Łukasz Popiołek
Medical University of Lublin
Proton NMRCytotoxicityNuclear chemistryCarbon-13 NMRMinimum inhibitory concentrationOrganic chemistryChemistryLipophilicityIn vitroCondensation reactionCombinatorial chemistryNalidixic acidHydrazideSchiff baseMoietyCarboxylic acidAntifungal1,2,4-TriazoleAntibacterial activityBroth microdilutionAntimicrobialBacteriaStereochemistry
49Publications
11H-index
534Citations
Publications 49
Newest
#1Łukasz PopiołekH-Index: 11
Last. Monika WujecH-Index: 15
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This research describes the synthesis and in vitro antimicrobial activity study of a series of 2,4,6-trimethylbenzenesulfonyl hydrazones. Twenty-five hydrazones (2–26) were synthesized on the basis of condensation reaction. The in vitro bioactivity study confirmed the potential application of obtained derivatives as antimicrobial agents. Among the tested compounds, the highest activity was discovered for derivative 24, which possessed minimal inhibitory concentration (MIC) ranging from 7.81 to 1...
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#1Kinga ParuchH-Index: 3
#2Łukasz PopiołekH-Index: 11
Last. Monika WujecH-Index: 15
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#1Kinga ParuchH-Index: 3
#2Łukasz PopiołekH-Index: 11
Last. Monika WujecH-Index: 15
view all 6 authors...
The aim of our study was the two-stage synthesis of 1,3,4-oxadiazole derivatives. The first step was the synthesis of hydrazide–hydrazones from 3-methyl-4-nitrobenzhydrazide and the corresponding substituted aromatic aldehydes. Then, the synthesized hydrazide–hydrazones were cyclized with acetic anhydride to obtain new 3-acetyl-2,3-disubstituted-1,3,4-oxadiazolines. All of obtained compounds were tested in in vitro assays to establish their potential antimicrobial activity and cytotoxicity. Our ...
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#1Łukasz Popiołek (Medical University of Lublin)H-Index: 11
#2Paweł Patrejko (Medical University of Lublin)H-Index: 2
Last. Monika Wujec (Medical University of Lublin)H-Index: 15
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Abstract In this study 14 novel hydrazide-hydrazones of 5-bromo-2-iodobenzoic acid (3-16) were synthesized on the basis of condensation reaction. The chemical structure of obtained derivatives was established on the basis of spectral data (1H NMR and 13C NMR) and the lipophilicity of synthesized molecules was determined with the use of RP-HPTLC chromatography. Synthesized hydrazide-hydrazones (3-16) were subjected to in vitro cytotoxicity assay and antimicrobial activity analysis against a panel...
1 CitationsSource
#1Łukasz Popiołek (Medical University of Lublin)H-Index: 11
#2Monika Gawrońska‑Grzywacz (Medical University of Lublin)H-Index: 2
Last. Monika Wujec (Medical University of Lublin)H-Index: 15
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Cancer treatment remains a serious challenge worldwide. Thus, finding novel antitumour agents is of great importance. In the present study, nine new benzenesulphonohydrazide derivatives (1-9) were synthesized, and the chemical structures of the obtained compounds were confirmed by spectral analysis methods, including IR, 1H nuclear magnetic resonance (NMR) and 13C NMR. Experimental lipophilicity values were established using reversed phase-high performance thin layer chromatography. The antiprol...
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#1Łukasz Popiołek (Medical University of Lublin)H-Index: 11
#2Bernadetta Rysz (Medical University of Lublin)H-Index: 1
Last. Monika Wujec (Medical University of Lublin)H-Index: 15
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In this research, we synthesized and evaluated for in vitro antimicrobial activity a new series of hydrazide-hydrazones obtained from 5-nitrofuran-2-carboxylic acid. New compounds were identified and characterized by spectral methods ((1) H NMR and (13) C NMR). All tested hydrazide-hydrazones proved to be promising antimicrobial agents. Antimicrobial activity and antifungal activity of new derivatives of 5-nitrofuran-2-carboxylic acid were revealed in many cases to be higher than the activity of...
4 CitationsSource
#1Kinga Paruch (Medical University of Lublin)H-Index: 3
#2Łukasz Popiołek (Medical University of Lublin)H-Index: 11
Last. Monika Wujec (Medical University of Lublin)H-Index: 15
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In the last 20 years there has been a significant increase in interest in the structure of oxadiazole derivatives, especially 3-acetyl-1,3,4-oxadiazolines. It is known that these derivatives possess: antibacterial, antifungal, antitubercular, antiprotozoal, anticancer and anti-inflammatory activity. Therefore, many medicinal chemists choose 3-acetyl-1,3,4-oxadiazoline scaffold for the synthesis of new potentially active substances with a better effectiveness and less toxicity. This article is a ...
5 CitationsSource
#1Agata Paneth (Medical University of Lublin)H-Index: 13
#2Nazar Trotsko (Medical University of Lublin)H-Index: 7
Last. Monika Wujec (Medical University of Lublin)H-Index: 15
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: The series of novel Mannich bases were synthesized and evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. The results showed that all compounds were less active than the drugs used as reference, but some of them had moderate potency against Staphylococcus epidermidis ATCC 12228 and Bacillus subtilis ATCC 6633. The presence of a phenyl ring in the position 4 of piperazine seems to be necessary for antibacterial activity in this class o...
2 CitationsSource
#1Łukasz Popiołek (Medical University of Lublin)H-Index: 11
#2Anna Biernasiuk (Medical University of Lublin)H-Index: 12
Last. Monika Wujec (Medical University of Lublin)H-Index: 15
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: Thirteen new 3-acetyl-2,5-disubstituted-1,3,4-oxadiazoline derivatives were synthesized from corresponding hydrazide-hydrazones of isonicotinic acid in the reaction with acetic anhydride. The obtained compounds were identified with the use of spectral methods (IR, 1 H-NMR, 13 C-NMR, MS). In vitro antimicrobial activity screening of synthesized compounds against a panel of bacteria and fungi revealed interesting antibacterial and antifungal activity of tested 1,3,4-oxadiazoline derivatives, whi...
3 CitationsSource
#1Anna Boguszewska-Czubara (Medical University of Lublin)H-Index: 15
#2Karolina KulaH-Index: 7
Last. Radomir JasińskiH-Index: 19
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Abstract The process of searching for new antibacterial agents is more and more challenging due to the increasing drug resistance which has become a major concern in the field of infection management. Our study presents a synthesis and characterization by IR, UV, 1H NMR and 13C NMR spectra of a homogenous series of 1-EWG functionalized 2-aryl-1-nitroethenes which could prove good candidates for the replacement of traditional antibacterial drugs In vitro screening against a panel of the reference...
1 CitationsSource