Francesca Casalini
University of Pisa
Matrix metalloproteinaseChemical synthesisBiological activityDocking (molecular)EnzymeChemistryIn vitroCombinatorial chemistryMatrix metalloproteinase inhibitorOsteoarthritisGlioblastomaHydroxamic acidTemozolomideGliomaCollagenaseALCAMActivated-Leukocyte Cell Adhesion MoleculeBiological evaluationHigh selectivityCancer researchBiochemistryMedicineCell cultureCell biologyPharmacology
Publications 27
#1Francesca Casalini (UniPi: University of Pisa)H-Index: 10
#2Susanna Salvetti (UniPi: University of Pisa)H-Index: 1
Last. Gaetano Pierpaolo Privitera (UniPi: University of Pisa)H-Index: 21
view all 7 authors...
Objective: To propose an easy predictive model for the risk of rehospitalization, built from hospital administrative data, in order to prevent repeated admissions and to improve transitional care. Design: Retrospective cohort study. Setting: Azienda Ospedaliero Universitaria Pisana (Pisa University Hospital). Participants: Patients residing in the territory of the province of Pisa (Tuscany Region) with at least one unplanned hospital admission leading to a medical Diagnosis-Related Group (DRG) i...
11 CitationsSource
Despite the increase of community acquired cases of legionellosis in Italy over the last years, the Italian guidelines do not give indications for prevention and control of Legionella in the hot water networks (or centralized conditioning systems) of residential buildings. We performed a survey on eight medium sized apartment buildings in the Pisa district to assess the prevalence of Legionella spp. in the water network and the respondance to drinking water requisites at the point of use, accord...
6 CitationsSource
#1Silvia MemminiH-Index: 2
#2Simona BarniniH-Index: 3
Last. Beatrice CasiniH-Index: 15
view all 10 authors...
#1Giulio Perugi (UniPi: University of Pisa)H-Index: 58
#2Giuseppe Quaranta (UniPi: University of Pisa)H-Index: 4
Last. Liliana Dell׳Osso (UniPi: University of Pisa)H-Index: 5
view all 7 authors...
Abstract Background Patients with bipolar disorder (BD) suffer from greater physical morbidity and mortality than the general population. The aim of the present study is to explore the prevalence and clinical correlates of General Medical Conditions (GMC) in a large consecutive sample of patients with BD. Method The study sample comprised of 347 patients who met DSM-IV -TR criteria for BD I ( n =207, 59.7%), BD II or Cyclothymic Disorder ( n =140, 40.3). Diagnostic information was collected by m...
57 CitationsSource
#1Giuseppe DigilioH-Index: 18
#2Tiziano Tuccinardi (UniPi: University of Pisa)H-Index: 35
Last. Armando Rossello (UniPi: University of Pisa)H-Index: 28
view all 9 authors...
Abstract Fluorinated, arylsulfone-based inhibitors of Matrix Metalloproteinases (MMP) have been used, in the [ 18 F]-radiolabelled version, as radiotracers targeted to MMP-2/9 for Positron Emission Tomography (PET). Although they showed acceptable tumour uptake, specificity was rather low. To get further insights into the reason of low specificity, the binding interaction of these compounds with Human Serum Albumin (HSA) has been investigated. 19 F NMR spectroscopy showed that all compounds cons...
10 CitationsSource
#1Elisa Nuti (UniPi: University of Pisa)H-Index: 25
#2Francesca Casalini (UniPi: University of Pisa)H-Index: 10
Last. Armando Rossello (UniPi: University of Pisa)H-Index: 28
view all 13 authors...
Activated leukocyte cell adhesion molecule (ALCAM) is expressed at the surface of epithelial ovarian cancer (EOC) cells and is released in a soluble form (sALCAM) by ADAM-17-mediated shedding. This process is relevant to EOC cell motility and invasiveness, which is reduced by inhibitors of ADAM-17. In addition, ADAM-17 plays a key role in EGFR signaling and thus may represent a useful target in anticancer therapy. Herein we report our hit optimization effort to identify potent and selective ADAM...
15 CitationsSource
#1Elisa Nuti (UniPi: University of Pisa)H-Index: 25
#2Salvatore Santamaria (University of Oxford)H-Index: 14
Last. Armando Rossello (UniPi: University of Pisa)H-Index: 28
view all 15 authors...
Abstract Aggrecanases, in particular aggrecanase-2 (ADAMTS-5), are considered the principal proteases responsible for aggrecan degradation in osteoarthritis. For this reason, considerable effort has been put on the discovery and development of aggrecanase inhibitors able to slow down or halt the progression of osteoarthritis. We report herein the synthesis and biological evaluation of a series of arylsulfonamido-based hydroxamates as aggrecanase inhibitors. Compound 18 was found to have a nanomo...
34 CitationsSource
Last. Alessandro MaiocchiH-Index: 14
view all 13 authors...
Abstract Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly patients, and is characterized by progressive loss of articular cartilage. Among the various matrix metalloproteinases (MMPs), MMP-13 is specifically expressed in the cartilage of human OA patients and is not present in normal adult cartilage. Thus, MMP-13-selective inhibitors are promising candidates in osteoarthritis therapy. Recently, we designed an N -isopropoxy-arylsulfonamide-based hyd...
21 CitationsSource
#1Elisa Nuti (UniPi: University of Pisa)H-Index: 25
#2Francesca Casalini (UniPi: University of Pisa)H-Index: 10
Last. Armando Rossello (UniPi: University of Pisa)H-Index: 28
view all 15 authors...
Matrix metalloproteinases (MMPs) are important factors in gliomas since these enzymes facilitate invasion into the surrounding brain and participate in neovascularization. In particular, the gelatinases (MMP-2 and MMP-9), and more recently MMP-25, have been shown to be highly expressed in gliomas and have been associated with disease progression. Thus, inhibition of these MMPs may represent a promising non-cytotoxic approach to glioma treatment. We report herein the synthesis and biological eval...
27 CitationsSource