Sayoki Mfinanga
National Institute for Medical Research
EpidemiologyDrug resistanceInternal medicinePublic healthCross-sectional studyVirologyHealth careIntensive care medicinePediatricsImmunologySputumMycobacterium tuberculosisTanzaniaTuberculosisAcquired immunodeficiency syndrome (AIDS)PopulationHuman immunodeficiency virus (HIV)Family medicineMedicineEnvironmental health
Publications 121
#1Elizabeth H. ShayoH-Index: 16
#2Sokoine KivuyoH-Index: 9
Last. Marie Claire Van HoutH-Index: 20
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#1David B. Meya (UMN: University of Minnesota)H-Index: 34
#2Lillian Tugume (MUK: Makerere University)H-Index: 10
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The World Health Organization (WHO) has published a guideline for the management of individuals with advanced HIV disease (AHD) to reduce HIV-related deaths. The guideline consists of a package of recommendations including interventions to prevent, diagnose and treat common opportunistic infections, including tuberculosis (TB), cryptococcosis and severe bacterial infections, along with rapid initiation of antiretroviral treatment and enhanced adherence support. Currently no clear targets exist f...
#1Newton Kalata (Malawi-Liverpool-Wellcome Trust Clinical Research Programme)H-Index: 3
#2Jayne Ellis (UCL: University College London)H-Index: 6
Last. Tinashe K. Nyazika (Malawi-Liverpool-Wellcome Trust Clinical Research Programme)H-Index: 7
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Background An increasing proportion of patients with HIV-associated cryptococcal meningitis have received antiretroviral therapy (ART) prior to presentation. There is some evidence suggesting an increased two-week mortality in those receiving ART for less than 14 days compared with those on ART for more than 14 days. However, presentation and outcomes for cryptococcal meningitis patients who have recently initiated ART, and those with virologic failure and/or non-adherence are not well described...
#1Olukemi Adeyemi (LSTM: Liverpool School of Tropical Medicine)
#2Mary Lyons (LSTM: Liverpool School of Tropical Medicine)
Last. Anupam Garrib (LSTM: Liverpool School of Tropical Medicine)H-Index: 4
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Background Low-income and middle-income countries are struggling to manage growing numbers of patients with chronic non-communicable diseases (NCDs), while services for patients with HIV infection are well established. There have been calls for integration of HIV and NCD services to increase efficiency and improve coverage of NCD care, although evidence of effectiveness remains unclear. In this review, we assess the extent to which National HIV and NCD policies in East Africa reflect the calls f...
#1Martin HoeniglH-Index: 42
#2Jon Salmanton-García (University of Cologne)H-Index: 7
Last. Oliver A. CornelyH-Index: 91
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Summary With increasing numbers of patients needing intensive care or who are immunosuppressed, infections caused by moulds other than Aspergillus spp or Mucorales are increasing. Although antifungal prophylaxis has shown effectiveness in preventing many invasive fungal infections, selective pressure has caused an increase of breakthrough infections caused by Fusarium, Lomentospora, and Scedosporium species, as well as by dematiaceous moulds, Rasamsonia, Schizophyllum, Scopulariopsis, Paecilomyc...
13 CitationsSource
#1Peter M. Mbelele (AIST: National Institute of Advanced Industrial Science and Technology)H-Index: 3
#1Peter M. Mbelele (AIST: National Institute of Advanced Industrial Science and Technology)
Last. Stellah G. Mpagama (AIST: National Institute of Advanced Industrial Science and Technology)
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Background: Rifampicin or multidrug-resistant-tuberculosis (RR/MDR-TB) treatment has largely transitioned to regimens free of the injectable aminoglycoside component despite the drug class' purported bactericidal activity early in treatment. We tested whether Mycobacterium tuberculosis (Mtb) killing rates measured by molecular bacterial load assay (TB-MBLA) in sputa correlate with composition of the RR/MDR-TB regimen.Methods: Serial sputa were collected from patients with RR/MDR- and drug-sensit...
2 CitationsSource
#1Ahmed Gharib Khamis (MUHAS: Muhimbili University of Health and Allied Sciences)H-Index: 1
#2Mbazi Senkoro (NIMR: National Institute for Medical Research)H-Index: 5
Last. Gideon Kwesigabo (MUHAS: Muhimbili University of Health and Allied Sciences)H-Index: 23
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Background Hypertension is among the growing non-communicable diseases (NCDs) in developing countries and the leading cause of death worldwide. Pastoral areas have been identified to be at a higher risk of diseases due to challenges in their daily food production, livelihoods or mobility. Unfortunately, the prevalence of hypertension and the risk factors particularly affecting rural and pastoral populations are not fully understood, making intervention efforts challenging. The aim of this study ...
2 CitationsSource
#1Marie Claire Van Hout (LJMU: Liverpool John Moores University)H-Index: 20
#2Max O Bachmann (UEA: University of East Anglia)H-Index: 39
Last. Shabbar Jaffar (LSTM: Liverpool School of Tropical Medicine)H-Index: 70
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Introduction In sub-Saharan Africa, the burden of non-communicable diseases (NCDs), particularly diabetes mellitus (DM) and hypertension, has increased rapidly in recent years, although HIV infection remains a leading cause of death among young-middle-aged adults. Health service coverage for NCDs remains very low in contrast to HIV, despite the increasing prevalence of comorbidity of NCDs with HIV. There is an urgent need to expand healthcare capacity to provide integrated services to address th...
#1Peter M. MbeleleH-Index: 3
#2Emmanuel A. MpolyaH-Index: 8
Last. Stellah G. MpagamaH-Index: 13
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Background: Rifampin or multidrug-resistant-tuberculosis (RR/MDR-TB) treatment has transitioned to injectable-free regimens. We tested whether M. tuberculosis (Mtb) elimination rates measured by molecular bacterial load assay (TB-MBLA) in sputa correlate with the composition of the RR/MDR-TB antibiotic regimen. Methods: Serial sputa were collected from patients with RR/MDR- and drug-sensitive TB at day 0, 3, 7, 14, and then monthly for 4 months of anti-TB treatment. TB-MBLA was used to quantify ...