Gabriel J. Starrett
Harvard University
GeneCancerDownregulation and upregulationDeep sequencingGenomeMetagenomicsVirologyVirusCytosineAPOBECMerkel cell polyomavirusCytosine deaminaseMutationCancer researchBreast cancerGeneticsDNACarcinogenesisComputational biologyMedicineBiologyCell biology
58Publications
21H-index
1,958Citations
Publications 48
Newest
3 CitationsSource
#1Michael R. SargenH-Index: 8
#2Gabriel J. Starrett (NIH: National Institutes of Health)H-Index: 21
Last. Alisa M. GoldsteinH-Index: 3
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Sebaceous carcinoma is an aggressive skin cancer with a 5-year overall survival rate of 78% for localized/regional disease and 50% for metastatic disease. The incidence of this cancer has been increasing in the United States for several decades, but the underlying reasons for this increase are unclear. In this article, we review the epidemiology and genetics of sebaceous carcinoma, including recent population data and tumor genomic analyses that provide new insights into underlying tumor biology...
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#1Emily K. LawH-Index: 13
#2Rena Levin-Klein (UMN: University of Minnesota)H-Index: 6
Last. Reuben S. HarrisH-Index: 78
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The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second largest source of mutation in cancer. This mutational process may be a causal driver or inconsequential passenger to the overall tumor phenotype. We show that human APOBEC3A expression in murine colon and liver tissues increases tumorigenesis. All other APOBEC3 family members, including APOBEC3B, fail to promote liver tumor formation. Tumor DNA sequences from APOBEC3A-expressing animals display hallmark APOBEC si...
18 CitationsSource
#1Alec Kacew (U of C: University of Chicago)H-Index: 6
#2Harita Dharaneeswaran (Harvard University)H-Index: 2
Last. Glenn J. Hanna (Harvard University)H-Index: 17
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Background Merkel cell carcinoma is a rare cancer for which the standard-of-care is immune checkpoint blockade in the recurrent/metastatic setting. However, immunotherapy is not effective in all patients. A greater understanding of molecular mechanisms and potential predictive biomarkers are unmet needs for clinicians and researchers. Methods We undertook a retrospective analysis of 45 patients treated at our institution from 2013 to 2020 to understand the clinical and genomic correlates of clin...
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#1Gabriel J. StarrettH-Index: 21
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
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4 CitationsSource
#1Gabriel J. StarrettH-Index: 21
#2Kelly J. YuH-Index: 18
Last. Christopher B. BuckH-Index: 52
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BK polyomavirus (BKPyV) is a ubiquitous virus that establishes a lifelong subclinical infection in the urinary tract. In transplant recipients, BKPyV can reactivate and cause kidney and bladder damage. Recent sequencing studies of tumors from transplant recipients have revealed that BKPyV sequences are present in approximately 25% of bladder tumors. This is dramatically higher than the Citation Format: Gabriel J. Starrett, Kelly Yu, David Petersen, Petra Lenz, Lars Dyrskjot, Paul Meltzer, Eric E...
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#1Michael K. Slevin (Harvard University)H-Index: 9
#2Bruce M. Wollison (Harvard University)H-Index: 8
Last. Laura E. MacConaill (Harvard University)H-Index: 54
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Abstract Precision cancer medicine aims to classify tumors by site, histology, and molecular testing to determine an “individualized” profile of cancer alterations. Viruses are a major contributor to oncogenesis, causing 12-20% of all human cancers. A number of viruses are causal of specific types of cancer, promoting dysregulation of signaling pathways resulting in carcinogenesis. In addition, integration of viral DNA into the host (human) genome is a hallmark of some viral species. Tests for t...
5 CitationsSource
#1Gabriel J. StarrettH-Index: 21
#2Manisha Thakuria (Dana Corporation)H-Index: 1
Last. James A. DeCaprio (Harvard University)H-Index: 79
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BACKGROUND: Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin caused by either the integration of Merkel cell polyomavirus (MCPyV) and expression of viral T antigens or by ultraviolet-induced damage to the tumor genome from excessive sunlight exposure. An increasing number of deep sequencing studies of MCC have identified significant differences between the number and types of point mutations, copy number alterations, and structural variants between virus-po...
35 CitationsSource
#1Nicole L. WelchH-Index: 5
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
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Abstract Adenoviruses, papillomaviruses, and polyomaviruses are collectively known as small DNA tumor viruses. Although it has long been recognized that small DNA tumor virus oncoproteins and capsid proteins show a variety of structural and functional similarities, it is unclear whether these similarities reflect descent from a common ancestor, convergent evolution, horizontal gene transfer among virus lineages, or acquisition of genes from host cells. Here, we report the discovery of a dozen ne...
6 CitationsSource
#1Gabriel J. StarrettH-Index: 21
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
view all 7 authors...
Abstract Polintons (also known as Mavericks) were initially identified as a widespread class of eukaryotic transposons named for their hallmark type B DNA polymerase and retrovirus-like integrase genes. It has since been recognized that many polintons encode possible capsid proteins and viral genome-packaging ATPases similar to those of a diverse range of double-stranded DNA (dsDNA) viruses. This supports the inference that at least some polintons are viruses that remain capable of cell-to-cell ...
4 CitationsSource