Takashi Sugino
Fukushima Medical University
CancerInternal medicineRadiologyPathologyOncologyChemistryImmunologyImmunohistochemistryIn vivoPathologicalLung cancerMelanomaMetastasisSurgical oncologyAdenocarcinomaCancer researchBreast cancerMedicineCell cultureBiologyGastroenterology
Publications 148
#1Daisuke AizawaH-Index: 4
#2Takashi SuginoH-Index: 25
Last. Tadakazu ShimodaH-Index: 69
view all 9 authors...
A depth of submucosal invasion (DSI) of ≥1000 μm is an important risk factor for lymph node metastasis (LNM) in patients with submucosal invasive (pT1) colorectal cancer (CRC), according to the European Society of Gastrointestinal Endoscopy and the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines. According to the latter, if the location of the muscularis mucosae in the invasive area is not confirmed, the DSI can be measured from the surface. In these cases, a ‘remaining in...
ABSTRACT Distinguishing porocarcinoma from squamous cell carcinoma (SCC) is clinically significant; however, differential diagnosis can often be challenging. This study sought to confirm the diagnostic utility of cytokeratin 19, c-KIT, BerEP4, GATA3, and NUTM1 immunohistochemistry in distinguishing porocarcinoma from SCC. Immunohistochemical analysis of cytokeratin 19, c-KIT, BerEP4, GATA3, and NUTM1 in 14 porocarcinomas and 22 SCCs was performed; the extents and intensities of expression of the...
#1Haruna Yasui (Nagasaki University)H-Index: 4
#2Takuya KawataH-Index: 3
Last. Takashi SuginoH-Index: 25
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Invasive lobular carcinoma (ILC) of the breast is characterized by the discohesive growth of tumor cells, which is mainly associated with the complete loss of E-cadherin (E-cad) expression. However, some aberrant expression patterns of E-cad protein that are inconsistent with their morphologies have been reported in ILC. We report herein ILC cases expressing a new type of abnormal E-cad protein that lacks the N-terminal domain, but conserves the C-terminal domain on the cell membrane. Immunohist...
#1Yosuke SasakiH-Index: 4
#2Keisuke GotoH-Index: 1
Last. Yoshio KiyoharaH-Index: 19
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ABSTRACT This study aimed to identify the clinical and histopathological characteristics of secondary extramammary Paget disease (EMPD) with underlying anorectal adenocarcinoma so as to differentiate it from primary cutaneous EMPD. Seventeen and 8 cases of primary and secondary EMPD with anorectal adenocarcinoma, respectively, were retrieved from the pathology archive and the clinical and histopathological features reviewed. The tumor samples from 21 cases were totally resected specimens, wherea...
Background null Invasive gallbladder carcinoma generally presents nodular-sclerosing growth. Recently, "polypoid invasive carcinoma (PICA)" showing grossly visible polypoid neoplasm and histologically invasive carcinoma with no adenomatous components was proposed as a neoplastic polyp of the gallbladder. null Methods null We herein report 5 cases of PICA collected from 49 cases of invasive gallbladder carcinoma in comparison with another polypoid preinvasive neoplasm of gallbladder, intracholecy...
#1Shota OmoriH-Index: 12
#2Koji MuramatsuH-Index: 7
Last. Toshiaki TakahashiH-Index: 47
view all 16 authors...
#1Ryota KondouH-Index: 10
#2Yasuto AkiyamaH-Index: 23
Last. Kenichi UrakamiH-Index: 16
view all 34 authors...
#1Kenichiro Furukawa (Keio: Keio University)H-Index: 4
#2Keiichi HatakeyamaH-Index: 11
Last. Keiichi FujiyaH-Index: 8
view all 17 authors...
Gastric cancer (GC) has been classified based on molecular profiling like The Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG), and attempts have been made to establish therapeutic strategies based on these classifications. However, it is difficult to predict the survival according to these classifications especially in radically resected patients. We aimed to establish a new molecular classification of GC which predicts the survival in patients undergoing radical gastrectomy. T...
#1Junichiro WatanabeH-Index: 8
#2Shogo NakamotoH-Index: 2
Last. Takashi SuginoH-Index: 25
view all 3 authors...
BACKGROUND The real-world outcomes of patients with advanced invasive lobular carcinoma (ILC) of the breast are unclear because of its rarity. PATIENTS AND METHODS We identified 435 patients with estrogen receptor-positive (ER+), HER2-negative (HER2-) advanced breast cancer treated at our Institute between 2002 and 2019, and analyzed their outcomes retrospectively. RESULTS We identified 29 patients with advanced ILC. At presentation, they had a lower rate of lung metastasis (p=0.0053) but a high...
EMI Domain Containing 1 (EMID1) was identified as a potential candidate metastasis-promoting gene. We sought to clarify the molecular function of EMID1 and the protein expression. Overexpression and knockdown studies using mouse tumor cell lines identified two novel functions of EMID1: intracellular signaling involving enhancement of cell growth via cell cycle promotion and suppression of cell motility, and inhibition of cell-matrix adhesion by extracellularly secreted EMID1. EMID1 deposited on ...
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