Silvio Aime
University of Turin
Analytical chemistryParamagnetismBiophysicsMagnetic resonance imagingMedicinal chemistryInorganic chemistryChemistryChelationLanthanideIn vivoMoietyMoleculeRelaxation (NMR)Nuclear magnetic resonanceGadoliniumNuclear magnetic resonance spectroscopyStereochemistryMedicineCrystallographyLigand
781Publications
91H-index
23.1kCitations
Publications 765
Newest
#1Lorenzo Palagi (UNITO: University of Turin)H-Index: 1
#2Enza Di Gregorio (UNITO: University of Turin)H-Index: 16
Last. Eliana Gianolio (UNITO: University of Turin)H-Index: 34
view all 8 authors...
The search for alternatives to Gd-containing magnetic resonance imaging (MRI) contrast agents addresses the field of Fe(III)-bearing species with the expectation that the use of an essential metal ion may avoid the issues raised by the exogenous Gd. Attention is currently devoted to highly stable Fe(III) complexes with hexacoordinating ligands, although they may lack any coordinated water molecule. We found that the hexacoordinated Fe(III) complex with two units of deferasirox, a largely used ir...
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#1Annasofia Anemone (UNITO: University of Turin)H-Index: 6
#2Martina Capozza (UNITO: University of Turin)H-Index: 4
Last. Silvio Aime (UNITO: University of Turin)H-Index: 91
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D-Glucose and 3-O-Methyl-D-glucose (3OMG) have been shown to provide contrast in magnetic resonance imaging-chemical exchange saturation transfer (MRI-CEST) images. However, a systematic comparison between these two molecules has yet to be performed. The current study deals with the assessment of the effect of pH, saturation power level (B1 ) and magnetic field strength (B0 ) on the MRI-CEST contrast with the aim of comparing the in vivo CEST contrast detectability of these two agents in the glu...
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#1Valeria Bitonto (UNITO: University of Turin)H-Index: 6
#2Maria Rosaria Ruggiero (UNITO: University of Turin)H-Index: 5
Last. Simonetta Geninatti Crich (UNITO: University of Turin)H-Index: 29
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As conserving surgery is routinely applied for the treatment of early-stage breast cancer, the need for new technology to improve intraoperative margin assessment has become increasingly important. In this study, the potential of fast field-cycling 1H-NMR relaxometry as a new diagnostic tool was evaluated. The technique allows the determination of the tissue proton relaxation rates (R1), as a function of the applied magnetic field, which are affected by the changes in the composition of the mamm...
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#1Martina Capozza (UNITO: University of Turin)H-Index: 4
#2Annasofia Anemone (UNITO: University of Turin)H-Index: 6
Last. Silvio Aime (UNITO: University of Turin)H-Index: 91
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Purpose null Triple-negative breast cancer (TNBC) patients have usually poor outcome after chemotherapy and early prediction of therapeutic response would be helpful. [18F]F-FDG-PET/CT acquisitions are often carried out to monitor variation in metabolic activity associated with response to the therapy, despite moderate accuracy and radiation exposure limit its application. The glucoCEST technique relies on the use of unlabelled D-glucose to assess glucose uptake with conventional MRI scanners an...
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#1Oksana BondarH-Index: 1
#2Eleonora CavallariH-Index: 9
Last. Francesca Reineri (UNITO: University of Turin)H-Index: 19
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ParaHydrogen Induced Polarization-Side Arm Hydrogenation (PHIP-SAH) is an inexpensive tool to obtain hyperpolarized pyruvate (and other metabolites) that can be applied to in-vivo diagnostics, for the investigation of metabolic processes. This method is based on hydrogenation, using hydrogen enriched in the para-isomer, of unsaturated substrates, catalyzed, usually, by a homogeneous rhodium(I) complex. In this work, the effect of the solvent on the hydrogenation efficiency and on the hyperpolari...
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#1Chiara Furlan (UNITO: University of Turin)H-Index: 2
#2Francesca Montarolo (UNITO: University of Turin)H-Index: 13
Last. Eliana Gianolio (UNITO: University of Turin)H-Index: 34
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Abstract null null Objectives null The aim of this study is to quantitatively investigate, at the preclinical level, the extent of Gd retention in the CNS, and peripheral organs, of immune-mediated murine models (Experimental Autoimmune Encephalomyelitis –EAE) of Multiple Sclerosis, compared to control animals, upon the injection of gadodiamide. The influence of the Gadolinium Based Contrast Agent administration timing during the course of EAE development is also monitored. null null null Method...
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#1Enza Di Gregorio (UNITO: University of Turin)H-Index: 16
#2Valeria Bitonto (UNITO: University of Turin)H-Index: 6
Last. Simonetta Geninatti Crich (UNITO: University of Turin)H-Index: 29
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This study is focused on the development of innovative sensors to non-invasively monitor the tissue implant status by Fast-Field-Cycling Magnetic Resonance Imaging (FFC-MRI). These sensors are based on oligo-histidine moieties that are conjugated to PLGA polymers representing the structural matrix for cells hosting scaffolds. The presence of 14N atoms of histidine causes a quadrupolar relaxation enhancement (also called Quadrupolar Peak, QP) at 1.39 MHz. This QP falls at a frequency well distinc...
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#1Carla Carrera (National Research Council)H-Index: 14
#2Eleonora Cavallari (UNITO: University of Turin)H-Index: 9
Last. Francesca Reineri (UNITO: University of Turin)H-Index: 19
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An efficient synthesis of vinyl-[1-13C]pyruvate has been reported, from which 13C hyperpolarized (HP) ethyl-[1-13C]pyruvate has been obtained by means of ParaHydrogen Induced Polarization (PHIP). Due to the intrinsic lability of pyruvate, which leads quickly to degradation of the reaction mixture even under mild reaction conditions, the vinyl-ester has been synthesized through the intermediacy of a more stable ketal derivative. 13C and 1H hyperpolarizations of ethyl-[1-13C]pyruvate, hydrogenated...
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#1Jason R. Swedlow (Dund.: University of Dundee)H-Index: 59
#2Pasi Kankaanpää (Åbo Akademi University)H-Index: 20
Last. Silvio Aime (UNITO: University of Turin)H-Index: 91
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Imaging technologies are used throughout the life and biomedical sciences to understand mechanisms in biology and diagnosis and therapy in animal and human medicine. We present criteria for globally applicable guidelines for open image data tools and resources for the rapidly developing fields of biological and biomedical imaging.
9 CitationsSource