar to bone formation which is mediated by vascular smooth muscle cells (VSMCs) undergoing osteogenic transdifferentiation. Initiation of vascular calcification occurs in small membrane-bound matrix vesicles (MVs), secreted by VSMCs into the extracellular matrix however the mechanisms regulating MV biogenesis and secretion are unclear. Fetuin-A, a circulating protein abundant in MVs was used to trace the origin of VSMC-derived MVs. A...
Source
#1Øystein BrennaH-Index: 5
#2Marianne W. FurnesH-Index: 9
Last. Bjorn I. GustafssonH-Index: 27
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Source
#1Friederike Cuello (UHH: University of Hamburg)H-Index: 26
#2Ursula Mayr ('KCL': King's College London)H-Index: 22
Last. Marius TerblancheH-Index: 13
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#1Sarah R. Langley ('KCL': King's College London)H-Index: 25
#2Joseph Dwyer ('KCL': King's College London)H-Index: 7
Last. Manuel Mayr ('KCL': King's College London)H-Index: 81
view all 5 authors...
The conventional reductionist approach to cardiovascular research investigates individual candidate factors or linear signalling pathways but ignores more complex interactions in biological systems. The advent of molecular profiling technologies that focus on a global characterization of whole complements allows an exploration of the interconnectivity of pathways during pathophysiologically relevant processes, but has brought about the issue of statistical analysis and data integration. Proteins...
52 CitationsSource
#1Atle van Beelen Granlund (NTNU: Norwegian University of Science and Technology)H-Index: 13
#2Arnar Flatberg (NTNU: Norwegian University of Science and Technology)H-Index: 16
Last. Arne K. Sandvik (NTNU: Norwegian University of Science and Technology)H-Index: 45
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© 2013 Granlund et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
85 CitationsSource
#1Xiaoke Yin ('KCL': King's College London)H-Index: 44
#2Joseph Dwyer ('KCL': King's College London)H-Index: 7
Last. Manuel Mayr ('KCL': King's College London)H-Index: 81
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Perhexiline is a potent anti-anginal drug used for treatment of refractory angina and other forms of heart disease. It provides an oxygen sparing effect in the myocardium by creating a switch from fatty acid to glucose metabolism through partial inhibition of carnitine palmitoyltransferase 1 and 2. However, the precise molecular mechanisms underlying the cardioprotective effects elicited by perhexiline are not fully understood. The present study employed a combined proteomics, metabolomics and c...
28 CitationsSource