Mojtaba Akhtari
University of Southern California
Internal medicineSurgeryPathologyOncologyPediatricsImmunologyChemotherapyNeutropeniaHematopoietic stem cell transplantationLeukemiaMyeloid leukemiaDiseaseMyeloidDasatinibGraft-versus-host diseaseStem cellTransplantationCancer researchMedicineBiologyGastroenterology
94Publications
18H-index
1,052Citations
Publications 91
Newest
#1Tian Zhang (SC: University of Southern California)H-Index: 3
#2Jiawen Yang (SC: University of Southern California)H-Index: 3
Last. Houda Alachkar (SC: University of Southern California)H-Index: 15
view all 7 authors...
Acute myeloid leukemia (AML) is a devastating hematologic malignancy that affects the hematopoietic stem cells. The 5-year overall survival (OS) of patients with AML is less than 30%, highlighting the urgent need to identify new therapeutic targets. Here, we analyze gene expression datasets for genes that are differentially overexpressed in AML cells compared with healthy hematopoietic cells. We report that apolipoprotein C2 (APOC2) mRNA is significantly overexpressed in AML, particularly in pat...
Source
#1Vijaya Pooja Vaikari (SC: University of Southern California)H-Index: 5
#2Yang Du (SC: University of Southern California)H-Index: 2
Last. Houda Alachkar (SC: University of Southern California)H-Index: 15
view all 10 authors...
In an effort to identify target genes in acute myeloid leukemia, we compared gene expression profiles between normal and acute myeloid leukemia cells from various publicly available datasets. We identified CD99, a gene that is upregulated in patients with acute myeloid leukemia. In 186 patients from The Cancer Genome Atlas - acute myeloid leukemia dataset, CD99 was overexpressed in patients with FLT3-ITD and was downregulated in patients with TP53 mutations. CD99 is a transmembrane protein expre...
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#1Jeremy Chang (SC: University of Southern California)H-Index: 3
#2Sherry Zhang (UCLA Medical Center)H-Index: 3
Last. Mojtaba AkhtariH-Index: 18
view all 3 authors...
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#1Mindy Hsiao (SC: University of Southern California)H-Index: 1
#2George Yaghmour (SC: University of Southern California)H-Index: 7
Last. Mojtaba Akhtari (SC: University of Southern California)H-Index: 18
view all 3 authors...
Source
#1Houda Alachkar (SC: University of Southern California)H-Index: 15
#2Vijaya Pooja Vaikari (SC: University of Southern California)H-Index: 5
Last. Mojtaba Akhtari (SC: University of Southern California)H-Index: 18
view all 9 authors...
Outcome of patients with Acute Myeloid Leukemia (AML) remains dismal and the need for new therapies is high. We recently found CD99 to be upregulated in AML and showed that CD99 loss of function by siRNA or anti-CD99 antibody decreased proliferation of AML cells. Here, we investigate the functional role of CD99 wild type isoform (WT) in AML with the hypothesis that CD99 ectopic expression results in more aggressive leukemia. We found that transducing cells with CD99 lentivirus resulted in initia...
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#1Jeremy Chang (SC: University of Southern California)H-Index: 3
#2Dan DouerH-Index: 45
Last. Mojtaba AkhtariH-Index: 18
view all 11 authors...
BACKGROUND: The Philadelphia chromosome is associated with a poor prognosis in acute lymphoblastic leukemia (ALL). While hematopoietic stem cell transplantation (HSCT) has been regarded as a favorable treatment option in adult Philadelphia-positive (Ph+) ALL, its benefit is less clear in the era of newer generation tyrosine kinase inhibitors (TKIs) like dasatinib. METHODS: This was a retrospective study that analyzed the outcomes of adult patients with Ph+ ALL treated with either combination che...
Source
#1Aref Al-KaliH-Index: 25
#2Ibrahim AldossH-Index: 23
Last. Scott H. KaufmannH-Index: 117
view all 9 authors...
e18506Background: Sapanisertib (SAP) is an oral small molecule dual mTOR complex 1 and 2 (TORC1/2) inhibitor that showed activity in lymphoid neoplasms. It blocks a feedback loop involving mTORC2 a...
Source
#1Jeremy Chang (SC: University of Southern California)H-Index: 3
#2Mojtaba Akhtari (SC: University of Southern California)H-Index: 18
7024Background: Philadelphia Chromosome-Positive (Ph+) disease is associated with a poor prognosis in acute lymphoblastic leukemia (ALL). Recent studies have shown that the eradication of minimal r...
Source
#1Jeremy ChangH-Index: 3
#2Mindy HsiaoH-Index: 1
Last. Mojtaba AkhtariH-Index: 18
view all 4 authors...
Background: While haploidentical transplantation has led to the near-universal availability of donors, several challenges for this form of transplant still exist. This study sought to investigate the rates of infection-related mortality and other complications following haploidentical vs nonhaploidentical transplant. Methods: We conducted a retrospective cohort study in adults with various malignant and benign hematological conditions who underwent allogeneic hematopoietic stem cell transplantat...
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#1David J. Hermel (SC: University of Southern California)H-Index: 3
#2Victor Chiu (SC: University of Southern California)H-Index: 3
Last. Mojtaba Akhtari (SC: University of Southern California)H-Index: 18
view all 5 authors...
Preclinical animal studies have demonstrated an association between maternal use of tyrosine kinase inhibitors and embryofetal toxicity; yet, multiple clinical case series have reported normal pregnancy outcomes and healthy infants in women on these medications during the course of their pregnancy. We describe a case of a woman with chronic myeloid leukemia who had taken the second-generation tyrosine kinase inhibitor dasatinib during the first 12 weeks of her dichorionic diamniotic twin pregnan...
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