Fabio Falaschi
University of Pisa
Internal medicineRadiologySurgeryMagnetic resonance imagingPerfusionFEV1/FVC ratioRespiratory diseaseLung cancerLung cancer screeningHigh-resolution computed tomographyInterstitial lung diseaseCholangiographyLungMr imagingNuclear medicineRadiographyComputed tomographyMedicinePulmonary function testing
Publications 84
#1Luna Gargani (National Research Council)H-Index: 44
#2Cosimo Bruni (UniFI: University of Florence)H-Index: 17
Last. Marco Matucci-Cerinic (UniFI: University of Florence)H-Index: 95
view all 14 authors...
Interstitial lung disease (ILD) is frequent and highly disabling in systemic sclerosis (SSc). Magnetic resonance imaging (MRI) is not routinely used to evaluate the lung, due to poorer spatial resolution compared to high-resolution computed tomography (HRCT). We aimed to compare lung MRI signal with HRCT and evaluate the role of MRI in predicting ILD progression. Thirty SSc patients underwent lung MRI and HRCT. STIR and T1 mapping sequences were acquired before and after gadolinium injection. Pa...
2 CitationsSource
#1Eugenio PaciH-Index: 55
#2Donella PulitiH-Index: 22
Last. Marco ZappaH-Index: 51
view all 10 authors...
ObjectivesOverdiagnosis in low-dose computed tomography randomized screening trials varies from 0 to 67%. The National Lung Screening Trial (extended follow-up) and ITALUNG (Italian Lung Cancer Scr...
#1Luna Gargani (National Research Council)H-Index: 44
#2Cosimo Bruni (UniFI: University of Florence)H-Index: 17
Last. Marco Matucci-Cerinic (UniFI: University of Florence)H-Index: 95
view all 20 authors...
Abstract Background A high percentage of systemic sclerosis (SSc) patients develop interstitial lung disease (ILD) during the disease course. Recent data have shown that lung ultrasound (LUS) can assess ILD by the evaluation of B-lines, the sonographic sign of pulmonary interstitial involvement. Our aim was to establish the prognostic value of B-lines in a large number of SSc patients. Methods A total of 396 consecutive SSc patients, enrolled at three Rheumatology Departments, underwent a compre...
15 CitationsSource
BACKGROUND: Changes in smoking habits and predictors of smoking cessation were examined in the randomized ITALUNG lung cancer screening trial. METHODS: In three centers, eligible smokers or ex-smokers (55-69 years, ≥ 20 pack-years in the last 10 years) were randomised to receive annual invitation for low-dose computed tomography for 4 years or usual care. At invitation, subjects received written information for a free smoking cessation program. Quitting outcome was assessed at year 4. RESULTS: A...
9 CitationsSource
Background: Interstitial lung disease (ILD), is common in patients with idiopathic inflammatory myopathies (IIM) and strongly impact on patients’ morbidity and mortality. Patients with anti-aminoacyl-transfer RNA-synthetases (anti-ARS) antibodies are associated with an increased risk of ILD. Objectives: Defining the radiological characteristics of IIM patients, with special focus on serological groups, through qualitative, semiquantitative and quantitative analysis of lung CT. Methods: This was ...
#1Chiara RomeiH-Index: 6
#2Laura TavantiH-Index: 7
Last. Fabio FalaschiH-Index: 24
view all 9 authors...
Abstract Purpose To investigate the role of a quantitative analysis software (CALIPER) in identifying HRCT thresholds predicting IPF patients’ survival and lung function decline and its role in detecting changes of HRCT abnormalities related to treatment and their correlation with Forced Vital Capacity (FVC). Methods This retrospective study included 105 patients with a multidisciplinary diagnosis of IPF for whom one HRCT at baseline and concomitant FVC were available. HRCTs were evaluated with ...
10 CitationsSource
#1Donella PulitiH-Index: 22
#2Mario Mascalchi (UniFI: University of Florence)H-Index: 59
Last. Marco ZappaH-Index: 51
view all 15 authors...
Abstract Objectives In the ITALUNG lung cancer screening trial after 9.3 years of follow-up we observed an unexpected significant decrease of cardiovascular (CV) mortality in subjects invited for low-dose CT (LDCT) screening as compared to controls undergoing usual care. Herein we extended the mortality follow-up and analyzed the potential factors underlying such a decrease. Materials and methods The following factors were assessed in screenes and controls: burden of CV disease at baseline, chan...
4 CitationsSource
: We investigated the potential role of extracellular vesicles as biomarkers in interstitial lung diseases. Endothelial derived extracellular vesicles were enumerated in 14 consecutive patients with usual interstitial pneumonia or possible usual interstitial pneumonia, and 18 normal controls by flow cytometry. The number of endothelial derived extracellular vesicles was significantly greater in patients compared to controls [160 (73) vs. 85 (31) events/min respectively; median (interquartile ran...
3 Citations
#2Piero BoraschiH-Index: 22
Last. Davide Caramella (UniPi: University of Pisa)H-Index: 36
view all 8 authors...
Abstract Purpose To assess the usefulness of qualitative and quantitative analyses of pancreatic focal diseases by using the dynamic contrast-enhanced Differential Subsampling with Cartesian Ordering (DISCO) sequence at 3 T MR device. Materials and methods Ten patients without pancreatic diseases and twenty-five patients with pathologically confirmed pancreatic focal disease (ductal adenocarcinoma, n = 14; endocrine tumour, n = 8; focal chronic pancreatitis, n = 3), underwent MRI by 3 T-device. ...
1 CitationsSource
#1G. Corsi (UniPi: University of Pisa)
#2Chiara Romei (UniPi: University of Pisa)H-Index: 6
Last. Alessandro Celi (UniPi: University of Pisa)H-Index: 24
view all 6 authors...