Alison C. Holloway
McMaster University
OffspringInternal medicineEndocrinologyReceptorFetusChemistryIn uteroAromatasePlacentaTrophoblastPregnancyInsulinNicotineGlucose homeostasisPhysiologyGestationObesityDiabetes mellitusHormoneMedicineBiology
169Publications
48H-index
4,876Citations
Publications 172
Newest
#1Jade Wish (UM: University of Manitoba)
#2Patrique Bulloch (UM: University of Manitoba)H-Index: 2
Last. Gregg T. Tomy (UM: University of Manitoba)H-Index: 42
view all 10 authors...
Abstract null null The aim of this study was to determine the kynurenine (KYN) to tryptophan (TRP) ratio (KTR) in fish tissue to assess its usefulness as a biomarker of acute stress. Laboratory held rainbow trout (Oncorhynchus mykiss) were subjected to an acute stressor and KYN, TRP and cortisol were measured in liver and brain tissues at 4- and 48-h post-stress. The analytical method used to determine our analytes was based on lyophilization, and liquid-solid extraction followed by isotope dilu...
Source
#1Basma A. Ahmed (McMaster University)H-Index: 3
#2Frank J. Ong (McMaster University)H-Index: 3
Last. Norman B. Konyer (St. Joseph's Healthcare Hamilton)H-Index: 10
view all 24 authors...
Summary null null In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and cold-stimulated BAT activity using magnetic resonance imaging and the gut microbiota with 16S sequencing. We transplanted gnotobiotic mice with feces from humans to assess the transferability of BAT activity through the microbiota. Individu...
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#1Sergio Raez-Villanueva (McMaster University)H-Index: 3
#2Genevieve A. Perono (McMaster University)H-Index: 3
Last. Alison C. Holloway (McMaster University)H-Index: 48
view all 5 authors...
Worldwide demand for petroleum products has resulted in increased oil and gas activities in many countries. Conventional and unconventional oil and gas extraction, production, and transport lead to increased levels of petroleum-derived polycyclic aromatic hydrocarbons (PAHs) in the environment. PAH exposure has profound effects on reproduction by affecting pathways involved in placental trophoblast cell function and impairing normal placental development and function-key contributors to reproduc...
Source
#1Bo Wang (McMaster University)H-Index: 1
#2Evangelia Evelyn Tsakiridis (McMaster University)H-Index: 2
Last. James S. V. Lally (McMaster University)H-Index: 14
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Obesity results from a caloric imbalance between energy intake, absorption and expenditure. In both rodents and humans, diet-induced thermogenesis contributes to energy expenditure and involves the activation of brown adipose tissue (BAT). We hypothesize that environmental toxicants commonly used as food additives or pesticides might reduce BAT thermogenesis through suppression of uncoupling protein 1 (UCP1) and this may contribute to the development of obesity. Using a step-wise screening appro...
Source
#1Annia A Martínez-Peña (McMaster University)H-Index: 1
#2Genevieve A. Perono (McMaster University)H-Index: 3
Last. Sandeep Raha (McMaster University)H-Index: 29
view all 9 authors...
Cannabis use during pregnancy has continued to rise, particularly in developed countries, as a result of the trend towards legalization and lack of consistent, evidence-based knowledge on the matter. While there is conflicting data regarding whether cannabis use during pregnancy leads to adverse outcomes such as stillbirth, preterm birth, low birthweight, or increased admission to neonatal intensive care units, investigations into long-term effects on the offspring’s health are limited. Historic...
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#1Matthew J. Meier (Health Canada)H-Index: 7
#2Kathy C. Nguyen (Health Canada)H-Index: 10
Last. L.A. BeaudetteH-Index: 10
view all 13 authors...
Source
#1Sergio Raez-Villanueva (McMaster University)H-Index: 3
#2Amrita Debnath (McMaster University)H-Index: 1
Last. Alison C. Holloway (McMaster University)H-Index: 48
view all 4 authors...
Prenatal exposure to nicotine, tobacco's major addictive constituent, has been shown to reduce birth weight and increases apoptosis, oxidative stress, and mitochondrial dysfunction in the postnatal pancreas. Given that upregulated levels of the pro-oxidative adapter protein p66shc is observed in growth-restricted offspring and is linked to beta-cell apoptosis, the goal of this study was to investigate whether alterations in p66shc expression underlie the pancreatic deficits in nicotine-exposed o...
Source
#1Laiba Jamshed (McMaster University)H-Index: 2
#2Genevieve A. Perono (McMaster University)H-Index: 3
Last. Alison C. Holloway (McMaster University)H-Index: 48
view all 6 authors...
Source
#1Evangelia Evelyn Tsakiridis (McMaster University)H-Index: 2
#2Marisa R Morrow (McMaster University)H-Index: 2
Last. Gregory R. Steinberg (McMaster University)H-Index: 83
view all 7 authors...
Source
#1Bo Wang (McMaster University)H-Index: 1
#2Shuman Zhang (McMaster University)
Last. Gregory R. Steinberg (McMaster University)H-Index: 83
view all 19 authors...
Source
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