Emiri T. Mandeville
Harvard University
OpticsBiomedical engineeringPathologyBlood flowNeuroscienceMaterials scienceNeuroprotectionIntracerebral hemorrhageBlood–brain barrierOptical coherence tomographyBrain ischemiaPreclinical imagingAnesthesiaTwo-photon excitation microscopyStrokeIschemiaNeuroimagingMedicineCell biologyPharmacology
50Publications
20H-index
1,600Citations
Publications 50
Newest
#1Eng H. Lo (Harvard University)H-Index: 89
#2Gregory A Albers (Stanford University)
Last. Alastair M. Buchan (University of Oxford)
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Circadian biology modulates almost all aspects of mammalian physiology, disease, and response to therapies. Emerging data suggest that circadian biology may significantly affect the mechanisms of susceptibility, injury, recovery, and the response to therapy in stroke. In this review/perspective, we survey the accumulating literature and attempt to connect molecular, cellular, and physiological pathways in circadian biology to clinical consequences in stroke. Accounting for the complex and multif...
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#1Akihiro Shindo (Harvard University)H-Index: 12
#2Hajime Takase (Harvard University)H-Index: 12
Last. Ken Arai (Harvard University)H-Index: 45
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Recent clinical studies suggest that pentraxin 3 (PTX3), which is known as an acute-phase protein that is produced rapidly at local sites of inflammation, may be a new biomarker of disease risk for central nervous system disorders, including stroke. However, the effects of PTX3 on cerebrovascular function in the neurovascular unit (NVU) after stroke are mostly unknown, and the basic research regarding the roles of PTX3 in NVU function is still limited. In this reverse translational study, we pre...
2 CitationsSource
#1Ji Hae Seo (Harvard University)H-Index: 25
#2Takakuni Maki (Harvard University)H-Index: 24
Last. Ken Arai (Harvard University)H-Index: 45
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#1Wenjun Deng (Harvard University)H-Index: 13
#2Emiri T. Mandeville (Harvard University)H-Index: 20
Last. Changhong Xing (Harvard University)H-Index: 27
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Microglia are key regulators of inflammatory response after stroke and brain injury. To better understand activation of microglia as well as their phenotypic diversity after ischemic stroke, we pro...
1 CitationsSource
#1Elga Esposito (Harvard University)H-Index: 16
#2Wenlu Li (Harvard University)H-Index: 10
Last. Eng H. Lo (Harvard University)H-Index: 89
view all 13 authors...
1 CitationsSource
#1Elga Esposito (Harvard University)H-Index: 16
#2Wenlu Li (Harvard University)H-Index: 10
Last. Eng H. Lo (Harvard University)H-Index: 89
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Neuroprotectant strategies that have worked in rodent models of stroke have failed to provide protection in clinical trials. Here we show that the opposite circadian cycles in nocturnal rodents versus diurnal humans1,2 may contribute to this failure in translation. We tested three independent neuroprotective approaches—normobaric hyperoxia, the free radical scavenger α-phenyl-butyl-tert-nitrone (αPBN), and the N-methyl-d-aspartic acid (NMDA) antagonist MK801—in mouse and rat models of focal cere...
8 CitationsSource
#1Teck Chuan Lim (MIT: Massachusetts Institute of Technology)H-Index: 9
#2Emiri T. Mandeville (Harvard University)H-Index: 20
Last. Myron Spector (Brigham and Women's Hospital)H-Index: 67
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We assessed an injectable gelatin hydrogel containing epidermal growth factor (Gtn-EGF) as a therapy for intracerebral hemorrhage (ICH). ICH was induced in rats via collagenase injection into the striatum. Two weeks later, Gtn-EGF was injected into the cavitary lesion. The hydrogel filled ICH cavities without deforming brain tissue. Immunostaining demonstrated that neural precursor cells could migrate into the matrix, and some of these differentiated into neurons along with the appearance of ast...
6 CitationsSource
#1Elga Esposito (Harvard University)H-Index: 16
#2Bum Ju Ahn (Harvard University)H-Index: 12
Last. Kazuhide Hayakawa (Harvard University)H-Index: 34
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After stroke, peripheral immune cells are activated and these systemic responses may amplify brain damage, but how the injured brain sends out signals to trigger systemic inflammation remains unclear. Here we show that a brain-to-cervical lymph node (CLN) pathway is involved. In rats subjected to focal cerebral ischemia, lymphatic endothelial cells proliferate and macrophages are rapidly activated in CLNs within 24 h, in part via VEGF-C/VEGFR3 signalling. Microarray analyses of isolated lymphati...
16 CitationsSource
#1Kazuhide Hayakawa (Harvard University)H-Index: 34
#2Su Jing Chan (Harvard University)H-Index: 11
Last. Eng H. Lo (Harvard University)H-Index: 89
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: Endothelial progenitor cells (EPCs) have been pursued as a potential cellular therapy for stroke and central nervous system injury. However, their underlying mechanisms remain to be fully defined. Recent experimental studies suggest that mitochondria may be released and transferred between cells. In this proof-of-concept study, we asked whether beneficial effects of EPCs may partly involve a mitochondrial phenomenon as well. First, EPC-derived conditioned medium was collected and divided into ...
40 CitationsSource
#1Clarissa Zimmerman Cooley (Harvard University)H-Index: 7
#2Joseph B. Mandeville (Harvard University)H-Index: 40
Last. Lawrence L. Wald (MIT: Massachusetts Institute of Technology)H-Index: 71
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Abstract Magnetic Particle Imaging (MPI) is a rapidly developing imaging modality that directly measures and maps the concentration of injected superparamagnetic iron oxide nanoparticles (SPIOs). Since the agent does not cross the blood-brain barrier, cerebral SPIO concentration provides a direct probe of Cerebral Blood Volume (CBV). Here we provide an initial demonstration of the ability of MPI to detect functional CBV changes (fCBV) by monitoring SPIO concentration during hypercapnic manipulat...
13 CitationsSource