Deepak Madhavan
University of Nebraska Medical Center
Internal medicineEndocrinologyHippocampal formationArtificial intelligencePsychologyNeuroscienceIctalPattern recognitionPediatricsImmunologyEpilepsyKetogenic dietEpilepsy surgeryImmunoglobulin GFulminantHippocampusPopulationCD40 Ligand DeficiencyIntravenous Immunoglobulin TherapyDrug Resistant EpilepsyCognitive declineComputer scienceArtificial neural networkElectroencephalographyMagnetoencephalographyMedicineEncephalitisBiologyImmune system
Publications 18
#1Alicia Johnson (NU: University of Nebraska–Lincoln)
#2Ryan Grove (NU: University of Nebraska–Lincoln)H-Index: 8
Last. Jiri Adamec (NU: University of Nebraska–Lincoln)H-Index: 11
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Approximately 1% of the world’s population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists for MRE includes the ketogenic diet, a high-fat, low-carbohydrate diet. Despite the KD’s success in seizure attenuation, it has a few risks and its mechanisms remain poorly understood. The KD has been shown to improve metabolism and m...
1 CitationsSource
#1Ryan Grove (NU: University of Nebraska–Lincoln)H-Index: 8
#2Deepak Madhavan (UNMC: University of Nebraska Medical Center)H-Index: 11
Last. Jiri Adamec (NU: University of Nebraska–Lincoln)H-Index: 11
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Abstract Epilepsy is a disorder that affects around 1% of the population. Approximately one third of patients do not respond to anti-convulsant drugs treatment. To understand the underlying biological processes involved in drug resistant epilepsy (DRE), a combination of proteomics strategies was used to compare molecular differences and enzymatic activities in tissue implicated in seizure onset to tissue with no abnormal activity within patients. Label free quantitation identified 17 proteins wi...
#1Marc J. Schniederjans (NU: University of Nebraska–Lincoln)H-Index: 30
#2Deepak Madhavan (UNMC: University of Nebraska Medical Center)H-Index: 11
Last. Dara G. Schniederjans (URI: University of Rhode Island)H-Index: 12
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PURPOSE: Data on the timeliness of emergent medication delivery for nonconvulsive status epilepticus (NCSE) are currently lacking. METHODS: Retrospective chart reviews (between 2015 and 2018) and analyses of all patients with NCSE were performed at the University of Nebraska Medical Center, a level 4 epilepsy center, to determine the latencies to order and administration of the first, second, and third antiepileptic drugs (AEDs). Recurrent NCSE cases were considered independently and classified ...
#1Lawrence J. Hirsch (Yale University)H-Index: 74
#2Emily A. MirroH-Index: 7
Last. Martha J. Morrell (Stanford University)H-Index: 59
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OBJECTIVE: To describe seizure outcomes in patients with medically refractory epilepsy who had evidence of bilateral mesial temporal lobe (MTL) seizure onsets and underwent MTL resection based on chronic ambulatory intracranial EEG (ICEEG) data from a direct brain-responsive neurostimulator (RNS) system. METHODS: We retrospectively identified all patients at 17 epilepsy centers with MTL epilepsy who were treated with the RNS System using bilateral MTL leads, and in whom an MTL resection was subs...
16 CitationsSource
Last. Olga TaraschenkoH-Index: 4
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Last. Deepak MadhavanH-Index: 11
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#1Ted J. Warren (Creighton University)H-Index: 4
#2Timothy A. Simeone (Creighton University)H-Index: 19
Last. Kristina A. Simeone (Creighton University)H-Index: 14
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Abstract Objective Adenosine participates in maintaining the excitatory/inhibitory balance in neuronal circuits. Studies indicate that adenosine levels in the cortex and hippocampus increase and exert sleep pressure in sleep-deprived and control animals, whereas in epilepsy reduced adenosine tone promotes hyperexcitability. To date, the role of adenosine in pathological conditions that result in both seizures and sleep disorders is unknown. Here, we determined adenosine tone in sleep and seizure...
7 CitationsSource
#1Olga Taraschenko (UNMC: University of Nebraska Medical Center)H-Index: 4
#2Swetha Pedavally (UNMC: University of Nebraska Medical Center)H-Index: 3
Last. Deepak Madhavan (UNMC: University of Nebraska Medical Center)H-Index: 11
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Abstract Corpus callosotomy (CC) is used in patients with drug-resistant seizures who are not candidates for excisional surgery and failed neurostimulation. We examined ictal scalp and intracranial electroencephalogram (iEEG) recordings in 16 patients being evaluated for anterior CC alone or CC in combination with focal resection, to determine the role of the iEEG in predicting postoperative seizure outcomes. In our cohort, CC improved generalized atonic seizures and focal seizures with impaired...
2 CitationsSource
#1Deepak Madhavan (UNMC: University of Nebraska Medical Center)H-Index: 11
#2Marc J. Schniederjans (College of Business Administration)H-Index: 30
Last. Dara G. Schniederjans (College of Business Administration)H-Index: 12
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The University of Nebraska Medical Center (UNMC) comprehensive epilepsy program has faced challenges accompanying the growth of the centre focused on optimising patient throughput and minimising wait times. Wait times in particular have been a problem due to deficiencies in infrastructural organisation and capacity for diagnostic testing. This paper focuses on the outcomes of the implementation of lean management in the UNMC comprehensive epilepsy program. Performance comparisons on wait times f...