Wilfrid Rall
National Institutes of Health
Voltage clampPhysicsSynapseMathematical analysisVoltageNeuroscienceDendritic spineMembrane potentialElectrophysiologyChemistryBiological neuron modelNeuronSomaDendriteDepolarizationMembraneDendritic filopodiaTime constantTransient responseBiology
Publications 29
#1Wilfrid Rall (NIH: National Institutes of Health)H-Index: 23
The sections in this article are: 1 Introduction 1.1 Core Conductor Concept 1.2 Perspective 1.3 Comment 1.4 Reviews and Monographs 2 Brief Historical Notes 2.1 Early Electrophysiology 2.2 Electrotonus 2.3 Passive Membrane Electrotonus 2.4 Passive Versus Active Membrane 2.5 Cable Theory 2.6 Core Conductor Concept 2.7 Core Conductor Theory 2.8 Estimation of Membrane Capacitance 2.9 Resting Membrane Resistivitiy 2.10 Passive Cable Parameters of Invertebrate Axons 2.11 Importance of Single Axon Prep...
154 CitationsSource
#1Wilfrid Rall (NIH: National Institutes of Health)H-Index: 23
An installation for the multiplexed transmission of signals from seismic receivers, each associated with a respective multiplexing circuit, connected in series in a transmission line between a generator of first pulse signals and a registration station. Each receiver is followed by a digitiser and each multiplexing circuit includes means allowing the first pulse signals to pass without modification, at least one shift register, capable of being filled with digital information from the associated...
623 CitationsSource
#1Idan Segev (HUJI: Hebrew University of Jerusalem)H-Index: 53
#2Wilfrid Rall (NIH: National Institutes of Health)H-Index: 23
Abstract Important advances in experimental methods have made it possible to measure the electrical events in dendrites directly and to record optically from dendritic spines. These new techniques allow us to focus on the input region of the neuron and highlight the excitable properties of the dendritic membrane. Interestingly, some of the recent experimental findings were anticipated by earlier theoretical research, for example, the observation that some spines possess excitable channels that m...
159 CitationsSource
#1William R. HolmesH-Index: 13
#2Wilfrid RallH-Index: 23
3 Citations
#1Wilfrid RallH-Index: 23
#2Idan SegevH-Index: 53
5 Citations
#1Wilfrid Rall (NIH: National Institutes of Health)H-Index: 23
5 CitationsSource
#1W. R. Holmes (NIH: National Institutes of Health)H-Index: 4
#2Idan SegevH-Index: 53
Last. Wilfrid RallH-Index: 23
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1. We have investigated the theoretical and practical problems associated with the interpretation of time constants and the estimation of electrotonic length with equivalent cylinder formulas for neurons best represented as multiple cylinders or branched structures. Two analytic methods were used to compute the time constants and coefficients of passive voltage transients (and time constants of current transients under voltage clamp). One method, suitable for simple geometries, involves analytic...
65 CitationsSource
#1Wilfrid Rall (NIH: National Institutes of Health)H-Index: 23
#2R. E. BurkeH-Index: 1
Last. Idan SegevH-Index: 53
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260 CitationsSource
#1William R. Holmes (OU: Ohio University)H-Index: 13
#2Wilfrid Rall (NIH: National Institutes of Health)H-Index: 23
Publisher Summary This chapter focuses on different electrotonic models of neuronal dendrites and single neuron computation to reduce the number degrees of freedom. The areas that help in reducing the degrees of freedom include the importance for modeling studies of having good estimates of the electrotonic structure of a cell, the dynamic range of computational possibilities available to a neuron, by considering its possible resting states, assuming that a real neuron ever can be considered to ...
22 CitationsSource
#1Wilfrid Rall (NIH: National Institutes of Health)H-Index: 23
This talk briefly reviewed results of earlier computations that simulated synaptic inputs to passive dendritic membrane. Then it reviewed dendritic spines and the possibility that some spine heads might have excitable membrane properties. Because some neurons have dendritic arbors that are studded with hundreds or thousands of spines, computations were used to explore theoretical examples of different synaptic input combinations to both excitable and passive spines. The results demonstrate the p...
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