Ismail Labgaa
Icahn School of Medicine at Mount Sinai
CancerInternal medicineRadiologySurgeryPathologyOncologyResectionSerum albuminRetrospective cohort studyLiver cancerHepatectomyCarcinomaHepatocellular carcinomaAbdominal surgeryLiver surgeryIn patientPerioperativeCancer researchMedicineCohortBiomarker (medicine)ComplicationBiologyGastroenterology
Publications 74
#1Amanda J. Craig (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 8
#2Teresa Garcia-Lezana (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 7
Last. Gabriela Hernandez-Meza (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 6
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Cancer testis antigens (CTAs) are an extensive gene family with a unique expression pattern restricted to germ cells, but aberrantly reactivated in cancer tissues. Studies indicate that the expression (or re-expression) of CTAs within the MAGE-A family is common in hepatocellular carcinoma (HCC). However, no systematic characterization has yet been reported. The aim of this study is to perform a comprehensive profile of CTA de-regulation in HCC and experimentally evaluate the role of MAGEA3 as a...
#1Kosuke Kobayashi (UNIL: University of Lausanne)H-Index: 5
#2Yoshikuni Kawaguchi (UTokyo: University of Tokyo)H-Index: 19
Last. Nermin Halkic (UNIL: University of Lausanne)H-Index: 11
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BACKGROUND The present study aimed to assess performance of the three-level complexity classification which stratified liver resection procedures into three complexity grades (grade I, low; grade II, intermediate; grade III, high complexity) and to evaluate whether the enhanced recovery after surgery (ERAS) protocol improves postoperative outcomes for each complexity grade. STUDY DESIGN Consecutive patients undergoing open liver resection (OLR) and laparoscopic liver resection (LLR) at Lausanne ...
Some hepato-biliary cancers require major liver resections. Post hepatectomy liver failure is a complication that occurs when the remnant liver cannot maintain its synthetic and excretory functions. To overcome this issue, portal vein embolization has been developed to induce future remnant liver hypertrophy preoperatively. However, up to 20% of patients cannot proceed to the hepatectomy due to insufficient hypertrophy or tumor progression in the interval between the embolization and the planned...
#5G. NappoH-Index: 3
#9M.G.H. BesselinkH-Index: 5
Last. M.G. BesselinkH-Index: 2
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#2Miguel Torres-Martin (University of Barcelona)
#2Miguel Torres-Martin (University of Barcelona)H-Index: 2
#1S. Gonvers (UNIL: University of Lausanne)
#2Jonas Jurt (UNIL: University of Lausanne)H-Index: 6
Last. Ismail Labgaa (UNIL: University of Lausanne)H-Index: 15
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BACKGROUND The clinical and economic impacts of enhanced recovery after surgery (ERAS) programmes have been demonstrated extensively. Whether ERAS protocols also have a biological effect remains unclear. This study aimed to investigate the biological impact of an ERAS programme in patients undergoing liver surgery. METHODS A retrospective analysis of patients undergoing liver surgery (2010-2018) was undertaken. Patients operated before and after ERAS implementation in 2013 were compared. Surroga...
#1Gaëtan-Romain Joliat (UNIL: University of Lausanne)H-Index: 12
#2Pierre Allemann (UNIL: University of Lausanne)H-Index: 20
Last. Markus Schäfer (UNIL: University of Lausanne)H-Index: 40
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Abstract Background Resection margin status and lymph node (LN) involvement are known prognostic factors for patients who undergo pancreatoduodenectomy for pancreatic ductal adenocarcinoma (PDAC). This study aimed to compare overall survival (OS) and disease-free survival (DFS) by resection margin status in patients with PDAC and LN involvement. Methods A retrospective international multicentric study was performed including four Western centers. Multivariable Cox analysis was performed to ident...
#1Ismail Labgaa (UNIL: University of Lausanne)H-Index: 15
#2Augusto Villanueva (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 63
Last. Emmanuel Melloul (UNIL: University of Lausanne)H-Index: 4
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Showing a steadily increasing cancer-related mortality, the epidemiological evolution of hepatocellular carcinoma (HCC) is concerning. Numerous strategies have attempted to prognosticate HCC but their performance is modest; this is partially due to the heterogeneous biology of this cancer. Current clinical guidelines endorse classifications and scores that use clinical variables, such as the Barcelona Clinic Liver Cancer (BCLC) classification. These algorithms are unlikely to fully recapitulate ...
1 CitationsSource
#1Ismail Labgaa (UNIL: University of Lausanne)H-Index: 15
#2Styliani Mantziari (UNIL: University of Lausanne)H-Index: 8
Last. Markus Schäfer (UNIL: University of Lausanne)H-Index: 40
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BACKGROUND AND OBJECTIVES Serum albumin perioperative decrease (∆Alb) may reflect the magnitude of the physiological stress induced by surgery. Studies highlighted its value to predict adverse postoperative outcomes, but data in esophageal surgery are scant. This study aimed to investigate the role of ∆Alb to predict major complications after esophagectomy for cancer. METHODS Multicenter retrospective study conducted in five high-volume centers, including consecutive patients undergoing an esoph...
#1Johann von Felden (UHH: University of Hamburg)H-Index: 15
#2Amanda J. Craig (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 8
Last. Augusto Villanueva (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 63
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Little is known about the mutational landscape of advanced hepatocellular carcinoma (HCC), and predictive biomarkers of response to systemic therapies are lacking. We aimed to describe the mutational landscape of advanced HCC and to identify predictors of primary resistance to systemic therapies using circulating tumor DNA (ctDNA). We prospectively enrolled 121 patients between October 2015 and January 2019. We performed targeted ultra-deep sequencing of 25 genes and Digital Droplet PCR of TERT ...
4 CitationsSource