Antonios Matsakas
Hull York Medical School
Internal medicinePhenotypeEndocrinologyMuscle hypertrophyReceptorRegeneration (biology)ChemistryGlycolysisMyocyteWild typeOxidative stressSarcopeniaMyostatinMuscular dystrophySkeletal muscleDystrophinAtrophyMyogenesisBiochemistryApolipoprotein EOxidative phosphorylationHomeostasisMedicineBiologyPlateletCell biologyEndurance training
66Publications
18H-index
1,222Citations
Publications 63
Newest
#1Francesca Solagna (UHH: University of Hamburg)
#2Caterina TezzeH-Index: 6
Last. Tobias B. Huber (UHH: University of Hamburg)H-Index: 68
view all 35 authors...
Skeletal muscle wasting is commonly associated with chronic kidney disease (CKD), resulting in increased morbidity and mortality. However, the link between kidney and muscle function remains poorly understood. Here, we took a complementary interorgan approach to investigate skeletal muscle wasting in CKD. We identified increased production and elevated blood levels of soluble pro-cachectic factors, including activin A, directly linking experimental and human CKD to skeletal muscle wasting progra...
Source
#1Joseph Barlow (Hull York Medical School)
#2Pagona Panagiota Sfyri (Hull York Medical School)H-Index: 2
Last. Antonios Matsakas (Hull York Medical School)H-Index: 18
view all 9 authors...
NEW FINDINGS What is the central question of this study? What is the impact of obesity-independent hyperlipidaemia on skeletal muscle stem cell function of ApoE-deficient (ApoE-/- ) mice? What is the main finding and its importance? Compromised muscle stem cell function accounts for the impaired muscle regeneration in hyperlipidaemic ApoE-/- mice. Importantly, impaired muscle regeneration is normalised by administration of platelet releasate. ABSTRACT Muscle satellite cells are important stem ce...
Source
#1Danielle Vaughan (University of Reading)H-Index: 2
#2Robert Mitchell (University of Reading)H-Index: 11
Last. Ketan Patel (University of Reading)H-Index: 47
view all 15 authors...
Activin/Myostatin signalling acts to induce skeletal muscle atrophy in adult mammals by inhibiting protein synthesis as well as promoting protein and organelle turnover. Numerous strategies have been successfully developed to attenuate the signalling properties of these molecules which result in augmenting muscle growth. However, these molecules, in particular Activin, play major roles in tissue homeostasis in numerous organs of the mammalian body. We have recently shown that while the attenuati...
1 CitationsSource
#1Danielle Vaughan (University of Reading)H-Index: 2
#1Antonios MatsakasH-Index: 18
Last. Ketan Patel (University of Reading)H-Index: 47
view all 15 authors...
Duchenne Muscular Dystrophy is a devastating disease caused by the absence of a functional rod-shaped cytoplasmic protein called dystrophin. Several avenues are being developed aimed to restore dystrophin expression in boys affected by this X-linked disease. However, its complete cure is likely to need combinational approaches which may include regimes aimed at restoring muscle mass. Augmenting muscle growth through the manipulation of the Myostatin/Activin signalling axis has received much atte...
1 CitationsSource
#1Michalis G. Nikolaidis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 46
#2Nikos V. Margaritelis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 15
Last. Antonios Matsakas (Hull York Medical School)H-Index: 18
view all 3 authors...
Biology is rich in claims that reactive oxygen and nitrogen species are involved in every biological process and disease. However, many quantitative aspects of redox biology remain elusive. The important quantitative parameters you need to address the feasibility of redox reactions in vivo are: rate of formation and consumption of a reactive oxygen and nitrogen species, half-life, diffusibility and membrane permeability. In the first part, we explain the basic chemical kinetics concepts and alge...
2 CitationsSource
#1Ryan Jaques (Hull York Medical School)H-Index: 1
#2Sam Xu (Hull York Medical School)H-Index: 1
Last. Antonios Matsakas (Hull York Medical School)H-Index: 18
view all 3 authors...
The transmembrane oncoprotein HER2 is encoded by ERBB2 gene and overexpressed in around 20% of invasive breast cancers. It can be specifically targeted by Trastuzumab (Herceptin(R)), a humanised IgG1 antibody. Trastuzumab has been regarded as one of the most effective therapeutic drugs targeted to HER2 positive cancers. However, there are drawbacks, notably cardiotoxicity and resistance, which have raised awareness in clinical use. Therefore, understanding the mechanism of action is vital to est...
Source
#1Danielle Vaughan (University of Reading)H-Index: 2
#2Olli Ritvos (UH: University of Helsinki)H-Index: 53
Last. Ketan Patel (University of Reading)H-Index: 47
view all 16 authors...
Numerous approaches are being developed to promote post-natal muscle growth based on attenuating Myostatin/Activin signalling for clinical uses such as the treatment neuromuscular diseases, cancer cachexia and sarcopenia. However there have been concerns about the effects of inhibiting Activin on tissues other than skeletal muscle. We intraperitoneally injected mice with the Activin ligand trap, sActRIIB, in young, adult and a progeric mouse model. Treatment at any stage in the life of the mouse...
3 CitationsSource
#1Sandrine Verpoorten (Hull York Medical School)H-Index: 3
#2Peggy Sfyri (Hull York Medical School)H-Index: 4
Last. Antonios Matsakas (Hull York Medical School)H-Index: 18
view all 8 authors...
Aim: The prevalence of obesity is a major risk factor for cardiovascular and metabolic diseases including impaired skeletal muscle regeneration. Since skeletal muscle regenerative capacity is regulated by satellite cells, we aimed to investigate whether a high-fat diet impairs satellite cell function and whether this is linked to fatty acid uptake via CD36. We also aimed to determine whether loss of CD36 impacts on muscle redox homeostasis and skeletal muscle regenerative capacity. Methods: We s...
3 CitationsSource
#1Antonios MatsakasH-Index: 18
#2Danielle VaughanH-Index: 2
Last. Tobias HuberH-Index: 11
view all 16 authors...
Numerous approaches are being developed to promote post-natal muscle growth based on attenuating Myostatin/Activin signalling for clinical uses such as the treatment neuromuscular diseases, cancer cachexia and sarcopenia. However there have been concerns about the effects of inhibiting Activin on tissues other than skeletal muscle. We intraperitoneally injected mice with the Activin ligand trap, sActRIIB, in young, adult and a progeric mouse model. Treatment at any stage in the life of the mouse...
#1Saleh Omairi (University of Reading)H-Index: 4
#2Antonios MatsakasH-Index: 18
Last. Ketan Patel (University of Reading)H-Index: 47
view all 4 authors...
Source