David J. Gracie
University of Leeds
PsychiatryInternal medicineIntensive care medicinePhysical therapyImmunologyInfliximabInflammatory bowel diseaseIrritable bowel syndromeFaecal calprotectinDepression (differential diagnoses)DiseaseComorbidityCrohn's diseaseMEDLINEUlcerative colitisMoodPopulationAnxietyMedicineGastroenterologyMeta-analysis
85Publications
16H-index
1,168Citations
Publications 77
Newest
#1N. To (University of Leeds)H-Index: 7
#2David J. Gracie (University of Leeds)H-Index: 16
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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1 CitationsSource
#1N. To (University of Leeds)H-Index: 7
#2David J. Gracie (University of Leeds)H-Index: 16
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 3 authors...
Summary Background Tobacco smoking is a well-established risk factor for the development of Crohn's disease, and this may lead to a more complicated disease course. However, recent evidence suggests that many patients with Crohn's disease are unaware of this fact. Aim To perform a systematic review and meta-analysis of the effects of smoking on disease course in Crohn's disease. Methods A search of MEDLINE, EMBASE and EMBASE classic was carried out (up to July 2015) to identify observational stu...
87 CitationsSource
#1David J. Gracie (St James's University Hospital)H-Index: 16
#2Alexander C. Ford (St James's University Hospital)H-Index: 86
1 CitationsSource
Purpose of review: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder associated with significant physical and psychological co-morbidity. The aetiology of the condition is uncertain but recent research suggests the gut bacterial flora may play a role in its development. Therefore, manipulation of the intestinal microbiome by using probiotics and symbiotics has the potential to improve patient outcomes in IBS. Recent findings: Numerous randomised controlled trials (RCTs) sugge...
5 CitationsSource
#1Ruchit Sood (University of Leeds)H-Index: 13
#2David J. Gracie (University of Leeds)H-Index: 16
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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Summary Background Irritable bowel syndrome (IBS) is a complex, heterogeneous disease which can be challenging to diagnose. No study has identified and assessed the accuracy of all available methods of diagnosing IBS. Aim To conduct a systematic review of the literature to identify and assess accuracy of symptom-based diagnostic criteria, biomarkers, psychological markers or combinations thereof. Methods MEDLINE, EMBASE and EMBASE Classic were searched (until April 2015) to identify studies repo...
53 CitationsSource
#1David J. Gracie (University of Leeds)H-Index: 16
#2Premsyl Bercik (McMaster University)H-Index: 9
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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Background Psychological factors are associated with functional gastrointestinal (GI) disorders. Literature suggests that somatization is associated with functional dyspepsia (FD). However, the relationship between organic dyspepsia (OD), FD, and FD subtypes and somatization is poorly described. We aimed to examine this issue in a cross-sectional study of secondary care patients. Methods Demographic and GI symptom data were collected from 4224 adult patients via the Rome III questionnaire. Somat...
15 CitationsSource
#1Anthony O'Connor (St James's University Hospital)H-Index: 22
#2J Taylor (St James's University Hospital)
Last. PJ Hamlin (St James's University Hospital)H-Index: 9
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Introduction Follow-up of patients resected for Crohn’s disease (CD) have shown that in the absence of treatment, the post-operative recurrence rate is 70–90% within one year of the operation and 83–100% within 3 years. Prophylactic medication and disease monitoring has been proven to decrease the rate of clinical and endoscopic recurrence. Method We aimed to examine current practices in our large tertiary referral centre on postoperative prescriptions of disease modifying therapy for CD. We per...
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#1David J. Gracie (University of Leeds)H-Index: 16
#2Christopher J.M. Williams (St James's University Hospital)H-Index: 4
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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Introduction The Harvey-Bradshaw index (HBI) and simple clinical colitis activity index (SCCAI) are clinical scoring systems used to estimate Crohn’s disease (CD), and ulcerative colitis (UC) activity, respectively. However, whether they are superior to the patient’s own opinion at predicting disease activity, defined by faecal biomarkers of inflammatory bowel disease (IBD) activity is unclear. We conducted a cross-sectional survey of IBD patients to assess these issues. Method Patient opinion a...
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#1David J. Gracie (University of Leeds)H-Index: 16
#2Christopher J.M. Williams (St James's University Hospital)H-Index: 4
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 7 authors...
Introduction The prevalence of symptoms compatible with irritable bowel syndrome (IBS) in inflammatory bowel disease (IBD) has been previously described.1However, the association between the presence of these symptoms and occult disease activity is less well known, as is the effect of these symptoms on psychological health. We conducted a cross-sectional survey examining these issues. Method Demographic and gastrointestinal symptom data were collected from 439 adult patients via the Rome III que...
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#1Victoria WarrenH-Index: 1
#2Amer F. RehmanH-Index: 1
Last. Christian P. SelingerH-Index: 25
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