Hanibal Hani Adamo
Umeå University
CancerInternal medicineDownregulation and upregulationPathologyOncologyGene expressionGene expression profilingExtracellular matrixTumor M2-PKLysyl oxidaseImmunohistochemistryProstateMSMBMetastasisHeme oxygenaseMacrophageMast cellProstate cancerLymph nodeAdenocarcinomaAminopropionitrileMicroseminoprotein betaRat ProstateProstate tumorsDiagnostic biomarkerDiagnostic methodsNormal tissueBenign prostateTumor gradeCancer researchEpitheliumAndrogen receptorCell growthMedicineCell cultureBiologyPCA3Cancer cell
Publications 7
#1Hanibal Hani Adamo (Umeå University)H-Index: 5
#2Peter Hammarsten (Umeå University)H-Index: 16
Last. Anders Bergh (Umeå University)H-Index: 74
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Implantation of rat prostate cancer cells into the normal rat prostate results in tumor-stimulating adaptations in the tumor-bearing organ. Similar changes are seen in prostate cancer patients and ...
3 CitationsSource
#2Helena Järemo (Umeå University)H-Index: 2
Last. Anders BerghH-Index: 74
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Background: Microseminoprotein-beta (MSMB) is a major secretory product from prostate epithelial cells. MSMB synthesis is decreased in prostate tumors in relation to tumor grade. MSMB levels are al ...
7 CitationsSource
#1Sofia Halin Bergström (Umeå University)H-Index: 8
#2Maria Nilsson (Umeå University)H-Index: 5
Last. Anders Bergh (Umeå University)H-Index: 74
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Aggressive tumors induce tumor-supporting changes in the benign parts of the prostate. One factor that has increased expression outside prostate tumors is hemoxygenase-1 (HO-1). To investigate HO-1 expression in more detail, we analyzed samples of tumor tissue and peritumoral normal prostate tissue from rats carrying cancers with different metastatic capacity, and human prostate cancer tissue samples from primary tumors and bone metastases. In rat prostate tumor samples, immunohistochemistry and...
10 CitationsSource
#1Maria Nilsson (Umeå University)H-Index: 5
#2Hanibal Hani Adamo (Umeå University)H-Index: 5
Last. Sofia Halin Bergström (Umeå University)H-Index: 8
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Lysyl oxidase (LOX) and LOX-like (LOXL) enzymes are key players in extracellular matrix deposition and maturation. LOX promote tumour progression and metastasis, but it may also have tumour-inhibit ...
32 CitationsSource
#1Hanibal Hani AdamoH-Index: 5
Background: Prostate cancer is the most common cancer in Sweden. Due its highly variable behavior, multifocal nature, and insufficient diagnostic methods, prostate cancer is difficult to diagnose a ...
#1Hanibal Hani Adamo (Umeå University)H-Index: 5
#2Kerstin Strömvall (Umeå University)H-Index: 5
Last. Anders Bergh (Umeå University)H-Index: 74
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In order to grow, tumors need to induce supportive alterations in the tumor-bearing organ, by us named tumor instructed normal tissue (TINT) changes. We now examined if the nature and magnitude of these responses were related to tumor size and aggressiveness. Three different Dunning rat prostate tumor cells were implanted into the prostate of immune-competent rats; 1) fast growing and metastatic MatLyLu tumor cells 2) fast growing and poorly metastatic AT-1 tumor cells, and 3) slow growing and n...
12 CitationsSource
#1Hanibal Hani Adamo (Umeå University)H-Index: 5
#2Sofia Halin Bergström (Umeå University)H-Index: 8
Last. Anders Bergh (Umeå University)H-Index: 74
view all 3 authors...
Implantation of rat prostate cancer cells into the normal rat prostate results in tumor-stimulating changes in the tumor-bearing organ, for example growth of the vasculature, an altered extracellular matrix, and influx of inflammatory cells. To investigate this response further, we compared prostate morphology and the gene expression profile of tumor-bearing normal rat prostate tissue (termed tumor-instructed/indicating normal tissue (TINT)) with that of prostate tissue from controls. Dunning ra...
10 CitationsSource