Ulrich Beuers
University of Amsterdam
EndocrinologyPathologyChemistryImmunologyLiver diseaseAutoimmune hepatitisCirrhosisAutoimmune pancreatitisCholestasisCholestatic pruritusDiseaseCholestasis of pregnancyBile acidLiver transplantationPrimary biliary cirrhosisPrimary sclerosing cholangitisUrsodeoxycholic acidMedicineBiologyGastroenterology
408Publications
66H-index
14.8kCitations
Publications 437
Newest
#1Marian Troelstra (UvA: University of Amsterdam)H-Index: 4
#2Julia J. Witjes (UvA: University of Amsterdam)H-Index: 6
Last. Adriaan G. Holleboom (UvA: University of Amsterdam)H-Index: 21
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BACKGROUND Noninvasive diagnostic methods are urgently required in disease stratification and monitoring in nonalcoholic fatty liver disease (NAFLD). Multiparametric magnetic resonance imaging (MRI) is a promising technique to assess hepatic steatosis, inflammation, and fibrosis, potentially enabling noninvasive identification of individuals with active and advanced stages of NAFLD. PURPOSE To examine the diagnostic performance of multiparametric MRI for the assessment of disease severity along ...
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#1David C. Trampert (UvA: University of Amsterdam)H-Index: 1
#2Stan F.J. van de Graaf (UvA: University of Amsterdam)H-Index: 28
Last. Ulrich Beuers (UvA: University of Amsterdam)H-Index: 66
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#1Fadi RassamH-Index: 6
#2Pim B. OlthofH-Index: 12
Last. Thomas M. van GulikH-Index: 60
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#1M Reich (HHU: University of Düsseldorf)H-Index: 8
#2Lina Spomer (HHU: University of Düsseldorf)H-Index: 8
Last. Verena Keitel (HHU: University of Düsseldorf)H-Index: 36
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Abstract Background&Aims Primary sclerosing cholangitis (PSC) is characterized by chronic inflammation and progressive fibrosis of the biliary tree. The bile acid receptor TGR5 is found on biliary epithelial cells (BECs), where it promotes secretion, proliferation and tight junction integrity. Thus, we speculated that changes in TGR5-expression in BECs may contribute to PSC pathogenesis. Methods TGR5-expression and -localization were analyzed in PSC livers and liver tissue, isolated bile ducts a...
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#1Jacqueline Langedijk (UvA: University of Amsterdam)H-Index: 2
#2Ruth Bolier (UvA: University of Amsterdam)H-Index: 11
Last. Ronald P.J. Oude Elferink (UvA: University of Amsterdam)H-Index: 63
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Pruritus is one of the most distressing symptoms in cholestatic patients. Plasma autotaxin (ATX) activity correlates with the severity of pruritus in cholestatic patients, but the pathophysiology is unclear. To study pruritus in mice, we measured scratch activity in cholestatic Atp8b1 mutant mice, a model for Progressive Familial Intrahepatic Cholestasis type 1, and wild type mice (WT) with alpha-naphthylisothiocyanate (ANIT)-induced cholestasis. To induce cholestasis, Atp8b1 mutant mice receive...
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#1Jacqueline Langedijk (UvA: University of Amsterdam)H-Index: 2
#2Ulrich Beuers (UvA: University of Amsterdam)H-Index: 66
Last. Ronald P.J. Oude Elferink (UvA: University of Amsterdam)H-Index: 63
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Pruritus is associated with multiple cholestatic disorders, including primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and inherited progressive familial intrahepatic cholestasis (PFIC). Chronic pruritus is, besides fatigue, the most debilitating symptom in these disorders. Consequently, patients suffer from sleep deprivation, loss of concentration, auto-mutilation and sometimes even suicidal ideations. Current therapy consists of four consecutive recommended treatments, w...
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#1Elsemieke de Vries (UvA: University of Amsterdam)H-Index: 5
#2Ruth Bolier (UvA: University of Amsterdam)H-Index: 11
Last. Ulrich Beuers (UvA: University of Amsterdam)H-Index: 66
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Abstract Background and aims Pruritus may seriously impair quality of life in patients with cholestatic diseases such as primary or secondary sclerosing cholangitis (PSC, SSC) and primary biliary cholangitis (PBC). Pharmacological strategies show limited efficacy and can provoke serious side effects. We hypothesized that bezafibrate, a broad peroxisome proliferator-activated receptor (PPAR) agonist, relieves cholestasis-associated itch by alleviating hepatobiliary injury. The aim of this investi...
8 CitationsSource
#1David C. Trampert (UvA: University of Amsterdam)H-Index: 1
#2Stan F.J. van de Graaf (UvA: University of Amsterdam)H-Index: 28
Last. Ulrich Beuers (UvA: University of Amsterdam)H-Index: 66
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Summary Many epithelia secrete bicarbonate-rich fluid to generate flow, alter viscosity, control pH and potentially protect luminal and intracellular structures from chemical stress. Bicarbonate is a key component of human bile and impaired biliary bicarbonate secretion is associated with liver damage. Major efforts have been undertaken to gain insight into acid-base homeostasis in cholangiocytes and more can be learned from analogous secretory epithelia. Extrahepatic examples include salivary a...
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