Gabriella M. Composto
Rutgers University
AnatomyProdrugInternal medicineEndocrinologyPathologyDNA damageAbsorption (skin)Cannabinoid receptorMolecular biologyProinflammatory cytokineChemistryPeroxisome proliferator-activated receptorSkin repairImmunologyInflammationKeratinocyteHair follicleNitric oxide synthaseDermisInfiltration (medical)Nitrogen mustardMethylamineErythemaHairlessAnti-inflammatoryAnandamideWound healingBifunctionalSulfideSulfur mustardFatty acid amide hydrolaseFollicular CystCell DegranulationEpithelial DamagePoison controlMouse skinSkin damageEndocannabinoid systemDegranulationNecrosisNitric oxideBiochemistryMedicineKaryolysisBiologyEpidermis (botany)Pharmacology
9Publications
5H-index
38Citations
Publications 9
Newest
#1Laurie B. Joseph (RU: Rutgers University)H-Index: 12
#2Gabriella M. Composto (RU: Rutgers University)H-Index: 5
Last. Diane E. Heck (NYMC: New York Medical College)H-Index: 4
view all 13 authors...
Abstract Sulfur mustard (SM, bis(2-chloroethyl sulfide) is a potent vesicating agent known to cause skin inflammation, necrosis and blistering. Evidence suggests that inflammatory cells and mediators that they generate are important in the pathogenic responses to SM. In the present studies we investigated the role of mast cells in SM-induced skin injury using a murine vapor cup exposure model. Mast cells, identified by toluidine blue staining, were localized in the dermis, adjacent to dermal app...
9 CitationsSource
#1Irene M. Wohlman (RU: Rutgers University)H-Index: 3
#2Gabriella M. Composto (RU: Rutgers University)H-Index: 5
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
view all 12 authors...
Vesicants including sulfur mustard (SM) and nitrogen mustard (NM) are bifunctional alkylating agents that cause skin inflammation, edema and blistering. This is associated with alterations in keratinocyte growth and differentiation. Endogenous cannabinoids, including N-arachidonoylethanolamine (anandamide, AEA) and 2-arachidonoyl glycerol (2-AG), are important in regulating inflammation, keratinocyte proliferation and wound healing. Their activity is mediated by binding to cannabinoid receptors ...
8 CitationsSource
#1Laurie B. Joseph (RU: Rutgers University)H-Index: 12
#2Gabriella M. Composto (RU: Rutgers University)H-Index: 5
Last. Diane E. Heck (NYMC: New York Medical College)H-Index: 38
view all 3 authors...
In mouse skin, sulfur mustard (SM) is a potent vesicant, damaging both the epidermis and the dermis. The extent of wounding is dependent on the dose of SM and the duration of exposure. Initial responses include erythema, pruritus, edema, and xerosis; this is followed by an accumulation of inflammatory leukocytes in the tissue, activation of mast cells, and the release of mediators, including proinflammatory cytokines and bioactive lipids. These proinflammatory mediators contribute to damaging th...
5 CitationsSource
#1Gabriella M. Composto (RU: Rutgers University)H-Index: 5
#2Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
Last. Diane E. Heck (NYMC: New York Medical College)H-Index: 4
view all 8 authors...
Abstract Nitrogen mustard (NM) is a bifunctional alkylating agent that is highly reactive in the skin causing extensive tissue damage and blistering. In the present studies, a modified cutaneous murine patch model was developed to characterize NM-induced injury and to evaluate the efficacy of an indomethacin pro-drug in mitigating toxicity. NM (20 μmol) or vehicle control was applied onto 6 mm glass microfiber filters affixed to the shaved dorsal skin of CD-1 mice for 6 min. This resulted in abs...
10 CitationsSource
#1Diane E. HeckH-Index: 38
#2Irene M. WohlmanH-Index: 3
Last. Jeffrey D. LaskinH-Index: 69
view all 9 authors...
Vesicants including sulfur mustard (SM, bis(2-chloroethyl) sulfide) and nitrogen mustard (NM, bis(2-chloroethyl)methylamine) are highly reactive bifunctional alkylating agents that target the skin....
#1Gabriella M. Composto (RU: Rutgers University)H-Index: 5
#2Sally Kim (RU: Rutgers University)
Last. Laurie B. Joseph (RU: Rutgers University)H-Index: 12
view all 6 authors...
Source
#1Sally Kim (RU: Rutgers University)
#2Gabriella M. Composto (RU: Rutgers University)H-Index: 5
Last. Debra L. Laskin (RU: Rutgers University)H-Index: 71
view all 9 authors...
Sulfur mustard (SM) is a chemical warfare agent that causes skin damage characterized by inflammation and blistering. We investigated leukocyte infiltration into mouse skin after SM exposure. The d...
Source
#1Laurie B. Joseph (RU: Rutgers University)H-Index: 12
#2Diane E. Heck (NYMC: New York Medical College)H-Index: 38
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
view all 10 authors...
Abstract Sulfur mustard (SM) is a bifunctional alkylating agent causing skin inflammation, edema and blistering. A hallmark of SM-induced toxicity is follicular and interfollicular epithelial damage. In the present studies we determined if SM-induced structural alterations in hair follicles and sebaceous glands were correlated with cell damage, inflammation and wound healing. The dorsal skin of hairless mice was treated with saturated SM vapor. One to seven days later, epithelial cell karyolysis...
10 CitationsSource
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