Masaki Fujimura
Kanazawa University
Internal medicineRadiologyEndocrinologySurgeryPathologyOncologyImmunologyAsthmaBronchial hyperresponsivenessLung cancerInhalationChronic coughLungBronchoalveolar lavageBronchoconstrictionMethacholineAnesthesiaMedicineGastroenterologyPharmacology
583Publications
53H-index
7,313Citations
Publications 582
Newest
#1Atsushi OkitaH-Index: 2
#2Masaki FujimuraH-Index: 53
Last. Kimitsuka KumanoH-Index: 3
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#1Hironobu Sunadome (Kyoto University)H-Index: 5
#2Hisako Matsumoto (Kyoto University)H-Index: 48
Last. Toyohiro Hirai (Kyoto University)H-Index: 37
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#1Johsuke Hara (Kanazawa University)H-Index: 12
#2Masaki FujimuraH-Index: 53
Last. Noriyuki Ohkura (Kanazawa University)H-Index: 15
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BackgroundWe previously elucidated the fundamental pathophysiological features of various aetiologies of chronic cough, such as cough variant asthma, atopic cough, and sinobronchial syndrome. We also established a pathophysiological diagnostic procedure for aetiology identification. In this study, we aimed to disclose the aetiologies of chronic cough using the pathophysiological diagnostic procedure and to determine the outcomes of treatment administered on the basis of aetiology. Patients and M...
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The case subject was a 19-year-old exchange student from Thailand who had undergone tuberculosis (TB) treatment twice. Upon observing a shadow in the right upper lung, the patient was referred for examination; however, acid-fast bacteria test results were negative. Furthermore, high levels of total IgE and anti-aspergillus IgE and IgG antibodies were found. Bronchoscopy revealed inflammation with stenosis in the right superior lobar bronchus, and there was an outflow of yellow viscous sputum upo...
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#1Noriyuki Ohkura (Kanazawa University)H-Index: 15
#2Masaki FujimuraH-Index: 53
Last. Kazuo Kasahara (Kanazawa University)H-Index: 28
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Abstract Background Cough variant asthma (CVA) is the most common cause of chronic cough and responds well to bronchodilator therapy. Previous studies on methacholine -induced cough have shown that heightened cough response due to bronchoconstriction is a feature of CVA. The aim of this study was to assess Mch-induced cough as an indicator of bronchodilator-responsive cough (BRC). Methods This was a single-center retrospective study of prolonged/chronic cough cases who underwent evaluation via s...
1 CitationsSource
#1Kenta Yamamura (Kanazawa University)H-Index: 3
#2Johsuke Hara (Kanazawa University)H-Index: 12
Last. Kazuo Kasahara (Kanazawa University)H-Index: 28
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Abstract Background Cough variant asthma (CVA) is recognized as a precursor of bronchial asthma (BA). However, the cough response to bronchoconstriction differs between these similar diseases. Repeated bronchoconstriction and the resulting imbalance of endogenous lipid mediators may impact the cough response. Methods We investigated the influence of repeated bronchoconstriction on the cough response to bronchoconstriction using naive guinea pigs. Bronchoconstriction was induced for 3 consecutive...
1 CitationsSource
#1Yoshihisa Ishiura (Kansai Medical University)H-Index: 1
#1Yoshihisa Ishiura (Kansai Medical University)H-Index: 17
Last. Shosaku Nomura (Kansai Medical University)H-Index: 52
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Purpose: Asthma-chronic obstructive pulmonary disease overlap (ACO), characterized by airway limitation, is an important condition with high incidence and mortality. Although some guidelines recommend triple therapy with inhaled corticosteroids/long-acting muscarinic antagonists/long-acting beta2 agonists, this treatment approach is based on the extrapolation of data from studies of asthma or chronic obstructive pulmonary disease (COPD) alone. Methods: A 12-week, randomized, open-label cross-ove...
3 CitationsSource
#1Yoshihisa Ishiura (Kansai Medical University)H-Index: 17
#2Masaki Fujimura (Kanazawa University)H-Index: 53
Last. Shosaku Nomura (Kansai Medical University)H-Index: 52
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OBJECTIVE: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is of increasing interest because ACO patients have significantly worse outcomes, leading to greater social and economic burdens compared with asthma or COPD alone. Some guidelines for ACO recommend triple therapy with inhaled corticosteroids, long-acting β2 agonists, and long-acting muscarinic antagonists. However, this approach is based on extrapolating data from patients with asthma or COPD alone. Therapeutic studies...
9 CitationsSource
#1Haruhiko OgawaH-Index: 17
#2Kazuya Tone (Jikei University School of Medicine)H-Index: 5
Last. Koichi Makimura (Teikyo University)H-Index: 36
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1 CitationsSource
#1Tamami Sakai (Kanazawa University)H-Index: 3
#2Johsuke Hara (Kanazawa University)H-Index: 12
Last. Shinji Nakao (Kanazawa University)H-Index: 59
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AbstractPurpose/Aim of the study: Methacholine chloride (MCh) inhalation causes bronchoconstriction and cough. Following MCh-induced bronchoconstriction, metabolic products of prostaglandin I2 (PGI...
1 CitationsSource