Gaia Spinetti
University of Bristol
Internal medicineEndocrinologyPathologyProgenitor cellImmunologyOxidative stressEndotheliumNeovascularizationVascular smooth muscleBone marrowAngiogenesisPericyteCritical limb ischemiaStem cellCancer researchIschemiaDiabetes mellitusMedicineBiologyCell biology
123Publications
33H-index
3,686Citations
Publications 114
Newest
#1Germana ZaccagniniH-Index: 17
#2Simona GrecoH-Index: 30
Last. Fabio MartelliH-Index: 53
view all 14 authors...
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#1Fabiana Passaro (University of Naples Federico II)H-Index: 11
#2Carlo G. Tocchetti (University of Naples Federico II)H-Index: 38
Last. Gianluca Testa (UNIMOL: University of Molise)H-Index: 25
view all 9 authors...
Abstract Heart failure (HF) is a clinical syndrome characterized by typical symptoms and signs caused by a structural and/or functional cardiac abnormality, resulting in a reduced cardiac output and/or elevated intracardiac pressures at rest or during stress. Due to increasing incidence, prevalence and, most importantly mortality, HF is a healthcare burden worldwide, despite the improvement of treatment options and effectiveness. Acute and chronic cardiac injuries trigger the activation of neuro...
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Hypoxia-induced miR-210 is a crucial component of the tissue response to ischemia, stimulating angiogenesis and improving tissue regeneration. Previous analysis of miR-210 impact on the transcriptome in a mouse model of hindlimb ischemia showed that miR-210 regulated not only vascular regeneration functions, but also inflammation. To investigate this event, doxycycline-inducible miR-210 transgenic mice (Tg-210) and anti-miR-210 LNA-oligonucleotides were used. It was found that global miR-210 exp...
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#1Gaia SpinettiH-Index: 33
#2Elisa Avolio (UoB: University of Bristol)H-Index: 13
Last. Paolo Madeddu (UoB: University of Bristol)H-Index: 64
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In many countries, COVID-19 now accounts for more deaths per year than car accidents and even the deadliest wars. Combating the viral pandemics requires a coordinated effort to develop therapeutic protocols adaptable to the disease severity. In this review article, we summarize a graded approach aiming to shield cells from SARS-CoV-2 entry and infection, inhibit excess inflammation and evasion of the immune response, and ultimately prevent systemic organ failure. Moreover, we focus on mesenchyma...
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#2Niall Sullivan (Southmead Hospital)H-Index: 5
Last. Paolo Madeddu (UoB: University of Bristol)H-Index: 64
view all 10 authors...
Background: Chronic low-grade inflammation and alterations in innate and adaptive immunity were reported in Type 2 diabetes (T2D). Here, we investigated the abundance and activation of T cells in the bone marrow (BM) of patients with T2D. We then verified the human data in a murine model and tested if the activation of T cells can be rescued by treating mice with abatacept, an immunomodulatory drug employed for the treatment of rheumatoid arthritis. Clinical evidence indicated abatacept can slow...
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#1Yue Gu (UoB: University of Bristol)H-Index: 2
Last. Paolo Madeddu (UoB: University of Bristol)H-Index: 64
view all 5 authors...
PURPOSE OF REVIEW To provide a highlight of the current state of cell therapy for the treatment of critical limb ischemia in patients with diabetes. RECENT FINDINGS The global incidence of diabetes is constantly growing with consequent challenges for healthcare systems worldwide. In the UK only, NHS costs attributed to diabetic complications, such as peripheral vascular disease, amputation, blindness, renal failure, and stroke, average £10 billion each year, with cost pressure being estimated to...
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#1Elisa Avolio (UoB: University of Bristol)H-Index: 13
#2Anita C Thomas (UoB: University of Bristol)H-Index: 26
Last. Paolo Madeddu (UoB: University of Bristol)H-Index: 64
view all 15 authors...
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#1Germana ZaccagniniH-Index: 17
#2Simona GrecoH-Index: 30
Last. Fabio MartelliH-Index: 53
view all 13 authors...
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#1Marcello Marelli (National Research Council)H-Index: 22
#2Filippo Bossola (National Research Council)H-Index: 8
Last. Laura Polito (National Research Council)H-Index: 1
view all 7 authors...
Anisotropic gold nanoparticles (AuNPs), with their unique physical and optical properties, are emerging as smart and key nanomaterials, and are being exploited in many crucial fields. To further improve their range of action, anisotropic AuNPs have been coupled with semiconductors, mainly TiO2 (titania), receiving great interest as powerful platforms both in biomedicine and in catalytic applications. Such hybrid nanoparticles show new properties that arise from the synergic action of the compone...
3 CitationsSource
#1Ashton Faulkner (UoB: University of Bristol)H-Index: 5
#2Anita Tamiato (UoB: University of Bristol)H-Index: 1
Last. Paolo Madeddu (UoB: University of Bristol)H-Index: 64
view all 12 authors...
Treatment of vascular complications of diabetes remains inadequate. We reported that muscle pericytes (MPs) from limb muscles of vascular patients with diabetes mellitus display elevated levels of oxidative stress causing a dysfunctional phenotype. Here, we investigated whether treatment with dimethyl-2-oxoglutarate (DM-2OG), a tricarboxylic acid cycle metabolite with antioxidant properties, can restore a healthy metabolic and functional phenotype. MPs were isolated from limb muscles of diabetes...
5 CitationsSource