Sisto Perdonà
University of Naples Federico II
CancerInternal medicineUrologySurgeryPathologyOncologyRenal functionRetrospective cohort studyCystectomyBiopsyProstateChemotherapyRenal cell carcinomaProstate cancerNephrectomyBladder cancerProstate biopsyProstate-specific antigenGynecologyCancer researchMedicineBiology
148Publications
41H-index
3,565Citations
Publications 148
Newest
#1Matteo Ferro (IEO: European Institute of Oncology)H-Index: 29
#2Daniela Terracciano (University of Naples Federico II)H-Index: 26
Last. Francesco A. Mistretta (IEO: European Institute of Oncology)H-Index: 14
view all 0 authors...
INTRODUCTION The association between obesity and clinically significant prostate cancer (PCa) is still a matter of debate. In this study, we evaluated the effect of body mass index (BMI) on the prediction of pathological unfavorable disease (UD), positive surgical margins (PSMs), and biochemical recurrence (BCR) in patients with clinically localized (≤cT2c) International Society of Urological Pathology (ISUP) grade group 1 PCa at biopsy. METHODS 427 patients with ISUP grade group 1 PCa who have ...
Source
#1Matteo Ferro (IEO: European Institute of Oncology)H-Index: 29
#2Ottavio De Cobelli (IEO: European Institute of Oncology)H-Index: 31
Last. Carlo BuonerbaH-Index: 27
view all 45 authors...
Background. Three or four cycles of cisplatin-based chemotherapy is the standard neoadjuvant treatment prior to cystectomy in patients with muscle-invasive bladder cancer. Although NCCN guidelines recommend 4 cycles of cisplatin-gemcitabine, three cycles are also commonly administered in clinical practice. In this multicenter retrospective study, we assessed a large and homogenous cohort of patients with urothelial bladder cancer (UBC) treated with three or four cycles of neoadjuvant cisplatin-g...
Source
#1Rossella Di FrancoH-Index: 10
#2V. BorzilloH-Index: 5
Last. Paolo MutoH-Index: 16
view all 19 authors...
BACKGROUND The use of intra-fractional monitoring and correction of prostate position with the Image Guided Radio Therapy (IGRT) system can increase the spatial accuracy of dose delivery. Clarity is a system used for intrafraction prostate-motion management, it provides a real-time visualization of prostate with a transperineal ultrasound. The aim of this study was to evaluate the use of Clarity-IGRT on proper intrafraction alignment and monitoring, its impact on Planning Tumor Volume margin and...
Source
Aim: To investigate the prognostic role of neutrophil percentage-to-albumin ratio (NPAR) in muscle-invasive bladder cancer (MIBC) patients treated with neoadjuvant chemotherapy (NAC) and radical cy...
Source
BACKGROUND The high-risk human papillomavirus (HPV) infection represents one of the main etiologic pathways of penile carcinogenesis in approximately 30-50 % of cases. Several techniques for the detection of HPV are currently available including Polymerase chain reaction-based techniques, DNA and RNA in situ hybridization (ISH), p16 immunohistochemistry (IHC). The multiplex HPV RNA ISH/p16 IHC is a novel technique for the simultaneous detection of HPV E6/E7 transcripts and p16INK4a overexpressio...
Source
#1Sara Terreri (National Research Council)H-Index: 7
#2Sara Mancinelli (National Research Council)H-Index: 2
Last. Amelia Cimmino (National Research Council)H-Index: 31
view all 22 authors...
Non-coding RNA transcripts originating from Ultraconserved Regions (UCRs) have tissue-specific expression and play relevant roles in the pathophysiology of multiple cancer types. Among them, we recently identified and characterized the ultra-conserved-transcript-8+ (uc.8+), whose levels correlate with grading and staging of bladder cancer. Here, to validate uc.8+ as a potential biomarker in bladder cancer, we assessed its expression and subcellular localization by using tissue microarray on 73 h...
Source
#2Marco FabianoH-Index: 1
Last. Paolo FedeliniH-Index: 4
view all 9 authors...
Introduction:Over the years, the robotic surgery is gaining increasing importance in the treatment of bladder cancer. Some doubts remain about the oncological safety of robotic approach and alerts ...
Source
#1Matteo Ferro (IEO: European Institute of Oncology)H-Index: 29
#2Marina Di Mauro (University of Catania)H-Index: 7
Last. Giorgio Ivan Russo (University of Catania)H-Index: 33
view all 32 authors...
Background An accurate and early diagnosis of bladder cancer (BC) is essential to offer patients the most appropriate treatment and the highest cure rate. For this reason, patients need to be best stratified by class and risk factors. We aimed to develop a score able to better predict cancer outcomes, using serum variables of inflammation. Methods A total of 1,510 high-risk non-muscle invasive bladder cancer (NMIBC) patients were included in this retrospective observational study. Patients with ...
Source
#1Matteo Ferro (IEO: European Institute of Oncology)H-Index: 29
#2Michele MarchioniH-Index: 15
Last. Luigi SchipsH-Index: 37
view all 38 authors...
Introduction We aimed to test the hypothesis that the immune-modulatory effect of statins may improve survival outcomes in patients with non-muscle invasive bladder cancer (NMIBC). We focused on a cohort of patients diagnosed with high risk NMIBC, that were treated with intravesical BCG immunotherapy. Patients and methods We included patients at first diagnosis of T1 high grade NMIBC after transurethral resection of bladder (TURB). All procedures were performed at 18 different tertiary instituti...
Source
#1Rosa TambaroH-Index: 16
#2Marilena Di NapoliH-Index: 13
Last. Sandro PignataH-Index: 4
view all 14 authors...
Monoclonal antibodies targeting the checkpoint inhibitors (CPIs), programmed cell death protein-1 or programmed cell death ligand-1, are changing the landscape of urothelial carcinoma therapeutics. Overall, clinical studies in metastatic or advanced urothelial cancer showed that CPIs provided a slight improvement in survival and a relevant advantage in safety, compared with chemotherapy. After reviewing published and ongoing trials, the authors discuss expected answers to unmet needs, with a spe...
1 CitationsSource