Lolkje T. W. de Jong-van den Berg
University of Groningen
PharmacyPsychiatryInternal medicineObstetricsCase-control studyIntensive care medicinePediatricsCohort studyAlternative medicinePharmacoepidemiologyMedical prescriptionPregnancyMEDLINEDrugPopulationGynecologyFamily medicinePharmacovigilanceMedicinePharmacology
Publications 232
We aimed to assess prevalence, birth outcome, associated anomalies and prenatal diagnosis of congenital clubfoot in Europe using data from the EUROCAT network, and to validate the recording of congenital clubfoot as a major congenital anomaly by EUROCAT registries. Cases of congenital clubfoot were included from 18 EUROCAT registries covering more than 4.8 million births in 1995-2011. Cases without chromosomal anomalies born during 2005-2009, were randomly selected for validation using a questio...
Objectives To evaluate the risk of major congenital anomaly associated with first-trimester exposure to insulin analogues compared with human insulin in offspring of women with pregestational diabetes. Design and setting A population-based cohort of women with pregestational diabetes (n=1661) who delivered between 1996 and 2012 was established retrospectively from seven European regions covered bythe European Surveillance of Congenital Anomalies (EUROCAT) congenital anomaly registries. Primary o...
Background: Antihypertensive drugs are used during pregnancy for both chronic hypertension and gestational hypertension. Methyldopa, labetalol and nifedipine are considered safe for the fetus during pregnancy and are therefore recommended in the Dutch guidelines. Objectives: To determine how often antihypertensive drugs are prescribed in pregnancy and whether recommended drugs are prescribed. Methods: Using, a database with prescription records of 500,000 people in the Netherlands we inv...
#1J.M. Luteijn (QMUL: Queen Mary University of London)H-Index: 14
#2Joan K. Morris (QMUL: Queen Mary University of London)H-Index: 68
Last. Kari Klungsøyr (FHI: Norwegian Institute of Public Health)H-Index: 42
view all 21 authors...
Aims Information about medication safety in pregnancy is inadequate. We aimed to develop a signal detection methodology to routinely identify unusual associations between medications and congenital anomalies using data collected by 15 European congenital anomaly registries. Methods EUROmediCAT database data for 14 950 malformed foetuses/babies with first trimester medication exposures in 1995–2011 were analyzed. The odds of a specific medication exposure (coded according to chemical substance or...
#1Josta de Jong (UG: University of Groningen)H-Index: 5
#2Ester GarneH-Index: 46
Last. Hao Wang (UG: University of Groningen)H-Index: 8
view all 4 authors...
Background More information is needed about possible associations between the newer anti-epileptic drugs (AEDs) in the first trimester of pregnancy and specific congenital anomalies of the fetus.
#1Rachel Charlton (University of Bath)H-Index: 15
#2Kari Klungsøyr (FHI: Norwegian Institute of Public Health)H-Index: 42
Last. Ester GarneH-Index: 46
view all 19 authors...
Aim To explore antidiabetic medicine prescribing to women before, during and after pregnancy in different regions of Europe.
#1Akin Özyilmaz (UMCG: University Medical Center Groningen)H-Index: 7
#2Cornelis Boersma (UG: University of Groningen)H-Index: 15
Last. Ron T. Gansevoort (UMCG: University Medical Center Groningen)H-Index: 104
view all 8 authors...
Background: It is not clear which hypercholesterolemic patients benefit most from beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors with respect to the prevention of cardiovascular events. Early signs of atherosclerotic vascular damage may identify high-risk patients. Design: We studied whether subjects with hypercholesterolemia will benefit more from starting statin treatment in the case of high albuminuria and/or high-sensitivity C-reactive protein (hsCRP). Methods: Included wer...
#1Josta de Jong (UG: University of Groningen)H-Index: 5
#2Ester GarneH-Index: 46
Last. Hao Wang (UG: University of Groningen)H-Index: 8
view all 6 authors...
BACKGROUND: Insulin analogues are commonly used in pregnant women with diabetes. It is not known if the use of insulin analogues in pregnancy is associated with any higher risk of congenital anomalies in the offspring compared with use of human insulin. METHODS: We performed a literature search for studies of pregnant women with pregestational diabetes using insulin analogues in the first trimester and information on congenital anomalies. The studies were analyzed to compare the congenital anoma...
#1Nancy A Dreyer (IQVIA: Quintiles)H-Index: 30
#2Stella Blackburn (IQVIA: Quintiles)H-Index: 6
view all 11 authors...
Background: Little is known about the effects of human fetal exposure when a new drug is authorized unless it was specifically developed for use in pregnancy. Since many factors may contribute to adverse fetal effects, having comprehensive information about in utero exposures will enhance our ability to make correct determinations about causality. Objective: The objective of the study was to assess the extent to which women, recruited without the intervention of health care professionals (HCPs),...
BACKGROUND: In the context of the European Surveillance of Congenital Anomalies (EUROCAT) surveillance response to the 2009 influenza pandemic, we sought to establish whether there was a detectable increase of congenital anomaly prevalence among pregnancies exposed to influenza seasons in general, and whether any increase was greater during the 2009 pandemic than during other seasons. METHODS: We performed an ecologic time series analysis based on 26,967 pregnancies with nonchromosomal congenita...
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