Murali M. Yallapu
University of Texas at Austin
CancerBiophysicsInternal medicineNanotechnologyChemistryApoptosisMaterials scienceIn vitroImmunologyIn vivoCurcuminPancaMetastasisDrug deliveryDrugProstate cancerPancreatic cancerCell cycleCancer researchCell growthMedicineBiologyCancer cellPharmacology
Publications 163
#1Andrew E. Massey (NIH: National Institutes of Health)
#1Andrew E. Massey (NIH: National Institutes of Health)H-Index: 5
Last. Bilal Bin Hafeez (University of Texas at Austin)H-Index: 29
view all 10 authors...
Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implication...
#1Kaining ZhiH-Index: 3
#2Babatunde RajiH-Index: 2
Last. Santosh KumarH-Index: 36
view all 12 authors...
The blood–brain barrier (BBB) is a natural obstacle for drug delivery into the human brain, hindering treatment of central nervous system (CNS) disorders such as acute ischemic stroke, brain tumors, and human immunodeficiency virus (HIV)-1-associated neurocognitive disorders. Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible polymer that is used in Food and Drug Administration (FDA)-approved pharmaceutical products and medical devices. PLGA nanoparticles (NPs) have been reported to improve...
2 CitationsSource
#1Deepak S. ChauhanH-Index: 10
#1Deepak S. Chauhan (University of Texas at Austin)
Last. Murali M. YallapuH-Index: 34
view all 9 authors...
Novel strategies modulating the immune system yielded enhanced anticancer responses and improved cancer survival. Nevertheless, the success rate of immunotherapy in cancer treatment has been below expectation(s) due to unpredictable efficacy and off-target effects from systemic dosing of immunotherapeutic. As a result, there is an unmet clinical need for improving conventional immunotherapy. Nanotechnology offers several new strategies, multimodality, and multiplex biological targeting advantage...
#1Pallabita Chowdhury (UTHSC: University of Tennessee Health Science Center)H-Index: 12
#2Upasana Ghosh (RU: Rutgers University)
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
view all 6 authors...
The management of aggressive breast cancer, particularly, triple negative breast cancer (TNBC) remains a formidable challenge, despite treatment advancement. Although newer therapies such as atezolizumab, olaparib, and sacituzumab can tackle the breast cancer prognosis and/or progression, but achieved limited survival benefit(s). The current research efforts are aimed to develop and implement strategies for improved bioavailability, targetability, reduce systemic toxicity, and enhance therapeuti...
#1Benilde Adriano (University of Texas at Austin)H-Index: 1
#2Nycol M. Cotto (University of Texas at Austin)H-Index: 1
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
view all 6 authors...
Abstract Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles. Exosomes have proven to be excellent nanocarriers for carrying lipids, proteins, mRNAs, non-coding RNAs, and DNAs, and disseminating long-distance intercellular communications in various biological processes. Among various cell-line or biological fluid derived exosomes, milk exosomes are abundant in nature and exhibit many nanocarrier characte...
7 CitationsSource
#1Neeraj Chauhan (University of Texas at Austin)H-Index: 24
#1Neeraj Chauhan (University of Texas at Austin)H-Index: 10
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
view all 4 authors...
The novel coronavirus (CoV) disease 2019 (COVID-19) is a viral infection that causes severe acute respiratory syndrome (SARS). It is believed that early reports of COVID-19 cases were noticed in De...
10 CitationsSource
#1Hossein Rahimi (Zanjan University of Medical Sciences)H-Index: 2
#2Marziyeh Salehiabar (Tabriz University of Medical Sciences)H-Index: 10
Last. João Conde (NOVA: Universidade Nova de Lisboa)H-Index: 33
view all 13 authors...
The emergence of the new coronavirus 2019 (COVID-19) was first seen in December 2019, which has spread rapidly and become a global pandemic. The number of cases of COVID-19 and its associated mortality have raised serious concerns worldwide. Early diagnosis of viral infection undoubtedly allows rapid intervention, disease management, and substantial control of the rapid spread of the disease. Currently, the standard approach for COVID-19 diagnosis globally is the RT-qPCR test; however, the limit...
12 CitationsSource
#1Mohammed Sikander (University of Texas at Austin)H-Index: 7
#1Mohammed Sikander (University of Texas at Austin)
Last. Meena Jaggi (University of Texas at Austin)H-Index: 1
view all 9 authors...
COVID-19 is known as one of the deadliest pandemics of the century. The rapid spread of this deadly virus at incredible speed has stunned the planet and poses a challenge to global scientific and medical communities. Patients with COVID-19 are at an increased risk of co-morbidities associated with liver dysfunction and injury. Moreover, hepatotoxicity induced by antiviral therapy is gaining importance and is an area of great concern. Currently, alternatives therapies are being sought to mitigate...
1 CitationsSource
#1Elham Hatami (UTHSC: University of Tennessee Health Science Center)H-Index: 6
#2Prashanth K.B. Nagesh (UTHSC: University of Tennessee Health Science Center)H-Index: 10
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
view all 5 authors...
Abstract Non-small cell lung cancer (NSCLC) is the most frequent type of lung cancer accounting up to 80–85% of all lung cancer (LC) cases. Gemcitabine (Gem), a pyrimidine nucleoside antimetabolite, is widely used chemotherapy offering several months survival benefit in patients with NSCLC. The emergence of Gem resistance is a main clinical concern in cancer treatment and thus a continuous demand for development of new therapeutic strategies to improve its antitumor activity. Hence, we report an...
2 CitationsSource
#1Vivek K. Kashyap (University of Texas at Austin)H-Index: 8
#2Anupam Dhasmana (University of Texas at Austin)H-Index: 7
Last. Meena Jaggi (University of Texas at Austin)H-Index: 1
view all 5 authors...
1 CitationsSource