Yogesh K. Vashist
University of Hamburg
Genome-wide association studyCancerInternal medicineGenotypeSurgeryPathologyOncologySingle-nucleotide polymorphismAlleleCarcinomaEsophageal cancerBone marrowPancreatic cancerAdenocarcinomaPerioperativeCancer researchGeneticsMedicineBiologyGastroenterology
Publications 163
#2Savio G. BarretoH-Index: 22
Last. Christopher L. WolfgangH-Index: 102
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Objective null The ISGPS aimed to develop a universally accepted definition for PPAP for standardized reporting and outcome comparison. null Background null PPAP is an increasingly recognized complication after partial pancreatic resections, but its incidence and clinical impact, and even its existence are variable because an internationally accepted consensus definition and grading system are lacking. null Methods null The ISGPS developed a consensus definition and grading of PPAP with its memb...
#1Ye Lu (DKFZ: German Cancer Research Center)
#5George Theodoropoulos (UoA: National and Kapodistrian University of Athens)H-Index: 31
Last. Jakob R. Izbicki (UHH: University of Hamburg)H-Index: 75
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#1Laura Pistoni (UniPi: University of Pisa)H-Index: 1
#2Manuel Gentiluomo (UniPi: University of Pisa)H-Index: 6
Last. Yogesh K. Vashist (UHH: University of Hamburg)H-Index: 27
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Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Its poor prognosis is predominantly due to the fact that most patients remain asymptomatic until the disease reaches an advanced stage, alongside the lack of early markers and screening strategies. A better understanding of PDAC risk factors is essential for the identification of groups at high risk in the population. Genome-wide association studies (GWAS) have been a powerful tool for detecting genetic variants associated...
#2Manuel Gentiluomo (UniPi: University of Pisa)H-Index: 6
Last. Daniele Campa (UniPi: University of Pisa)H-Index: 34
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Background Most cases of pancreatic ductal adenocarcinoma (PDAC) are asymptomatic in early stages, and the disease is typically diagnosed in advanced phases, resulting in very high mortality. Tools to identify individuals at high risk of developing PDAC would be useful to improve chances of early detection. Objective We generated a polygenic risk score (PRS) for PDAC risk prediction, combining the effect of known risk SNPs, and carried out an exploratory analysis of a multifactorial score. Metho...
7 CitationsSource
#1Shruti G DigheH-Index: 1
#2Jianhong Chen (Roswell Park Cancer Institute)H-Index: 2
Last. Matthew F. BuasH-Index: 14
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Genome-wide association studies (GWAS) of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE), have uncovered significant genetic components of risk, but most heritability remains unexplained. Targeted assessment of genetic variation in biologically relevant pathways using novel analytical approaches may identify missed susceptibility signals. Central obesity, a key BE/EAC risk factor, is linked to systemic inflammation, altered hormonal signaling, and insulin-like growth...
3 CitationsSource
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability has been unexplored so far. Combining genome wide association studies and functional data, we inves...
3 CitationsSource
#1Jing Dong (BCM: Baylor College of Medicine)H-Index: 30
#2Carlo Maj (University of Bonn)H-Index: 9
Last. Aaron P. Thrift (BCM: Baylor College of Medicine)H-Index: 28
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Background & aims Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence of up to 6:1). Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for these conditions. However, potential sex differences in genetic associations with BE/EA remain largely unexplored. Methods Given strong genetic overlap, BE and EA cases were co...
2 CitationsSource
#1Louisa BolmH-Index: 10
Last. Ulrich F. WellnerH-Index: 30
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