Yuki Kakio
Okayama University
Internal medicineEndocrinologyLogistic regressionOdds ratioRenal functionCardiologyChemistryInflammationSalineHemodialysisKidney diseaseDiseaseAbdominal aortic aneurysmAngiotensin IIVasohibin 2Chronic hemodialysisIn patientDeficient mouseConfidence intervalDiabetes mellitusApolipoprotein EMedicineBlood pressureGastroenterology
29Publications
6H-index
111Citations
Publications 28
Newest
#1Nozomu Otaka (Okayama University)H-Index: 4
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun Wada (Okayama University)H-Index: 1
view all 13 authors...
BACKGROUND Vasohibin-2 (VASH2) has been isolated as a homologue of vasohibin-1 (VASH1) that promotes angiogenesis counteracting with VASH1. Chronic angiotensin II (AngII) infusion promotes both ascending and abdominal aortic aneurysms (AAs) in mice. The present study aimed to investigate whether exogenous VASH2 influenced AngII-induced vascular pathology in apolipoprotein E-deficient (ApoE-/-) mice. METHODS Male, ApoE-/- mice (9-14 weeks old) were injected with Ad LacZ or Ad VASH2. After a week,...
1 CitationsSource
#1Yoshiko Hada (Okayama University)H-Index: 2
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun Wada (Okayama University)H-Index: 1
view all 10 authors...
The aim of the present study was to examine whether inhibition of Interleukin (IL)-6 signaling by MR16-1, an IL-6 receptor antibody, attenuates aortitis, cardiac hypertrophy, and arthritis in IL-1 receptor antagonist deficient (IL-1RA KO) mice. Four weeks old mice were intraperitoneally administered with either MR16-1 or non-immune IgG at dosages that were adjusted over time for 5 weeks. These mice were stratified into four groups: MR16-1 treatment groups, KO/MR low group (first 2.0 mg, followin...
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#1Yasuhiro Onishi (Okayama University)H-Index: 2
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Kenichiro AsanoH-Index: 4
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AIM: Deteriorated health-related quality of life (HRQOL) is associated with increased risk for death in both chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients; however, the impact of HRQOL on CKD progression is not well investigated. METHODS: We aimed to evaluate the association between HRQOL and CKD progression in Japanese patients with CKD. One hundred and three outpatients who visited the department of nephrology at our hospital (mean estimated glomerular filtration rat...
1 CitationsSource
Background: From 2011, Okayama municipal government started the health checkup follow-up project to find those who were unaware of suffering chronic kidney disease and to prevent from aggravation of CKD stage. In this study, we aimed to evaluate the effect of 2 years' CKD-follow-up project regarding renal function and CKD risks. Patients and methods: Those who received a health checkup by the national health insurance in Okayama city in 2011 were recruited. The patients with lifestyle-related di...
1 CitationsSource
Objective: Chronic angiotensin II (AngII) infusion promotes both ascending (TAAs) and abdominal aortic aneurysms (AAAs) in mice. Previously, we demonstrated that exogenous vasohibin-2 (VASH-2) exac...
#1Ryoko Umebayashi (Okayama University)H-Index: 7
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun Wada (Okayama University)H-Index: 63
view all 7 authors...
AbstractPurpose: The purpose of present study was to evaluate the clinical efficacy of irbesartan on the anti-inflammatory and anti-oxidative stress effect in patients with hypertension compared to...
2 CitationsSource
#1Michihiro Okuyama (UK: University of Kentucky)H-Index: 6
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun Wada (Okayama University)H-Index: 63
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Background: Chronic angiotensin II (AngII) infusion promotes ascending aortic dilation in C57BL/6J mice. Meanwhile, vasohibin-2 (VASH2) is an angiogenesis promoter in neovascularization under various pathologic conditions. The aim of this study was to investigate whether exogenous VASH2 influences chronic AngII-induced ascending aortic dilation. Methods and Results: Eight-ten-week-old male C57BL/6J mice were injected with adenovirus (Ad) expressing either VASH2 or LacZ. One week after the inject...
2 CitationsSource
#1Yuka Okuyama (Okayama University)H-Index: 5
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun Wada (Okayama University)H-Index: 63
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This study aimed to clarify the relationship between repeated measurements of casual (spot) and 24-h urinary sodium-to-potassium (Na/K) ratios in patients with chronic kidney disease (CKD). A total of 61 inpatients with CKD, 31 in stage 1–3 (eGFR [estimated glomerular filtration rate] ≥ 30 ml/min/1.73 m2) and 30 in stage 4–5 (eGFR < 30 ml/min/1.73 m2), aged 20–85 consuming a low-sodium diet (NaCl [sodium chloride] 6 g/day) were recruited. Urinary Na, K, and Na/K ratios were measured in both casu...
2 CitationsSource
#1Yuki Kakio (Okayama University)H-Index: 6
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun Wada (Okayama University)H-Index: 63
view all 12 authors...
AIM: Since 1998, the leading cause of chronic hemodialysis in Japan has been diabetic nephropathy. Diabetes mellitus is known to be a risk factor for frailty, but it still remains unknown whether diabetic nephropathy is associated with frailty in chronic dialysis patients. The authors carried out the present study to reveal the association between frailty and diabetic nephropathy in chronic hemodialysis patients. METHODS: A total of 355 patients who were on hemodialysis were recruited. Participa...
10 CitationsSource