Petra Seibold
University Hospitals of Leicester NHS Trust
Genome-wide association studyCancerInternal medicineGenotypeOncologyCase-control studySingle-nucleotide polymorphismOdds ratioAlleleProspective cohort studyCohort studyHazard ratioPopulationGynecologyProportional hazards modelRadiation therapyBreast cancerGeneticsMedicineCohortBiology
Publications 97
#1Nicola Rares Franco (Ghent University Hospital)
#1Nicola Rares Franco (Ghent University Hospital)H-Index: 1
Last. Tiziana RancatiH-Index: 27
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AIM To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi). MATERIALS AND METHODS Analysis included the REQUITE PCa cohort that received external beam RT and was followed for 2 years. Late toxicity endpoints were: rectal bleeding, urinary frequency, haematuria, nocturia, decreased urinary stream. Among 43 li...
#1Tim Rattay (University of Leicester)H-Index: 9
#2Petra Seibold (DKFZ: German Cancer Research Center)H-Index: 27
Last. Sheryl GreenH-Index: 18
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Background: Acute skin toxicity is a common and usually transient side-effect of breast radiotherapy although, if sufficiently severe, it can affect breast cosmesis, aftercare costs and the patient's quality-of-life. The aim of this study was to develop predictive models for acute skin toxicity using published risk factors and externally validate the models in patients recruited into the prospective multi-center REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to red...
1 CitationsSource
#1Michela Carlotta Massi (Polytechnic University of Milan)H-Index: 2
#2Francesca Gasperoni (Medical Research Council)
Last. Tiziana RancatiH-Index: 27
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Background: REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to reduce side effects and improve QUalITy of lifE in cancer survivors) is an international prospective cohort study. The purpose of this project was to analyse a cohort of patients recruited into REQUITE using a deep learning algorithm to identify patient-specific features associated with the development of toxicity, and test the approach by attempting to validate previously published genetic risk factors....
2 CitationsSource
#1Sonja Neumeyer (DKFZ: German Cancer Research Center)H-Index: 2
#2Xinwei Hua (Fred Hutchinson Cancer Research Center)H-Index: 6
Last. Jenny Chang-Claude (DKFZ: German Cancer Research Center)H-Index: 124
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Background: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better colorectal cancer survival. Tregs, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and therefore variants in genes related to Treg differentiation and function could be associated with colorectal cancer prognosis. Methods: In a prospective German cohort of 3,593 colorectal cancer patients, we assessed the association of 771 single-nucleotide...
#1Dominique Scherer (DKFZ: German Cancer Research Center)H-Index: 9
#2Heike Deutelmoser (DKFZ: German Cancer Research Center)H-Index: 2
Last. Cornelia M. Ulrich (DKFZ: German Cancer Research Center)H-Index: 90
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An individual’s inherited genetic variation may contribute to the ‘angiogenic switch’, which is essential for blood supply and tumor growth of microscopic and macroscopic tumors. Polymorphisms in angiogenesis-related genes potentially predispose to colorectal cancer (CRC) or affect the survival of CRC patients. We investigated the association of 392 single nucleotide polymorphisms (SNPs) in 33 angiogenesis-related genes with CRC risk and survival of CRC patients in 1754 CRC cases and 1781 health...
2 CitationsSource
#1Petra Seibold (DKFZ: German Cancer Research Center)H-Index: 27
#2Anssi Auvinen (Radiation and Nuclear Safety Authority)H-Index: 101
Last. Maria Blettner (University of Mainz)H-Index: 69
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Purpose: To summarize existing knowledge and to understand individual response to radiation exposure, the MELODI Association together with CONCERT European Joint Programme has organized a w...
15 CitationsSource
#1Charlie Zhong (Beckman Research Institute)H-Index: 3
#1Charlie Zhong (Beckman Research Institute)H-Index: 1
Last. Sophia S. Wang (Beckman Research Institute)H-Index: 71
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Background: We assessed the ability to supplement existing epidemiological/etiologic studies with data on treatment and clinical outcomes by linking to publicly available cancer registry and administrative databases. Methods: Medical records were retrieved and abstracted for cases enrolled in a Los Angeles County case-control study of non-Hodgkin Lymphoma(NHL). Cases were linked to the Los Angeles County cancer registry(CSP), the California state hospitalization discharge database(OSHPD), and th...
1 CitationsSource