Michael S. Pepper
University of Pretoria
Endothelial stem cellEndocrinologyPathologyVascular endothelial growth factor AMolecular biologyStromal cellLymphatic systemMesenchymal stem cellImmunologyLymphangiogenesisEndotheliumVascular endothelial growth factorBasic fibroblast growth factorNeovascularizationAngiogenesisStem cellCancer researchMedicineBiologyCell biology
Publications 301
#1Elize Wolmarans (University of Pretoria)H-Index: 3
#2Juanita Mellet (University of Pretoria)H-Index: 3
Last. Michael S. Pepper (University of Pretoria)H-Index: 73
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The potential for human adipose-derived stromal cells (hASCs) to be used as a therapeutic product is being assessed in multiple clinical trials. However, much is still to be learned about these cells before they can be used with confidence in the clinical setting. An inherent characteristic of hASCs that is not well understood is their heterogeneity. The aim of this exploratory study was to characterize the heterogeneity of freshly isolated hASCs after two population doublings (P2) using single-...
#1Ciara Staunton (UCT: University of Cape Town)H-Index: 11
#2Rachel Adams (Human Sciences Research Council)H-Index: 1
Last. Michèle Ramsay (University of the Witwatersrand)H-Index: 38
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Globally, there has been a move toward ‘open science’ that includes the sharing of health data for research. The importance of data sharing for research is generally acknowledged, but this must only be done with legal and ethical procedures and protections in place. The use and sharing of health data for research in South Africa has changed with the coming into force of the Protection of Personal Information Act (POPIA). POPIA should ensure greater transparency and accountability in the use of p...
#1Ignatius M. Viljoen (South African Medical Research Council)H-Index: 1
#2Candice Laverne Hendricks (South African Medical Research Council)
Last. Michael S. Pepper (South African Medical Research Council)H-Index: 73
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Abstract The South African population is highly diverse, both ethnically and genetically. This diversity is particularly true for the African ancestry and various mixed ancestry population groups. These groups are under-represented in national and international bone marrow and peripheral blood donor registries, making it challenging to identify HLA-matched and mismatched unrelated donors when patients from these groups require allogeneic hematopoietic stem and progenitor cell transplantation. In...
#1Kimberly Thando Peta (University of Pretoria)
#2Melvin A Ambele (University of Pretoria)H-Index: 5
Last. Michael S. Pepper (University of Pretoria)H-Index: 73
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Tumours are characterized by a state of chronic inflammation and are regarded as wounds that never heal. Mesenchymal stromal/stem cells (MSCs) are being considered as a possible treatment option. While MSCs can regulate the immune system, migrate to sites of inflammation, and are naturally immune-privileged, there have been contradictory reports on the role of these cells in the tumour microenvironment (TME). Some studies have suggested that MSCs promote tumourigenesis while others have suggeste...
#1Don A. Cowan (University of Pretoria)H-Index: 52
#2Stephanie G. Burton (University of Pretoria)H-Index: 26
Last. Michael S. Pepper (South African Medical Research Council)H-Index: 73
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The current SARS-CoV-2 pandemic has brought a number of major global clinical, sociological and economic issues into sharp focus. We address some of these issues, focusing on short-term factors such as virus mutations and vaccine efficacy, and also considering the longer-term implications of the current pandemic. We discuss societal responses to the presence of a pathogen that will probably remain in circulation for decades or longer, and to future new emergent viruses.
#2Wolf-Dieter Schubert (University of Pretoria)H-Index: 33
Last. Xue Zhong LiuH-Index: 35
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MYO7A gene encodes unconventional myosin VIIA, which, when mutated, causes a phenotypic spectrum ranging from recessive hearing loss DFNB2 to deaf-blindness, Usher Type 1B (USH1B). MYO7A mutations are reported in nine DFNB2 families to date, none from sub-Saharan Africa.In DNA, from a cohort of 94 individuals representing 92 families from the Limpopo province of South Africa, eight MYO7A variations were detected among 10 individuals. Family studies identified homozygous and compound heterozygous...
#1A.E. Mercier (University of Pretoria)H-Index: 2
#2Renaud Prudent (UGA: University of Grenoble)H-Index: 2
Last. Anna Margaretha Joubert (University of Pretoria)H-Index: 11
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The search for novel anti-cancer compounds which can circumvent chemotherapeutic drug resistance and limit systemic toxicity remains a priority. 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)15-tetraene-3-ol-17one (ESE-15-one) and 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16) are sulphamoylated 2-methoxyestradiol (2-ME) analogues designed by our research team. Although their cytotoxicity has been demonstrated in vitro, the temporal and mechanistic responses of the initiated intracellular ev...
#1Juanita Mellet (University of Pretoria)H-Index: 3
#2Michael S. Pepper (University of Pretoria)H-Index: 73
As of 8 January 2021, there were 86,749,940 confirmed coronavirus disease 2019 (COVID-19) cases and 1,890,342 COVID-19-related deaths worldwide, as reported by the World Health Organization (WHO). In order to address the COVID-19 pandemic by limiting transmission, an intense global effort is underway to develop a vaccine against SARS-CoV-2. The development of a safe and effective vaccine usually requires several years of pre-clinical and clinical stages of evaluation and requires strict regulato...
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