Mustafa Anjari
Hammersmith Hospital
AnatomyInternal medicineDiffusion (business)PathologyMagnetic resonance imagingHyperintensityDiffusion MRIPsychologyCardiologyImage registrationPediatricsGenu of the corpus callosumInternal capsuleCorpus callosumGestational ageCentrum semiovaleNeuroradiologyExternal capsuleWhite matterPostmenstrual AgeMathematicsNuclear magnetic resonanceVoxelEffective diffusion coefficientMedicineTractographyFractional anisotropy
11Publications
7H-index
907Citations
Publications 11
Newest
#1Arian Lasocki (Peter MacCallum Cancer Centre)H-Index: 11
#2Mustafa AnjariH-Index: 7
Last. Stefanie Thust (UCL Institute of Neurology)H-Index: 7
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Molecular parameters have become integral to glioma diagnosis. Much of radiogenomics research has focused on the use of advanced MRI techniques, but conventional MRI sequences remain the mainstay of clinical assessments. The aim of this research was to synthesize the current published data on the accuracy of standard clinical MRI for diffuse glioma genotyping, specifically targeting IDH and 1p19q status. A systematic search was performed in September 2019 using PubMed and the Cochrane Library, i...
3 CitationsSource
#1Gareth Ball (Hammersmith Hospital)H-Index: 26
#2Serena J. Counsell (Hammersmith Hospital)H-Index: 79
Last. James P. Boardman (Hammersmith Hospital)H-Index: 36
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Abstract Preterm birth is associated with altered white matter microstructure, defined by metrics derived from diffusion tensor imaging (DTI). Tract-based spatial statistics (TBSS) is a useful tool for investigating developing white matter using DTI, but standard TBSS protocols have limitations for neonatal studies. We describe an optimised TBSS protocol for neonatal DTI data, in which registration errors are reduced. As chronic lung disease (CLD) is an independent risk factor for abnormal white...
142 CitationsSource
#1Mary A. Rutherford (Hammersmith Hospital)H-Index: 92
#2Veena Supramaniam (Hammersmith Hospital)H-Index: 13
Last. Luca A. Ramenghi (University of Milan)H-Index: 22
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Periventricular leucomalacia (PVL) and parenchymal venous infarction complicating germinal matrix/intraventricular haemorrhage have long been recognised as the two significant white matter diseases responsible for the majority of cases of cerebral palsy in survivors of preterm birth. However, more recent studies using magnetic resonance imaging to assess the preterm brain have documented two new appearances, adding to the spectrum of white matter disease of prematurity: punctate white matter les...
114 CitationsSource
#1Shuzhou Jiang (Hammersmith Hospital)H-Index: 8
#2Hui Xue (Hammersmith Hospital)H-Index: 29
Last. Joseph V. Hajnal (Imperial College London)H-Index: 85
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We present a methodology to achieve 3D high-resolution diffusion tensor image reconstruction of the brain in moving subjects. The source data is diffusion-sensitized single-shot echo-planar images. After continuous scanning to acquire a repeated series of parallel slices with 15 diffusion directions, image registration is used to realign the images to correct for subject motion. Once aligned, the diffusion images are treated as irregularly-sampled data where each voxel is associated with an appr...
80 CitationsSource
#1Mustafa Anjari (Imperial College London)H-Index: 7
#2Serena J. CounsellH-Index: 79
Last. A. David EdwardsH-Index: 72
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OBJECTIVE: Preterm infants have a high incidence of neurodevelopmental impairment associated with diffuse cerebral white matter abnormalities and also a high incidence of serious respiratory disease. However, it is unclear if lung disease and brain injury are related, and previous research has been impeded by confounding effects, including prematurity and infection. Using a new approach that permits multivariate statistical analysis, we tested the hypothesis that lung disease is associated with ...
69 CitationsSource
#1Serena J. Counsell (Imperial College London)H-Index: 79
#2A. David Edwards (Imperial College London)H-Index: 72
Last. Frances M. Cowan (Imperial College London)H-Index: 59
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structure. We studied 33 children, born at a median (range) gestational age of 28 +5 (24 +4 ^32 +1 )w eeks. The children were recruited as infants from the Neonatal Intensive Care Unit at Queen Charlotte’s and Hammersmith Hospital in the early neonatal period and imaged at a median corrected age of 25.5 (24^27) months.The children underwent diffusion tensor imaging to measure fractional anisotropy (FA) as a measure of tissue microstructure, and neurodevelopmental assessment using the Griffiths M...
240 CitationsSource
#1Jeroen Dudink (Imperial College London)H-Index: 25
#2Mustafa Anjari (Imperial College London)H-Index: 7
Last. Serena J. Counsell (Imperial College London)H-Index: 79
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Background Major focal white matter lesions in the preterm brain such as periventricular haemorrhagic infarctions (PVHI) are often associated with significant cognitive and motor deficits, which may be due to disrupted connections between central and cortical grey matter. Probabilistic diffusion tractography allows connectivity between the thalamus and cortex to be assessed in vivo. Objective To examine thalamocortical connectivity in preterm infants with unilateral PVHI in the early preterm per...
#1Shuzhou Jiang (Imperial College London)H-Index: 8
#2Hui Xue (Imperial College London)H-Index: 29
Last. Joseph V. Hajnal (Imperial College London)H-Index: 85
view all 8 authors...
We present a methodology to achieve 3D high resolution in-utero fetal brain DTI that shows excellent ADC as well as promising FA maps. After continuous DTI scanning to acquire a repeated series of parallel slices with 15 diffusion directions, image registration is used to realign the images to correct for fetal motion. Once aligned, the diffusion images are treated as irregularly sampled data where each voxel is associated with an appropriately rotated diffusion direction, and used to estimate t...
18 CitationsSource
#1Mustafa Anjari (Imperial College London)H-Index: 7
#2Latha Srinivasan (Imperial College London)H-Index: 16
Last. Serena J. Counsell (Imperial College London)H-Index: 79
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Abstract Infants born preterm have a high incidence of neurodevelopmental impairment in later childhood, often associated with poorly defined cerebral white matter abnormalities. Diffusion tensor imaging quantifies the diffusion of water within tissues and can assess microstructural abnormalities in the developing preterm brain. Tract-based spatial statistics (TBSS) is an automated observer-independent method of aligning fractional anisotropy (FA) images from multiple subjects to allow groupwise...
270 CitationsSource
#1Mustafa AnjariH-Index: 7
#2L. SrinivasanH-Index: 1
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(25.7-28.0) weeks, and the median (range) post-menstrual age at imaging was 41.0 (38.1-44.0) weeks. MRI was performed on a Philips 3 Tesla system using a phased array head coil. 3D MPRAGE and T2 weighted FSE images were obtained prior to DTI. Single shot echo planar DTI was acquired in 15 non-collinear directions using the following parameters; TR = 8000ms, TE = 79ms, slice thickness = 2mm, voxel size = 1.75 x 1.75 x 2 mm 3 , NSA = 2, b value = 750 s/mm 2 , SENSE factor = 2. Distortions due to e...