Levi P. Sowers
Roy J. and Lucille A. Carver College of Medicine
PathophysiologyGeneNeuropeptideInternal medicinePhenotypeEndocrinologyHippocampal formationCalcitonin gene-related peptideNeuroscienceReceptorAutismEpilepsyMigraineOpen fieldCalcitoninPhotophobiaAnesthesiaMutationGeneticsMedicineMissense mutationBiologyPharmacology
26Publications
10H-index
746Citations
Publications 25
Newest
#1Brandon J. Rea (Roy J. and Lucille A. Carver College of Medicine)H-Index: 4
#2Levi P. Sowers (Roy J. and Lucille A. Carver College of Medicine)H-Index: 10
Last. Andrew F. Russo (Roy J. and Lucille A. Carver College of Medicine)H-Index: 46
view all 8 authors...
We developed an automated squint assay using both black C57BL/6J and white CD1 mice that measured the interpalpebral fissure area between the upper and lower eyelids as an objective quantification of pain. In C57BL/6J mice, we observed a squint response to increasing doses of a migraine trigger, the neuropeptide CGRP, including a significant response in female mice at a dose below detection by the manual grimace scale. Using the automated software, both C57BL/6J and CD1 mice lacked a detectable ...
1 CitationsSource
#1Adisa KuburasH-Index: 12
#2Bianca N. MasonH-Index: 4
Last. Andrew F. RussoH-Index: 46
view all 9 authors...
The neuropeptides CGRP and PACAP have emerged as mediators of migraine, yet the potential overlap of their mechanisms remains unknown. Infusion of PACAP, like CGRP, can cause migraine in people, and both peptides share similar vasodilatory and nociceptive functions. In this study, we have used light aversion in mice as a surrogate for migraine-like photophobia to compare CGRP and PACAP and ask whether CGRP or PACAP actions were dependent on each other. Similar to CGRP, PACAP induced light aversi...
1 CitationsSource
#2William C. Castonguay (UI: University of Iowa)
Last. Andrew F. RussoH-Index: 46
view all 12 authors...
ABSTRACT Chronic complications of traumatic brain injury represent one of the greatest financial burdens and sources of suffering in the society today. A substantial number of these patients suffer from posttraumatic headache (PTH), which is typically associated with tactile allodynia. Unfortunately, this phenomenon has been understudied, in large part because of the lack of well-characterized laboratory animal models. We have addressed this gap in the field by characterizing the tactile sensory...
3 CitationsSource
#1Hashmat Ghanizada (UCPH: University of Copenhagen)H-Index: 6
#2Mohammad Al-Mahdi Al-Karagholi (UCPH: University of Copenhagen)H-Index: 7
Last. Messoud Ashina (UCPH: University of Copenhagen)H-Index: 65
view all 20 authors...
Objective Migraine is a prevalent and disabling neurological disease. Its genesis is poorly understood and there remains unmet clinical need. We aimed to identify mechanisms and thus novel therapeutic targets for migraine using human models of migraine and translational models in animals, with emphasis on amylin, a close relative of calcitonin gene-related peptide (CGRP). Methods Thirty-six migraine without aura patients were enrolled in a randomized, double-blinded, two-way, cross-over, positiv...
1 CitationsSource
#1Levi P. Sowers (UI: University of Iowa)H-Index: 10
#2Mengya Wang (UI: University of Iowa)H-Index: 2
Last. Andrew F. RussoH-Index: 46
view all 10 authors...
OBJECTIVE A hallmark of migraine is photophobia. In mice, photophobia-like behavior is induced by calcitonin gene-related peptide (CGRP), a neuropeptide known to be a key player in migraine. In this study, we sought to identify sites within the brain from which CGRP could induce photophobia. DESIGN We focused on the posterior thalamic region, which contains neurons responsive to both light and dural stimulation and has CGRP binding sites. We probed this area with both optogenetic stimulation and...
2 CitationsSource
#1Anne-Sophie Wattiez (UI: University of Iowa)H-Index: 6
#2Sarah A. O'Shea (UI: University of Iowa)H-Index: 2
Last. Deema Fattal (UI: University of Iowa)H-Index: 1
view all 7 authors...
OBJECTIVE To determine whether patients with vestibular migraine are more likely to suffer from an occipital headache than patients with migraine without vestibular symptoms. BACKGROUND Vestibular migraine is an underdiagnosed disorder in which migraine is associated with vestibular symptoms. Anatomical evidence and symptomatology hint at the involvement of brain structures in the posterior fossa (back of the head location). We hypothesized that vestibular migraine patients are more likely than ...
1 CitationsSource
#1Adisa Kuburas (UI: University of Iowa)H-Index: 12
#2Bianca N. Mason (UI: University of Iowa)H-Index: 4
Last. Andrew F. Russo (UI: University of Iowa)H-Index: 46
view all 8 authors...
Abstract The neuropeptides CGRP and PACAP have emerged as mediators of migraine, yet the potential overlap of their mechanisms remains unknown. Infusion of PACAP, like CGRP, can cause migraine in people, and both peptides share similar vasodilatory and nociceptive functions. In this study, we have used light aversion in mice as a surrogate for migraine-like photophobia to compare CGRP and PACAP and ask whether CGRP or PACAP actions were dependent on each other. Similar to CGRP, PACAP induced lig...
Source
#1Anne-Sophie Wattiez (UI: University of Iowa)H-Index: 6
#1Anne-Sophie Wattiez (UI: University of Iowa)H-Index: 1
Last. Andrew F Russo (UI: University of Iowa)H-Index: 1
view all 12 authors...
Chronic complications of traumatic brain injury (TBI) represent one of the greatest financial burdens and sources of suffering in society today. A substantial number of these patients suffer from post-traumatic headache (PTH), which is typically associated with tactile allodynia. Unfortunately, this phenomenon has been under-studied, in large part due to the lack of well-characterized laboratory animal models. We have addressed this gap in the field by characterizing the tactile sensory profile ...
Source
#1Anne-Sophie Wattiez (UI: University of Iowa)H-Index: 6
#2Levi P. Sowers (UI: University of Iowa)H-Index: 10
Last. Andrew F. Russo (UI: University of Iowa)H-Index: 46
view all 3 authors...
ABSTRACTIntroduction: The neuropeptide calcitonin gene-related peptide (CGRP) is recognized as a critical player in migraine pathophysiology. Excitement has grown regarding CGRP because of the deve...
7 CitationsSource
#1Brandon J. Rea (Roy J. and Lucille A. Carver College of Medicine)H-Index: 4
#1Brandon J Rea (Roy J. and Lucille A. Carver College of Medicine)H-Index: 1
Last. Andrew F. Russo (Roy J. and Lucille A. Carver College of Medicine)H-Index: 4
view all 16 authors...
Migraine is the third most common disease in the world (behind dental caries and tension-type headache) with an estimated global prevalence of 15%, yet its etiology remains poorly understood. Recent clinical trials have heralded the potential of therapeutic antibodies that block the actions of the neuropeptide calcitonin gene–related peptide (CGRP) or its receptor to prevent migraine. Calcitonin gene–related peptide is believed to contribute to trigeminal nerve hypersensitivity and photosensitiv...
29 CitationsSource