Thomas Benner
Harvard University
AnatomyPhysicsInternal medicinePathologyMagnetic resonance imagingDiffusion MRIArtificial intelligencePsychologyNeuroscienceMultiple sclerosisWhite matterNuclear medicineComputer visionComputer scienceNuclear magnetic resonanceStrokeVoxelMedicineTractographyFractional anisotropy
Publications 69
#1Songlin DingH-Index: 31
#2Joshua J. RoyallH-Index: 10
Last. Ed S. LeinH-Index: 45
view all 40 authors...
#1Songlin Ding (Allen Institute for Artificial Intelligence)H-Index: 31
#2Joshua J. Royall (Allen Institute for Artificial Intelligence)H-Index: 10
Last. Tim A. Dolbeare (Allen Institute for Artificial Intelligence)H-Index: 13
view all 40 authors...
Detailed anatomical understanding of the human brain is essential for unraveling its functional architecture, yet current reference atlases have major limitations such as lack of whole-brain coverage, relatively low image resolution, and sparse structural annotation. We present the first digital human brain atlas to incorporate neuroimaging, high-resolution histology, and chemoarchitecture across a complete adult female brain, consisting of magnetic resonance imaging (MRI), diffusion-weighted im...
#1Audrey P. Fan (Harvard University)H-Index: 20
#2Sindhuja T. Govindarajan (Harvard University)H-Index: 12
Last. Caterina Mainero (Harvard University)H-Index: 37
view all 10 authors...
Quantitative oxygen extraction fraction (OEF) in cortical veins was studied in patients with multiple sclerosis (MS) and healthy subjects via magnetic resonance imaging (MRI) phase images at 7 Tesla (7 T). Flow-compensated, three-dimensional gradient-echo scans were acquired for absolute OEF quantification in 23 patients with MS and 14 age-matched controls. In patients, we collected T2*-weighted images for characterization of white matter, deep gray matter, and cortical lesions, and also assesse...
#1Hakan Ay (Harvard University)H-Index: 59
#2Ethem Murat Arsava (Harvard University)H-Index: 22
Last. James F. Meschia (Mayo Clinic)H-Index: 76
view all 54 authors...
NINDS (National Institute of Neurological Disorders and Stroke)-SiGN (Stroke Genetics Network) is an international consortium of ischemic stroke studies that aims to generate high-quality phenotype data to identify the genetic basis of pathogenic stroke subtypes. This analysis characterizes the etiopathogenetic basis of ischemic stroke and reliability of stroke classification in the consortium.
#1Jean C. Augustinack (Harvard University)H-Index: 33
#2Andre van der Kouwe (Harvard University)H-Index: 44
Last. Suzanne Corkin (MIT: Massachusetts Institute of Technology)H-Index: 8
view all 9 authors...
H.M., Henry Molaison, was one of the world's most famous amnesic patients. His amnesia was caused by an experimental brain operation, bilateral medial temporal lobe resection, carried out in 1953 to relieve intractable epilepsy. He died on December 2, 2008, and that night we conducted a wide variety of in situ MRI scans in a 3 T scanner at the Massachusetts General Hospital (Mass General) Athi- noula A. Martinos Center for Biomedical Imaging. For the in situ experi- ments, we acquired a full set...
#1Kyoko Fujimoto (Harvard University)H-Index: 9
#2Jonathan R. Polimeni (Harvard University)H-Index: 50
Last. Lawrence L. Wald (MIT: Massachusetts Institute of Technology)H-Index: 84
view all 8 authors...
Abstract The Magnetization-Prepared 2 Rapid Acquisition Gradient Echo (MP2RAGE) method achieves spatially uniform contrast across the entire brain between gray matter and surrounding white matter tissue and cerebrospinal fluid by rapidly acquiring data at two points during an inversion recovery, and then combining the two volumes so as to cancel out sources of intensity and contrast bias, making it useful for neuroimaging studies at ultrahigh field strengths (≥ 7 T). To quantify the effectivenes...
#1James Kolasinski (Harvard University)H-Index: 10
#2Emi Takahashi (Harvard University)H-Index: 22
Last. P. Ellen Grant (Harvard University)H-Index: 54
view all 7 authors...
Corticogenesis is underpinned by a complex process of subcortical neuroproliferation, followed by highly orchestrated cellular migration. A greater appreciation of the processes involved in human fetal corticogenesis is vital to gaining an understanding of how developmental disturbances originating in gestation could establish a variety of complex neuropathology manifesting in childhood, or even in adult life. Magnetic resonance imaging modalities offer a unique insight into anatomical structure...
#1A. Scott Nielsen (Virginia Mason Medical Center)H-Index: 8
#2Revere P. KinkelH-Index: 13
Last. Caterina MaineroH-Index: 37
view all 6 authors...
Objectives: Evaluate cross-sectionally the contribution of focal cortical lesion (CL) subtypes at ultra-high-field MRI and traditional MRI metrics of brain damage to neurologic disability and cognitive performance in a heterogeneous multiple sclerosis (MS) cohort. Methods: Thirty-four patients with early or established disease including clinically isolated syndrome, relapsing-remitting MS, and secondary progressive MS were scanned on a human 7-tesla (7T) (Siemens) scanner to acquire fast low-ang...
#1Brian L. Edlow (Harvard University)H-Index: 30
#2Robin L. Haynes (Boston Children's Hospital)H-Index: 28
Last. Rebecca D. Folkerth (Brigham and Women's Hospital)H-Index: 56
view all 11 authors...
Traumatic coma is associated with disruption of axonal pathways throughout the brain but the specific pathways involved in humans are incompletely understood. In this study, we used high angular resolution diffusion imaging (HARDI) to map the connectivity of axonal pathways that mediate the 2 critical components of consciousness – arousal and awareness – in the postmortem brain of a 62-year-old woman with acute traumatic coma and in 2 control brains. HARDI tractography guided tissue sampling in ...
#1Ona WuH-Index: 57
#2William A. CopenH-Index: 25
Last. Aneesh B. SinghalH-Index: 64
view all 9 authors...
Background: Increases in oxygen extraction fraction (OEF) are postulated to be a marker of tissue at risk of infarction in acute ischemic stroke patients. R2’, a parameter that can be measured rapi...
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