Katherine J. Bangen
Veterans Health Administration
Internal medicineNeuropsychologyPathologyOncologyPsychologyCerebral blood flowCardiologyNeuroscienceCognitionEffects of sleep deprivation on cognitive performanceDiseaseDementiaTraumatic brain injuryCognitive declineCognitive impairmentAlzheimer's diseaseAudiologyApolipoprotein ENeuroimagingClinical psychologyMedicineGerontology
105Publications
29H-index
2,591Citations
Publications 103
Newest
#1Katherine J. Bangen (Veterans Health Administration)H-Index: 29
#2Denis S. Smirnov (UCSD: University of California, San Diego)H-Index: 4
Last. Douglas Galasko (UCSD: University of California, San Diego)H-Index: 125
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Background null Arterial stiffening has emerged as an important risk factor for Alzheimer's disease (AD) and related dementias. Carotid-femoral pulse wave velocity has been proposed as a non-invasive and reproducible method to assess arterial stiffness. However, the association of pulse wave velocity with performance across multiple cognitive domains as well as interactions with in vivo AD biomarkers and apolipoprotein E (APOE) genotype has received limited study. null Method null We studied 193...
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#1Kelsey R. Thomas (UCSD: University of California, San Diego)H-Index: 15
#2Jessica R. Osuna (UCSD: University of California, San Diego)H-Index: 3
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Although cerebral blood flow (CBF) alterations are associated with Alzheimer’s disease (AD), CBF patterns across prodromal stages of AD remain unclear. Therefore, we investigated patterns of region...
2 CitationsSource
#1Isabel J. Sible (SC: University of Southern California)H-Index: 1
#2Belinda Yew (SC: University of Southern California)H-Index: 2
Last. Daniel A. Nation (UCI: University of California, Irvine)H-Index: 28
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ABSTRACT Blood pressure variability is linked to dementia risk, possibly through cerebral hypoperfusion. We investigated blood pressure variability over one year and concurrent regional cerebral perfusion decline in older adults without dementia. Participants underwent four blood pressure measurements across 12 months, ASL-MRI at baseline and 12-months, and baseline FDG-PET. Regional perfusion was normalized to precentral gyrus. A subset had cerebral spinal fluid Alzheimer's disease biomarker ab...
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#1Katherine J. Bangen (Veterans Health Administration)H-Index: 29
#2Kelsey R. Thomas (Veterans Health Administration)H-Index: 15
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INTRODUCTION Neurofilament light (NFL) reflects neuroaxonal damage and is implicated in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Little is known about NFL in pre-MCI stages, such as in individuals with objectively-defined subtle cognitive decline (Obj-SCD). METHODS Two hundred ninety-four participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) underwent baseline blood draw and serial neuropsychological testing over 5 years of follow-up. RESULTS Individuals w...
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#1Katherine J. BangenH-Index: 29
#2Lisa Delano-Wood (UCSD: University of California, San Diego)H-Index: 32
Last. Melissa Lamar (Rush University Medical Center)H-Index: 30
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Alterations to cerebral white matter tracts have been associated with cognitive decline in aging and Alzheimer's disease (AD). In particular, the fornix has been implicated as especially vulnerable given that it represents the primary outflow tract of the hippocampus. Despite this, little work has focused on the fornix using a potential early marker of white matter degeneration-myelin water fraction (MWF; an in vivo marker of myelin content). Therefore, we sought to (1) clarify associations betw...
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#1Alexandra L. Clark (UCSD: University of California, San Diego)H-Index: 13
#2Alexandra J. Weigand (UCSD: University of California, San Diego)H-Index: 8
Last. Lisa Delano-Wood (UCSD: University of California, San Diego)H-Index: 32
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Mild traumatic brain injury (mTBI) is a risk factor for Alzheimer’s disease (AD), and evidence suggests cerebrovascular dysregulation initiates deleterious neurodegenerative cascades. We examined w...
2 CitationsSource
#1Alison X. Chan (UCSD: University of California, San Diego)H-Index: 1
#2Christine Y. Bakhoum (UCSD: University of California, San Diego)H-Index: 2
Last. Mathieu F. Bakhoum (UCSD: University of California, San Diego)H-Index: 7
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PURPOSE To examine the association between cognitive dementia and retinal vascular occlusions. DESIGN A retrospective, cross-sectional study. METHODS Setting: Single institution Study population: We reviewed the electronic medical records of 37,208 individuals older than 65 years of age who were evaluated by an ophthalmologist or an optometrist and who also had a medical visit at our institution over a 6-year period. Individuals with and without retinal vascular occlusions were identified throug...
1 CitationsSource
#1Alexandra L. Clark (UCSD: University of California, San Diego)H-Index: 13
#2Alexandra J. Weigand (UCSD: University of California, San Diego)H-Index: 8
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BACKGROUND Age-related cerebrovascular and neuroinflammatory processes have been independently identified as key mechanisms of Alzheimer's disease (AD), although their interactive effects have yet to be fully examined. OBJECTIVE The current study examined 1) the influence of pulse pressure (PP) and inflammatory markers on AD protein levels and 2) links between protein biomarkers and cognitive function in older adults with and without mild cognitive impairment (MCI). METHODS This study included 2...
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#1Katherine J. Bangen (UCSD: University of California, San Diego)H-Index: 29
#2Kelsey R. Thomas (UCSD: University of California, San Diego)H-Index: 15
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BACKGROUND Altered cerebral blood flow (CBF) has been linked to increased risk for Alzheimer's disease (AD). However, whether altered CBF contributes to AD risk by accelerating cognitive decline remains unclear. It also remains unclear whether reductions in CBF accelerate neurodegeneration and development of small vessel cerebrovascular disease. OBJECTIVE To examine associations between CBF and trajectories of memory performance, regional brain atrophy, and global white matter hyperintensity (WM...
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#1Alexandra J. Weigand (UCSD: University of California, San Diego)H-Index: 8
#2Kelsey R. Thomas (UCSD: University of California, San Diego)H-Index: 15
Last. Alzheimer’s Disease Neuroimaging Initiative (UCSD: University of California, San Diego)H-Index: 6
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Introduction Apolipoprotein E (APOE) interacts with Alzheimer's disease pathology to promote disease progression. We investigated the moderating effect of APOE on independent associations of amyloid and tau positron emission tomography (PET) with cognition. Methods For 297 nondemented older adults from the Alzheimer's Disease Neuroimaging Initiative, regression equations modeled associations between cognition and (1) cortical amyloid beta (Aβ) PET levels adjusting for tau and (2) medial temporal...
5 CitationsSource