Uwe Schnakenberg
RWTH Aachen University
MicroelectrodeSignalAnalytical chemistryOpticsBiomedical engineeringFabricationSurface micromachiningNanotechnologyElectrodeChemistryThin filmMaterials scienceSputteringCyclic voltammetryChemical engineeringOptoelectronicsElectrochemistrySiliconDielectric spectroscopyMicrofluidics
Publications 182
#1Chen Zhou (RWTH Aachen University)H-Index: 2
#2Sebastian Bette (RWTH Aachen University)H-Index: 3
Last. Uwe Schnakenberg (RWTH Aachen University)H-Index: 34
view all 11 authors...
Abstract Stretchable microelectrodes paired with an ultra-elastic substrate can be used for electrical sensing of mechanically stretched cells and cell monolayers. Here, we present the development of a cell-stretching platform with thin-film interdigitated microelectrodes. Up to 35% cyclic stretch are feasible with a novel interlaced meander design connected to the microelectrodes and using Poly(dimethylsiloxane) (PDMS) with a Young’s modulus of 50 kPa as an ultra-elastic substrate. Reliable ele...
#1Yuan Cao (RWTH Aachen University)H-Index: 1
#2Julia Floehr (RWTH Aachen University)H-Index: 8
Last. Uwe Schnakenberg (RWTH Aachen University)H-Index: 34
view all 4 authors...
In micro-electrical-mechanical systems (MEMS), thick structures with high aspect ratios are often required. Dry film photoresist (DFR) in various thicknesses can be easily laminated and patterned using standard UV lithography. Here, we present a three-level DFR lamination process of SUEX for a microfluidic chip with embedded, vertically arranged microelectrodes for electrical impedance measurements. To trap and fix the object under test to the electrodes, an aperture is formed in the center of t...
#1Viktoria Heine (RWTH Aachen University)H-Index: 4
#2Tom Kremers (RWTH Aachen University)H-Index: 4
Last. Lothar Elling (RWTH Aachen University)H-Index: 28
view all 5 authors...
Monitoring glycosyltransferases on biosensors is of great interest for pathogen and cancer diagnostics. As a proof of concept, we here demonstrate the layer-by-layer immobilization of a multivalent neoglycoprotein (NGP) as a substrate for a bacterial fucosyltransferase (FucT) and the subsequent binding of the fucose-specific Aleuria aurantia lectin (AAL) on an electrochemical impedance spectroscopy (EIS) sensor. We report for the first time the binding kinetics of a glycosyltransferase in real-t...
#1Tom KremersH-Index: 4
#2Uwe SchnakenbergH-Index: 34
view all 3 authors...
#2Marcel Tintelott (RWTH Aachen University)H-Index: 2
#1Mohamed H. Elsafi Mabrouk (RWTH Aachen University)H-Index: 1
#2Roman Goetzke (RWTH Aachen University)H-Index: 8
Last. WagnerH-Index: 1
view all 14 authors...
Colonies of induced pluripotent stem cells (iPSCs) reveal aspects of self-organization even under culture conditions that maintain pluripotency. To investigate the dynamics of this process under spatial confinement, we used either polydimethylsiloxane (PDMS) pillars or micro-contact printing of vitronectin. There was a progressive upregulation of OCT4, E-cadherin, and NANOG within 70 {micro}m from the outer rim of iPSC colonies. Single- cell RNA-sequencing demonstrated that OCT4high subsets have...
#1Tom Kremers (RWTH Aachen University)H-Index: 4
#2Sarah Thelen (RWTH Aachen University)H-Index: 1
Last. Uwe Schnakenberg (RWTH Aachen University)H-Index: 34
view all 4 authors...
Electrowetting-on-dielectric is a decent technique to manipulate discrete volumes of liquid in form of droplets. In the last decade, electrowetting-on-dielectric systems, also called digital microfluidic systems, became more frequently used for a variety of applications because of their high flexibility and reconfigurability. Thus, one design can be adapted to different assays by only reprogramming. However, this flexibility can only be useful if the entire system is portable and easy to use. Th...
#2Daniel F. SauerH-Index: 11
Last. Ulrich SchwanebergH-Index: 59
view all 10 authors...
Incorporation of metal catalysts into protein scaffolds results in biohybrid catalysts, which have been shown to catalyze various non-natural reactions. Until recently, catalysis with biohybrid cat...
#1Tom Kremers (RWTH Aachen University)H-Index: 4
#2Nora Menzel (RWTH Aachen University)H-Index: 1
Last. Uwe Schnakenberg (RWTH Aachen University)H-Index: 34
view all 7 authors...
#1Yusuke Kubo (RWTH Aachen University)H-Index: 13
#2Bernd Hoffmann (Forschungszentrum Jülich)H-Index: 39
Last. Mersedeh Tohidnezhad (RWTH Aachen University)H-Index: 17
view all 9 authors...
Tenocytes are mechanosensitive cells intimately adapting their expression profile and hence, their phenotype to their respective mechanomilieu. The immunolocalization and expression intensity of tenogenic, anabolic and catabolic markers in tenocytes in response to in vitro mechanical loading have not been monitored by immunohistochemical staining (IHC). Thus, we investigated the association between IHC intensities, different stimulation frequencies, and tenogenic metabolism using a versatile mec...
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