Norma Velázquez-Guadarrama
Boston Children's Hospital
GeneDrug resistanceSCCmecGenotypeHumanitiesVirologyAllelePhylogenetic treeImmunologyHelicobacter pyloriMethicillin-resistant Staphylococcus aureusCongenital cytomegalovirus infectionCagAGastritisVancomycinStaphylococcus aureusStreptococcus pneumoniaeEnterococcus sppGenotypingPulsed-field gel electrophoresisAntibioticsBacteriaGeneticsVirulenceMedicineBiologyMicrobiologyMultiplex polymerase chain reaction
22Publications
9H-index
173Citations
Publications 24
Newest
Microbiomes are defined as complex microbial communities, which are mainly composed of bacteria, fungi, and viruses residing in diverse regions of the human body. The human stomach consists of a unique and heterogeneous habitat of microbial communities owing to its anatomical and functional characteristics, that allow the optimal growth of characteristic bacteria in this environment. Gastric dysbiosis, which is defined as compositional and functional alterations of the gastric microbiota, can be...
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#1Sandra Mendoza-Elizalde (IPN: Instituto Politécnico Nacional)H-Index: 3
#2Ana Caren Cortés-Márquez (IPN: Instituto Politécnico Nacional)H-Index: 3
view all 8 authors...
Helicobacter pylori recurrence after successful eradication is an important problem. Children are particularly vulnerable to reinfection, by intrafamilial transmission which facilitates the acquisition or recombination of new genetic information by this bacterium. We investigated the evolutionary dynamics of 80 H. pylori strains isolated from two paediatric patients with recurrent infection (recrudescence and reinfection). We characterized the virulence genes vacA (s1, m1, s2, and m2), cagA, cag...
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#1Edgar Augusto Ortiz-Benítez (IPN: Instituto Politécnico Nacional)H-Index: 1
Last. José de Jesús Olivares-Trejo (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 11
view all 5 authors...
Streptococcus pneumoniae is a causal agent of otitis media, pneumonia, meningitis and severe cases of septicemia. This human pathogen infects elderly people and children with a high mortality rate of approximately one million deaths per year worldwide. Antibiotic-resistance of S. pneumoniae strains is an increasingly serious health problem; therefore, new therapies capable of combating pneumococcal infections are indispensable. The application of gold nanoparticles has emerged as an option in th...
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#1Ana Caren Cortés-Márquez (IPN: Instituto Politécnico Nacional)H-Index: 3
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Background Helicobacter pylori is a major aetiologic agent associated with gastritis. H. pylori infections increase the expression of the Toll-like receptor (TLR), which in turn modulates the expression of microRNA (miRNA)-146a and miRNA-155. The objective of this study was to compare the expression of miRNA-146a and miRNA-155 in gastric lesions of paediatric and adult patients with different pathologies and in Mongolian gerbils (Meriones unguiculatus) infected with H. pylori 26,695.
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#1Pamela Aguilar-Rodea (IPN: Instituto Politécnico Nacional)H-Index: 1
#2Gerardo Zúñiga (IPN: Instituto Politécnico Nacional)H-Index: 23
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Several microorganisms produce nosocomial infections (NIs), among which Pseudomonas aeruginosa stands out as an opportunist pathogen with the capacity to develop multiresistance to first-choice antibiotics. From 2007 to 2013, forty-six NIs produced by P. aeruginosa were detected at a pediatric tertiary care hospital in Mexico with a significant mortality rate (17.39%). All isolates (n = 58/46 patients) were characterized by evaluating their response to several antibiotics as panresistant (PDR), ...
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#1Sandra Mendoza-Elizalde (IPN: Instituto Politécnico Nacional)H-Index: 3
#2Nancy Karina Arteaga-Resendiz (IPN: Instituto Politécnico Nacional)H-Index: 1
view all 8 authors...
The bacterium Helicobacter pylori exhibits great genetic diversity, and the pathogenic roles of its virulence factors have been widely studied. However, the evolutionary dynamics of H. pylori strains during stomach colonization are not well characterized. Here, we analyzed the microevolutionary dynamics of the toxigenic strain vacAs1m1, the non-toxigenic strain vacAs2m2, and a combination of both strains in an animal model over time. Meriones unguiculatus were inoculated with the following bacte...
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#1Edgar Augusto Ortiz-Benitez (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 1
#2Mariana Carrillo-Morales (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 2
Last. José de Jesús Olivares-Trejo (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 11
view all 5 authors...
Streptococcus pneumoniae is a human pathogen whose principal virulence factor is its capsule. This structure allows the bacterium to evade the human immune system. Treatment of infections caused by this bacterium is based on antibiotics; however, the emergence of antibiotic-resistant strains makes this task increasingly difficult. Therefore, it is necessary to investigate new therapies, such as those based on gold nanoparticles, for which unfortunately the mechanisms involved have not yet been i...
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#2Alejandra Consuelo-Sánchez (Boston Children's Hospital)H-Index: 3
Last. Rafael Coria-JiménezH-Index: 4
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Background The genes jhp0940, jhp0945, jhp0947, and jhp0949 belong to the plasticity region of the Helicobacter pylori genome. Due to their prevalence in isolates from patients with gastritis, duodenal ulcer, and gastric cancer, they have been proposed as markers of gastroduodenal diseases. These genes are associated with pro-inflammatory cytokine induction through the NF-κB activation pathway. Nevertheless, the status of these genes is unknown in H. pylori isolates from children. The aim of the...
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Staphylococcus aureus is an opportunistic pathogen that colonizes human hosts and causes a wide variety of diseases. Two interacting regulatory systems called agr (accessory gene regulator) and sar (staphylococcal accessory regulator) are involved in the regulation of virulence factors. The aim of this study was to evaluate the effect of vancomycin on hld and spa gene expression during the exponential and post-exponential growth phases in multidrug resistant (MDR) S. aureus. Methods. Antibiotic ...
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#1Sandra Mendoza-Elizalde (IPN: Instituto Politécnico Nacional)H-Index: 3
#2Ana Caren Cortés-Márquez (IPN: Instituto Politécnico Nacional)H-Index: 3
view all 10 authors...
Genotypic differences in Helicobacter pylori play an important role in infection. We characterized the diversity of the cagA, cagE, babA2, and vacA genes in H. pylori strains isolated from pediatric patients and the relationship between these genes and clinical disease. Additionally, we employed the Neighbor-net algorithm to predict the behavior of the genotypes of the strains isolated from patients. Of 93 patients analyzed, 32 were positive for infection. A total of 160 H. pylori strains (five ...
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