Gretchen L. Gierach
University of Pittsburgh
EpidemiologyCancerInternal medicineEndocrinologyOncologyOdds ratioProspective cohort studyHazard ratioBreast diseaseBody mass indexPopulationBreast Cancer Risk FactorGynecologyPhysiologyConfidence intervalRisk factorBreast cancerMedicineRelative riskEstrogen receptor
Publications 95
#1Britton Trabert (HCI: Huntsman Cancer Institute)
#2Ashley M. GeczikH-Index: 3
Last. Andrea Z. LaCroix (UCSD: University of California, San Diego)H-Index: 40
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Background: null Postmenopausal pregnenolone and/or progesterone levels in relation to endometrial and ovarian cancer risks have been infrequently evaluated. To address this, we utilized a sensitive and reliable assay to quantify prediagnostic levels of seven markers related to endogenous hormone metabolism. null Methods: null Hormones were quantified in baseline serum collected from postmenopausal women in a cohort study nested within the Breast and Bone Follow-up to the Fracture Intervention T...
#1Qian Xiao (University of Texas Health Science Center at Houston)H-Index: 23
#2Gretchen L. GierachH-Index: 24
Last. Rena R. Jones (NIH: National Institutes of Health)H-Index: 19
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#1You Wu (Harvard University)H-Index: 2
#2Ruyi Huang (ISU: I-Shou University)
Last. Stephanie A. Smith-Warner (Harvard University)H-Index: 60
view all 40 authors...
BACKGROUND Epidemiologic studies examining the relations between dairy product and calcium intakes and breast cancer have been inconclusive, especially for tumor subtypes. OBJECTIVE To evaluate the associations between intakes of specific dairy products and calcium and risk of breast cancer overall and for subtypes defined by estrogen receptor (ER) status. METHOD We pooled the individual-level data of over 1 million women who were followed for a maximum of 8-20 years across studies. Associations...
#1Susan J. Jordan (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 30
#2Renhua Na (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 5
Last. Penelope M. Webb (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 79
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A full-term pregnancy is associated with reduced endometrial cancer risk; however, whether the effect of additional pregnancies is independent of age at last pregnancy is unknown. The associations between other pregnancy-related factors and endometrial cancer risk are less clear. We pooled individual participant data from 11 cohort and 19 case-control studies participating in the Epidemiology of Endometrial Cancer Consortium (E2C2) including 16 986 women with endometrial cancer and 39 538 contro...
2 CitationsSource
#1Heather Spencer Feigelson (KP: Kaiser Permanente)H-Index: 56
#2Clara BodelonH-Index: 14
Last. Gretchen L. GierachH-Index: 24
view all 9 authors...
BACKGROUND Breast cancer survivors are at increased risk for developing second primary cancers compared to the general population. Little is known about whether body mass index (BMI) increases this risk. We examined the association between BMI and second cancers among women with incident invasive breast cancer. METHODS This retrospective cohort included 6,481 patients from Kaiser Permanente Colorado and Washington of whom 822 (12.7%) developed a second cancer (mean follow-up was 88.0 months). BM...
2 CitationsSource
#1Mustapha AbubakarH-Index: 8
#2Shaoqi FanH-Index: 3
Last. Gretchen L. GierachH-Index: 24
view all 14 authors...
Background Benign breast disease (BBD) is a strong breast cancer risk factor, but identifying patients that might develop invasive breast cancer remains a challenge. Methods By applying machine-learning to digitized hematoxylin and eosin-stained biopsies and computer-assisted thresholding to mammograms obtained circa BBD diagnosis, we generated quantitative tissue composition metrics and determined their association with future invasive breast cancer diagnosis. Archival breast biopsies and mammo...
#1Sarah S. JacksonH-Index: 11
#2Hans-Olov Adami (KI: Karolinska Institutet)H-Index: 168
Last. Jill KoshiolH-Index: 31
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Abstract Background Gallbladder cancer (GBC) has a female predominance, although other biliary tract cancers (BTCs) such as extrahepatic and intrahepatic bile duct (EHBDC and IHBDC) and ampulla of Vater (AVC) have a male predominance. The role of female reproductive factors in BTC etiology remains unclear. Methods We pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive yea...
2 CitationsSource
#1Nicole M. Niehoff (NIH: National Institutes of Health)H-Index: 8
#2Alexander P. Keil (UNC: University of North Carolina at Chapel Hill)H-Index: 13
Last. Alexandra J. White (NIH: National Institutes of Health)H-Index: 18
view all 6 authors...
Exposure to certain outdoor air pollutants may be associated with a higher risk of breast cancer, though potential underlying mechanisms are poorly understood. We examined whether outdoor air pollution was associated with involution of terminal duct lobular units (TDLUs), the histologic site where most cancers arise and an intermediate marker of breast cancer risk. Pathologist-enumerated TDLUs were assessed in HE 95% CI: 1.01–1.11). This association was evident among both premenopausal and postm...
1 CitationsSource
#1Shaoqi FanH-Index: 3
#2Ruth M. PfeifferH-Index: 89
Last. Gretchen L. GierachH-Index: 24
view all 17 authors...
#1Mengmeng Jia (Peking Union Medical College)
Last. Gretchen L. GierachH-Index: 24
view all 7 authors...
Periodontal disease may be associated with increased breast cancer risk, but studies have not considered invasive breast cancer and ductal carcinoma in situ (DCIS) separately in the same population. We assessed the relationship between periodontal disease and breast cancer in a large prospective cohort study. The Sister Study followed women without prior breast cancer aged 35-74 years from 2003-2017 (N=49,968). Baseline periodontal disease was self-reported, and incident breast cancer was ascert...
1 CitationsSource