Meghana Koneru
Indian Institute of Chemical Technology
Matrix metalloproteinaseCytochrome c oxidaseCaspase 3NephrotoxicityInternal medicineEndocrinologyCYP2E1PathologyGlutathione reductaseChemistryApoptosisMyeloperoxidaseOxidative stressNatural (archaeology)Liver injuryCirrhosisLactate dehydrogenaseNaringinFisetinPotassium dichromateNF-?BAntioxidantBlood urea nitrogenCardiotoxicityCisplatinFatty liverCatalaseNADPH oxidaseI?BaNOX4AvenaVitamin CDrugCapsaicinLipoproteinKidneyEthanolFibrosisCarvedilolLipid peroxidationAlcoholMitochondrionRespiratory enzymeLiver functionAcute liver injuryMyocardial infarctionGlutathioneBiochemistryMedicineBiologyPharmacology
9Publications
6H-index
323Citations
Publications 9
Newest
#1Salma Mukhtar Mir (AcSIR: Academy of Scientific and Innovative Research)H-Index: 2
#2Bidya Dhar Sahu (Indian Institute of Chemical Technology)H-Index: 16
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 8 authors...
Dietary supplementation of oats has been associated with reduced risk of cardiovascular disease, diabetes, and gastrointestinal disorders. The role of oat extract as prophylactic in treating acute liver injury is not thoroughly established. We, therefore, hypothesized that oat extract would exert protective effect against alcohol-induced acute liver injury in a mouse model. To test this hypothesis, male C57BL/6 mice were pretreated with phenolic-enriched ethyl acetate (EA) fraction of oats (prep...
4 CitationsSource
#1Meghana Koneru (Indian Institute of Chemical Technology)H-Index: 6
#2Bidya Dhar Sahu (Indian Institute of Chemical Technology)H-Index: 16
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 8 authors...
Alcohol, the most common cause for hepatic injury, may further deteriorate the hepatic tissue when left unattended. Capsaicin, the pungent principle of chilli peppers, possesses antioxidant and anti-inflammatory properties and is a proven dietary antioxidant in various ailments. However, its role in alcohol-induced hepatic injury is unclear. In this study, we investigated the effects of capsaicin on the hepatic tissue of mice treated with alcohol. Acute liver injury was induced in mice by oral g...
4 CitationsSource
#1Meghana KoneruH-Index: 6
#2Nasiruddin NalbanH-Index: 3
Last. Ramakrishna SistlaH-Index: 1
view all 4 authors...
Source
#1Meghana Koneru (Indian Institute of Chemical Technology)H-Index: 6
#2Bidya Dhar Sahu (Indian Institute of Chemical Technology)H-Index: 16
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 8 authors...
Abstract Background Alcohol, a most commonly consumed beverage, is the foremost cause of liver injury throughout the world. Polydatin, a stilbenoid glucoside, was known to possess antioxidant and anti-inflammatory properties and is being investigated for use in various disorders. Purpose The present study was intended at investigating the hepatoprotective efficacy of polydatin against acute-alcohol induced liver injury model in mice. Study design C57BL/6 mice were fed with five doses of 50% ethy...
23 CitationsSource
#1Meghana Koneru (Indian Institute of Chemical Technology)H-Index: 6
#2Bidya Dhar Sahu (Indian Institute of Chemical Technology)H-Index: 16
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 7 authors...
Abstract Alcohol consumption is an addictive disorder causing hepatic steatosis, fibrosis and cirrhosis. The protective effect of fisetin, a bioflavonoid, present in foods like strawberries, apples, persimmons, grapes and onions was studied on murine model of acute alcohol-induced hepatotoxicity. Five doses of 50% ethanol p.o. (10 ml/kg body weight) every 12 hours was used to induce hepatotoxicity in mice. Liver function, oxidative stress, histological changes, mitochondrial function, pro-inflam...
26 CitationsSource
#1Bidya Dhar Sahu (Indian Institute of Chemical Technology)H-Index: 16
#2Meghana Koneru (Indian Institute of Chemical Technology)H-Index: 6
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 5 authors...
Abstract Nephrotoxicity is a major adverse effect of chromium poisoning. In the present study, we investigated the potential renoprotective effect and underlying mechanisms of carvedilol, a non-specific β-adrenergic blocker using rat model of potassium dichromate-induced nephrotoxicity. Rats were pretreated with carvedilol (10 mg/kg) for 21 days. A single subcutaneous injection of potassium dichromate (15 mg/kg, s.c.) resulted in a significant increase in the levels of blood urea nitrogen and se...
34 CitationsSource
#1Bidya Dhar Sahu (Indian Institute of Chemical Technology)H-Index: 16
#2Anil Kumar KalvalaH-Index: 1
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 7 authors...
Nephrotoxicity is a dose-dependent side effect of cisplatin limiting its clinical usage in the field of cancer chemotherapy. Fisetin is a bioactive flavonoid with recognized antioxidant and anti-inflammatory properties. In the present study, we investigated the potential renoprotective effect and underlying mechanism of fisetin using rat model of cisplatin-induced nephrotoxicity. The elevation in serum biomarkers of renal damage (blood urea nitrogen and creatinine); degree of histopathological a...
105 CitationsSource
#1Bidya Dhar Sahu (Indian Institute of Chemical Technology)H-Index: 16
#2Harika Anubolu (Indian Institute of Chemical Technology)H-Index: 1
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 7 authors...
Abstract Aims Preventive and/or therapeutic interventions using natural products for ischemic heart disease have gained considerable attention worldwide. This study investigated the cardioprotective effect and possible mechanism of embelin, a major constituent of Embelia ribes Burm, using isoproterenol (ISO)-induced myocardial infarction model in rats. Materials and methods Rats were pretreated for three days with embelin (50 mg/kg, p.o) before inducing myocardial injury by administration of ISO...
36 CitationsSource
#1Bidya Dhar Sahu (Indian Institute of Chemical Technology)H-Index: 16
#2Srujana TatireddyH-Index: 1
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 9 authors...
Abstract Gentamicin-induced nephrotoxicity has been well documented, although its underlying mechanisms and preventive strategies remain to be investigated. The present study was designed to investigate the protective effect of naringin, a bioflavonoid, on gentamicin-induced nephrotoxicity and to elucidate the potential mechanism. Serum specific renal function parameters (blood urea nitrogen and creatinine) and histopathology of kidney tissues were evaluated to assess the gentamicin-induced neph...
76 CitationsSource